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MetabolomicsBone loss with aging is independent of gut microbiome in mice.

Emerging evidence suggests a significant role of gut microbiome in bone health. Aging is well recognized as a crucial factor influencing the gut microbiome. In this study, we investigated whether age-dependent microbial change contributes to age-related bone loss in CB6F1 mice. The bone phenotype...

2024-09-06 | MTBLS10321 | MetaboLights
ProteomicsIn-depth and reproducibly quantitation of benchmark dataset consiting of 20 files
We prepared a benchmark dataset where the various levels of spikeed-in E. Coli proteome that true fold change (i.e. 1 fold, 1.5 fold, 2 fold, 2.5 fold and 3 fold) and true identities of positives/negatives (i.e. E.Coli proteins are true positives while Human proteins are true negatives) are known. T...
ORGANISM(S): Homo sapiens (Human) 
2017-04-20 | PXD005590 | Pride
Lc-ms Human E.coli 
ProteomicsQuantitative Proteomics Benchmark Dataset to evaluate label-free quantitative methods- LC/Orbitrap Fusion MS analysis of E coli proteomes spiked-in Human proteins at 5 different levels (N=20)
To unbiasedly evaluate the quantitative performance of different quantitative methods, and compare different popular proteomics data processing workflows, we prepared a benchmark dataset where the various levels of spikeed-in E. Coli proteome that true fold change (i.e. 1 fold, 1.5 fold, 2 fold, 2....
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2018-05-16 | PXD003881 | Pride
Human Label-free Ionstar Ecoli Benchmark Orbitrap fusion 
MetabolomicsIntegrated transcriptome and metabolome analysis reveals the regulatory mechanism underlying fluoride tolerance in XSKD silkworm strain
XueSong KD (XSKD) is a fluoride-tolerant Bombyx mori strain that grows normally under long-term fluoride exposure, whereas its molecular tolerance mechanism remains elusive. Herein, we performed combined transcriptomic and untargeted metabolomic profiling using pre-molt fourth-instar XSKD larvae fed...
2026-07-07 | MTBLS14966 | MetaboLights
UnknownA rapid and high sensitivity RNA detection based on NASBA and G4-ThT fluorescent biosensor.
Not available
S-EPMC9203706 | biostudies-literature
ProteomicsHuman pancreatic cancer LC-MSMS
Despite decades of effort, pancreatic adenocarcinoma (PDAC) remains an intractable clinical challenge. An insufficient understanding of mechanisms underlying tumor cell responses to chemotherapy contributes significantly to the lack of effective treatment regimens. Here, paclitaxel, a first-line che...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-08-31 | MSV000082878 | MassIVE
ProteomicsHuman urinary extracellular vesicles protein LC-MS/MS
Urinary extracellular vesicles (uEV) are a precious new source of biomarkers reflecting the physiological state of the upstream parent cells and organ systems. However, urinary Tamm-Horsfall Protein (THP; uromodulin) interferes heavily with all vesicle isolation attempts, precipitates with normal ur...
ORGANISM(S): Homo sapiens (Human) 
2019-09-30 | PXD013429 | Pride
Urea Mass spectrometry Tamm-horsfall protein Urinary extracellular vesicle Biomarker 
TranscriptomicsSIRT6 regulates redox homeostasis in human mesenchymal stem cells by the transactivation of NRF2
We investigated the effect of SIRT6-knockout on gene expression and H3K4me3 modification profile in human mesenchymal stem cells. RNAs isolated from SIRT6+/+ and SIRT6-/- hMSCs at early and late passages were sequenced, respectively. And, H3K4me3 ChIP-seq was performed upon the SIRT6 deleted hMSC an...
ORGANISM(S): Homo sapiens 
2016-01-04 | E-GEOD-64642 | biostudies-arrayexpress
ProteomicsKDM6A downregulation promotes tumor-prone cytokines expression in cancer-associated fibroblasts by activating enhancers
co-IP assays demonstrate that KDM6A is bound to WDR5, facilitating its association with the COMPASS complex and the polycomb repressive complex at the expected target loci.
ORGANISM(S): Homo Sapiens 
2024-12-04 | PXD058594 |
GenomicsA Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging
Our data throw light upon the effect of WRN deficiency on gene expression and epigenomic modification, which indicates aging-associated changes from both genomic and epigenomic level. It was compared between WRN+/+ and WRN-/- in hESCs and hMSCs that the gene expression landscapes and epigenetic modi...
ORGANISM(S): Homo sapiens 
2015-05-13 | E-GEOD-52285 | biostudies-arrayexpress
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