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MetabolomicsMetabolome analysis on multi-connected biparental chromosome segment substitution line populations in rice
Not available
ORGANISM(S): Oryza sativa Japonica Group 
ST001031 | MetabolomicsWorkbench
GenomicsDivergent residues within histone H3 define a unique chromatin structure in S. cerevisiae
Histones are among the most conserved proteins known, but organismal differences do exist. In this study we examined the contribution that divergent amino acids within histone H3 make to cell growth and chromatin structure in S. cerevisiae. We show that, while amino acids that define histone H3.3 ar...
ORGANISM(S): Saccharomyces cerevisiae 
2015-11-10 | E-GEOD-73425 | biostudies-arrayexpress
MetabolomicsGut microbiota-induced perturbations in bile acids alter keratinocyte lipid metabolism via FXR-NQO1 signaling in psoriasis
Emerging evidence has shown that microbiota dysbiosis and aberrant bile acids (BAs) profiles are correlated with disease progression. This study elucidates dysregulated BAs metabolism in psoriasis patients and imiquimod-treated female mice, coupled with increased expression of the farnesoid X recept...
2026-03-31 | MTBLS14191 | MetaboLights
TranscriptomicsTranscription Factor Substitution during the Evolution of Fungal Ribosome Regulation_ChIP-CHIP
Coordinated ribosomal protein (RP) gene expression is crucial for cellular viability, but the transcriptional network controlling this regulon has only been well characterized in the yeast Saccharomyces cerevisiae. We have used whole-genome transcriptional and location profiling to establish that, i...
ORGANISM(S): Candida albicans 
2010-05-25 | E-GEOD-10458 | biostudies-arrayexpress
TranscriptomicsTranscription Factor Substitution during the Evolution of Fungal Ribosome Regulation_expression profiling
Coordinated ribosomal protein (RP) gene expression is crucial for cellular viability, but the transcriptional network controlling this regulon has only been well characterized in the yeast Saccharomyces cerevisiae. We have used whole-genome transcriptional and location profiling to establish that, i...
ORGANISM(S): Candida albicans 
2010-05-25 | E-GEOD-10499 | biostudies-arrayexpress
ProteomicsIncorporation of photo-amino acids in HeLa cells
In order to assess the efficiency of photo-labeling, total HeLa cell lysates treated with photo-amino acids were subjected to proteome analysis.
ORGANISM(S): Homo sapiens (Human) 
2017-04-10 | PXD005346 | Pride
Hela cells Incorporation Photo-methionine Photo-leucine Orbitrap fusion 
ProteomicsIncorporation of nonproteinogenic amino acids into bacterial proteome analyzed by unbiased quantitative MS of protein modifications
To study incorporation of nonproteinogenic amino acids in bacterial proteome we performed a global, unbiased protein modification analysis of the E. coli K12 strain with defective editing mechanism of the leucyl tRNA synthetase (LeuRS), which in addition to leucine incorporates a nonproteinogenic am...
ORGANISM(S): Escherichia coli 
2016-07-11 | PXD003468 | Pride
Mistranslation Trna synthetase Norvaline Leucine Nonproteinogenic amino acids Orbitrap 
UnknownStabilization of Angiotensin-(1-7) by key substitution with a cyclic non-natural amino acid.
Not available
S-EPMC9239115 | biostudies-literature
TranscriptomicsThe bile acid CoA ligase, FATP5, is necessary for NAT synthesis in the liver
This study aimed to investigate the overlap between hepatic NAT and the bile acid synthesis to identify additional enzymes involved in NAT synthesis in the liver. We sequenced livers high-fat fed mice the were either wild-type or with a single-amino acid substitution in fatty acid amide hydrolase (F...
ORGANISM(S): Mus musculus 
2026-03-02 | E-MTAB-15752 | biostudies-arrayexpress
ProteomicsResiliance and proteome response of Escherichia coli to high levels of isoleucine mistranslation
Correct pairing of amino acids and tRNA is prerequisite for correct translation of genetic information during protein biosynthesis. Here, we present effects of proteome-wide isoleucine mistranslation in Escherichia coli induced by editing-defective isoleucyl-tRNA synthetase (IleRS). Two types of mis...
ORGANISM(S): Escherichia Coli 
2024-02-26 | PXD041341 | JPOST Repository
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