Sort   by:  
 Page size 
TranscriptomicsClara cell regulation of the inflammatory response
Chronic lung diseases are marked by excessive inflammation and epithelial remodeling. Reduced Clara cell secretory function and corresponding decreases in the abundance of the major Clara cell secreted protein, CCSP, are characteristically seen in these disease states. We sought to define the impact...
ORGANISM(S): Mus musculus 
2010-05-18 | E-GEOD-16409 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of lung alveolar type II epithelial cells from CCSP-rtTA/(teto)7Stat3C bitransgenic mice treated with doxycycline and with spontaneous lung bronchoalveolar adenocarcinoma
Over-expression of Stat3C in lung alveolar type II epithelial cells of CCSP-rtTA/(teto)7Stat3C bitransgenic mice leads to severe pulmonary inflammation in the lung. As a consequence, spontaneous lung bronchoalveolar adenocarcinoma was observed in bitransgenic mice. Aberrantly expressed genes in th...
ORGANISM(S): Mus musculus 
2008-05-07 | E-MEXP-1137 | biostudies-arrayexpress
UnknownDepletion of bone marrow CCSP-expressing cells delays airway regeneration.
Not available
S-EPMC4351456 | biostudies-literature
TranscriptomicsTranscription profiling of mouse lung tumor tissue from TI-K (CCSP-rtTA;TRE-KrasV12), TI-KM (CCSP-rtTA; TRE-KrasV12; TRE-Mad2), recurrence (TI-KM) or normal lung tissue (CCSP-rtTA) reveals Mad2-induced chromosome instability leads to lung tumor relapse after oncogene withdrawal
Inhibition of an initiating oncogene often leads to extensive tumor cell death, a phenomenon known as oncogene addiction. This has led to the search for compounds that specifically target and inhibit oncogenes as anti-cancer agents. Whether chromosomal instability (CIN) generated as a result of dere...
ORGANISM(S): Mus musculus 
2010-01-22 | E-GEOD-19753 | biostudies-arrayexpress
GenomicsTranscriptomic Analysis of A549 cells (CC), corresponding 40 Gy radioresistant (RR) cells and respective tumorosphere cells (CCsp and RRsp)
Transcriptomic Analysis of A549 cells (CC), corresponding 40 Gy radioresistant (RR) cells and respective tumorosphere cells (CCsp and RRsp)
PRJNA916222 | ENA
TranscriptomicsTranscription profiling of dox-inducible, bitransgenic Ccsp-rtta x Teto-fgf7 mice lungs to 1 and 3 days of doxycycline treatment
Response of dox-inducible, bitransgenic Ccsp-rtta x Teto-fgf7 mice to 1 and 3 days of doxycycline treatment
ORGANISM(S): Mus musculus 
2022-11-22 | E-MEXP-644 | biostudies-arrayexpress
UnknownA subset of epithelial cells with CCSP promoter activity participates in alveolar development.
Not available
S-EPMC3135842 | biostudies-literature
TranscriptomicsTranscriptomic Analysis of A549 cells (CC), corresponding 40 Gy radioresistant (RR) cells and respective tumorosphere cells (CCsp and RRsp)
Initially radio-resistant cell line (40 Gy RR) was generated by treating A549 clonogenic cells with a dose of 5 Gy/fraction eight times. We then evaluated Transcriptomic analysis of A549 cells (CC), generated radioresistant cells (RR) and respective tumorospheroids of A549 and radioresistant cells (...
ORGANISM(S): Homo sapiens 
2024-12-25 | GSE221796 | GEO
ProteomicsAblation or Inhibition of Protein Disulfide Isomerase A3 (PDIA3) in Aberrant Club Cells Attenuates Osteopontin (SPP1) Production and Pulmonary Fibrosis
Rationale: The role of club cells in the pathology of Idiopathic Pulmonary Fibrosis IPF is not well understood. PDIA3, an endoplasmic reticulum (ER) based redox chaperone catalyzes the cysteine disulfide bonds (-S-S-) in various fibrosis-related proteins; however, mechanisms of action of PDIA3 in pu...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-11 | PXD021715 | Pride
Ipf Pdia3 Osteopontin Upr Pulmonary fibrosis Loc14 Spectral counting Ccsp Lc-ms/ms 
TranscriptomicsClara cell regulation of the inflammatory response
Chronic lung diseases are marked by excessive inflammation and epithelial remodeling. Reduced Clara cell secretory function and corresponding decreases in the abundance of the major Clara cell secreted protein, CCSP, are characteristically seen in these disease states. We sought to define the impact...
ORGANISM(S): Mus musculus 
2009-06-04 | GSE16409 | GEO
Sort   by:  
 Page size