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ProteomicsStructural and mechanistic insights into the CAND1-mediated SCF substrate receptor exchange
Modular SCF (SKP1-CUL1-Fbox) ubiquitin E3 ligases orchestrate multiple cellular pathways in eukaryotes. Their variable SKP1-Fbox substrate receptor (SR) modules enable regulated substrate recruitment and subsequent proteasomal degradation. CAND proteins are essential for the efficient and timely exc...
ORGANISM(S): Homo sapiens (Human) 
2023-09-18 | PXD042178 | Pride
Human Cand1 Cryo-em Hdx-ms 
ProteomicsCullin-associated and neddylation-dissociated protein 1 (CAND1) alleviates NAFLD by reducing ubiquitinated degradation of ACAA2
Nonalcoholic fatty liver disease (NAFLD) is the most common liver disorder with high morbidity and mortality. The current study aims to explore the role of Cullin-associated and neddylation-dissociated protein 1 (CAND1) in the development of NAFLD and the underlying mechanisms. CAND1 is reduced in t...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD043719 | Pride
Lc-msms L02 cell 
ProteomicsProteomic analyses identify ANP32A and CAND1 as androgen receptor and splice variant coactivators, whose interactions are regulated by DNA-dependent protein kinase
ARv7, the most prevalent androgen receptor (AR) variant in castration resistant prostate cancer (CRPC), lacks the AR ligand binding domain (LBD) making it resistant to LBD-targeting pharmacological inhibitors, such as enzalutamide. Identifying new prostate cancer therapeutic targets by defining key ...
ORGANISM(S): Homo sapiens (Human) 
2026-04-06 | PXD021462 | Pride
Prostate cancer Coregulators And cand1 Dna-dependent protein kinase Androgen receptor Androgen receptor splice variant Anp32a 
TranscriptomicsThe Hace1 E3 Ligase Modulates the Activity of Multiple Tumor Suppressive CRL E3 Ligases by binding to CAND1
The Hace1 E3 ligase is a tumor suppressor in stressed cells. Through unknown mechanisms, Hace1 indirectly targets the cyclin D1 proto-oncogene for proteasomal degradation during nutrient depletion. We now show that Hace1 targets HIF1alpha for VHL-dependent degradation during hypoxia. To better under...
ORGANISM(S): Homo sapiens 
2011-07-01 | E-GEOD-25452 | biostudies-arrayexpress
ProteomicsSystemwide disassembly and assembly of SCF ubiquitin ligase complexes
Cells adapt to ever-changing environmental cues by remodeling their inventories of multiprotein complexes. The cellular repertoire of modular multiprotein SCF (SKP1-CUL1-Fbox protein) E3 ligase complexes - which mediate much protein degradation - requires CAND1 to distribute the limiting CUL1 subuni...
ORGANISM(S): Homo sapiens (Human) 
2023-04-14 | PXD038661 | Pride
Crl Ligase Cand1 Scf Formation Assembly Ubiquitin Complex E3 
UnknownGenetic analysis of CAND1-CUL1 interactions in Arabidopsis supports a role for CAND1-mediated cycling of the SCFTIR1 complex.
Not available
S-EPMC2448860 | biostudies-literature
ProteomicsSILAC proteomics studying the role of CAND1 in CRL2 dynamics
Effects of CAND1 and neddylation/deneddylation on CRL2 dynamics.
ORGANISM(S): Homo sapiens (Human) 
2023-12-18 | PXD045609 | Pride
Cul2 exchange 
UnknownThe Impact of Cand1 in Prostate Cancer.
Not available
S-EPMC7072594 | biostudies-literature
UnknownCAND1 mediates CUL7-dependent HER2 protein stability to drive breast cancer progression.
Not available
S-EPMC12659323 | biostudies-literature
ProteomicsDynamic exchange of CRL4 regulated by CAND1 and CAND2
CAND1 and CAND2 have been established as exhange factors for CRL1s, however, how they regulate the dynamic exchange of CRL4s remains not fully understood. This project aims to study and compare the effect of CAND proteins on the exchange levels of multiple DCAFs, thus providing insights into the fun...
ORGANISM(S): Homo sapiens (Human) 
2026-02-12 | PXD063817 | Pride
Silac  human  cullin-ring ubiquitin ligases 
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