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ProteomicsAblation or Inhibition of Protein Disulfide Isomerase A3 (PDIA3) in Aberrant Club Cells Attenuates Osteopontin (SPP1) Production and Pulmonary Fibrosis
Rationale: The role of club cells in the pathology of Idiopathic Pulmonary Fibrosis IPF is not well understood. PDIA3, an endoplasmic reticulum (ER) based redox chaperone catalyzes the cysteine disulfide bonds (-S-S-) in various fibrosis-related proteins; however, mechanisms of action of PDIA3 in pu...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-11 | PXD021715 | Pride
Ipf Pdia3 Osteopontin Upr Pulmonary fibrosis Loc14 Spectral counting Ccsp Lc-ms/ms 
ProteomicsTargeting mitochondrial reactive oxygen species alleviates allergic airway disease in a mouse model of obese allergic asthma
Obesity is associated with severe, difficult to control asthma, and increased airway oxidative stress. Mitochondrial reactive oxygen species (mROS) are an important source of oxidative stress leading us to hypothesize that targeting mROS in obese allergic asthma might be an effective treatment strat...
ORGANISM(S): Bos taurus (Bovine) Mus musculus (Mouse) 
2023-06-02 | PXD029715 | Pride
Obesity Mitochondrial reactive oxygen species (mros) Allergic asthma Airway oxidome Unfolded protein response (upr). Mitoquinone Tissue eosinophilia 
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