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TranscriptomicsCSR-1 and P granules suppress sperm-specific transcription in the C. elegans germline
P granules in C. elegans are required for fertility and function to maintain germ cell identity and pluripotency.  Sterility in the absence of P granules is often accompanied by the mis-expression of soma-specific proteins and the initiation of somatic differentiation in germ cells.  To investigate ...
ORGANISM(S): Caenorhabditis elegans 
2015-05-20 | E-GEOD-67954 | biostudies-arrayexpress
TranscriptomicsTracking the Fragile X Mental Retardation Protein in a Highly Ordered Neuronal RiboNucleoParticles Population: a Link Between Stalled Polyribosomes and RNA Granules
Local translation at the synapse plays key roles in neuron development and activity-dependent synaptic plasticity. mRNAs are translocated from the neuronal soma to the distant synapses as compacted ribonucleoparticles referred to as RNA granules. These contain many RNA-binding proteins, including th...
ORGANISM(S): Mus musculus 
2016-06-30 | E-GEOD-83835 | biostudies-arrayexpress
ProteomicsInitiation of B-type starch granules in wheat endosperm requires the plastidial α-glucan phosphorylase PHS1.
PHS1 is a plastidial α-glucan phosphorylase that can elongate and degrade maltooligosaccharides (MOS), but its exact physiological role in plants is poorly understood. Here, we discover a specialised role of PHS1 in establishing the unique bimodal characteristic of starch granules in the wheat endos...
ORGANISM(S): Triticum turgidum 
2024-01-22 | PXD042396 | Pride
Phs1/pho1 Bgc1 A- and b-type granules Wheat 
ProteomicsThe proteome of neuromelanin granules in dementia with Lewy bodies
Neuromelanin granules (NMGs) are organelle-like structures present in the human substantia nigra pars compacta. Besides neuromelanin, NMGs contain proteins, lipids and metals. As NMG-containing dopaminergic neurons are preferentially lost in Parkinson’s disease and dementia with Lewy bodies (DLB), i...
ORGANISM(S): Homo sapiens (Human) 
2023-02-14 | PXD035310 | Pride
Proteomics Stress granules Substantia nigra pars compacta Dementia with lewy bodies Neurodegeneration Neuromelanin granules 
ProteomicsCytosolic interaction with RNA-helicase DDX39A titrates viral RNA G-quadruplex mediated α-Synuclein amyloidogenesis
Amyloid aggregates of α-Synuclein are hallmark of Parkinson’s Disease (PD) and related neurodegenerative diseases. α-Synuclein, being an non-canonical RNA-binding protein (RBP), associates with other RBPs within cytosolic RNA-protein granules to modulate mRNA-stability. Conversely, mRNA G-quadruplex...
ORGANISM(S): Homo sapiens (Human) 
2026-09-05 | PXD075221 | Pride
Α-synuclein Rna g-quadruplex Ddx39a Viral infection Phase separation Amyloids 
ProteomicsCytosolic interaction with RNA-helicase DDX39A titrates viral RNA G-quadruplex mediated α-Synuclein amyloidogenesis
Amyloid aggregates of α-Synuclein are hallmark of Parkinson’s Disease (PD) and related neurodegenerative diseases. α-Synuclein, being an non-canonical RNA-binding protein (RBP), associates with other RBPs within cytosolic RNA-protein granules to modulate mRNA-stability. Conversely, mRNA G-quadruplex...
ORGANISM(S): Homo sapiens (Human) 
2026-09-05 | PXD075151 | Pride
Α-synuclein Rna g-quadruplex Ddx39a Viral infection Phase separation Amyloids 
ProteomicsCharacterization of the proteome of human blood platelet sercretory granules using gas-phase fractionation (GPF)
We performed an extensive qualitative characterization of the platelet granule proteome using subcellular fractionation followed by mass spectrometry analysis and functional annotation. Platelets were isolated from whole blood by centrifugation and their level of purity was tested by microscopic ins...
ORGANISM(S): Homo sapiens (Human) 
2014-03-06 | PXD000618 | Pride
Platelet Secretory granules Gpf4 
UnknownTargeting transgenic proteins to alpha granules for platelet-directed gene therapy.
Not available
S-EPMC8783114 | biostudies-literature
TranscriptomicsPaneth cell granule dissolution and bacterial colonization in the intestine of CF mice
Paneth cells of intestinal crypts contribute to host defense by producing antimicrobial peptides that are packaged as granules for secretion into the crypt lumen. Here, we provide evidence using light and electron microscopy that postsecretory Paneth cell granules undergo limited dissolution and acc...
ORGANISM(S): Mus musculus 
2010-06-09 | E-GEOD-2958 | biostudies-arrayexpress
UnknownThe α-granule proteome: novel proteins in normal and ghost granules in gray platelet syndrome.
Not available
S-EPMC2953603 | biostudies-literature
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