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ProteomicsMutant PDIA3 causes neurodevelopmental impairment by disturbing endoplasmic reticulum proteostasis
Identification of a disease gene enables the elucidation of the gene function in biological networks. Here we report homozygous c.170G>A (p.Cys57Tyr or C57Y) in protein disulfide isomerase A3 (PDIA3) causing syndromic intellectual disability. PDIA3 catalyzes the formation of disulfide bonds in the e...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-25 | PXD026507 | Pride
Intellectual disability / cell adhesion / actin cytoskeleton / integrins / protein disulfide isomerase 
ProteomicsAblation or Inhibition of Protein Disulfide Isomerase A3 (PDIA3) in Aberrant Club Cells Attenuates Osteopontin (SPP1) Production and Pulmonary Fibrosis
Rationale: The role of club cells in the pathology of Idiopathic Pulmonary Fibrosis IPF is not well understood. PDIA3, an endoplasmic reticulum (ER) based redox chaperone catalyzes the cysteine disulfide bonds (-S-S-) in various fibrosis-related proteins; however, mechanisms of action of PDIA3 in pu...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-11 | PXD021715 | Pride
Ipf Pdia3 Osteopontin Upr Pulmonary fibrosis Loc14 Spectral counting Ccsp Lc-ms/ms 
TranscriptomicsProtective Role for the Disulfide Isomerase PDIA3 in Methamphetamine Neurotoxicity
Methamphetamine abuse continues to be a worldwide problem, damaging the individual user as well as society. Only minimal information exists on molecular changes in the brain that result from methamphetamine administered in patterns typical of human abusers. In order to investigate such changes, we e...
ORGANISM(S): Macaca mulatta 
2011-11-15 | GSE33707 | GEO
TranscriptomicsProtective Role for the Disulfide Isomerase PDIA3 in Methamphetamine Neurotoxicity
Methamphetamine abuse continues to be a worldwide problem, damaging the individual user as well as society. Only minimal information exists on molecular changes in the brain that result from methamphetamine administered in patterns typical of human abusers. In order to investigate such changes, we e...
ORGANISM(S): Macaca mulatta 
2011-11-15 | E-GEOD-33707 | biostudies-arrayexpress
UnknownERp57/PDIA3: new insight.
Not available
S-EPMC8809632 | biostudies-literature
UnknownImpaired bone formation in Pdia3 deficient mice.
Not available
S-EPMC4236091 | biostudies-literature
UnknownExpression and Prognostic Significance of PDIA3 in Cervical Cancer.
Not available
S-EPMC9674421 | biostudies-literature
UnknownProtein Disulfide Isomerase A3 (PDIA3): A Pharmacological Target in Glioblastoma?
Not available
S-EPMC10488224 | biostudies-literature
UnknownPDIA3 Expression in Glioblastoma Modulates Macrophage/Microglia Pro-Tumor Activation.
Not available
S-EPMC7662700 | biostudies-literature
UnknownProtective role for the disulfide isomerase PDIA3 in methamphetamine neurotoxicity.
Not available
S-EPMC3371042 | biostudies-literature
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