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ProteomicsSubcellular proteomics combined with bioenergetic phenotyping reveals protein biomarkers of respiratory insufficiency in the setting of compromised mitochondrial DNA repair.
The mitochondrial mutator mouse is a well-established model of premature aging in which a progeroid phenotype is driven by the accumulation of somatic mtDNA mutations. Despite evidence of bioenergetic disruption within the cardiac mitochondria, there is little information about the underlying change...
ORGANISM(S): Mus Musculus (mouse) 
2021-01-08 | PXD017000 | JPOST Repository
ProteomicsAggregation of respiratory complex subunits marks the onset of proteotoxicity in proteasome inhibited cells
Proteostasis is maintained by optimum expression, folding, transport, and clearance of proteins. Deregulation of any of these processes triggers protein aggregation and is implicated in many age-related pathologies. Here, using quantitative proteomics and microscopy we show that aggregation of many ...
ORGANISM(S): Mus musculus (Mouse) 
2019-01-28 | PXD012204 | Pride
Proteomics Proteostasis Mitochondrial respiratory chain complex Low complexity region Protein turnover Mitochondria Protein misfolding Protein aggregation 
ProteomicsPreserved respiratory chain capacity and physiology in mice with profoundly reduced levels of mitochondrial respirasomes
The mammalian respiratory chain complexes I, III2 and IV (CI, CIII2 and CIV) are critical for cellular bioenergetics and form a stable assembly, the respirasome (CI-CIII2-CIV), that is biochemically and structurally well documented. The role of the respirasome in bioenergetics and regulation of meta...
ORGANISM(S): Mus musculus (Mouse) 
2024-03-19 | PXD023846 | Pride
Tmt Supercomplex Oxphos Mitochondria Complexome profiling 
ProteomicsMitochondrial proteome analysis reveals that an augmented cytochrome c oxidase assembly and activity potentiates respiratory capacity in sarcoma
Sarcoma is a type of cancer that developed from transformed mesenchymal cells like bone, cartilage, fat, muscle, etc. and is broadly categorized into two types, bone and soft tissue sarcoma. Solid tumor cells rely on glycolysis for energy production, contrary to the general belief, it was previously...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-17 | PXD044903 | Pride
Sarcoma And respiratory chain subunits Differential proteomics Mitochondria 
TranscriptomicsmRNA expression profiling of mitochondrial subunits in subjects with Parkinson’s disease
Introduction: Parkinson's disease (PD), typically developing between the ages of 55 and 65 years, is a common neurodegenerative disorder caused by a progressive loss of dopaminergic neurons due to the accumulation of α-synuclein in the substantia nigra. Mitochondria are known to play a key role in c...
ORGANISM(S): Homo sapiens 
2022-01-01 | E-MTAB-9950 | biostudies-arrayexpress
ProteomicsSodium carbonate extraction mass spectrometry reveals novel steps in mitochondrial respiratory chain complex III assembly
Mitochondria are complex organelles containing 13 proteins encoded by mitochondrial DNA and over 1000 proteins encoded on nuclear DNA. Many mitochondrial proteins are associated with the inner or outer mitochondrial membranes, either peripherally or as integral membrane proteins, while others reside...
ORGANISM(S): Homo sapiens (Human) 
2022-03-23 | PXD028935 | Pride
Proteomic analysis Mitochondria Oxphos (oxidative phosphorylation) Carbonate extraction Respiratory chain assembly Membrane protein 
ProteomicsSalvage pathway maintains functional respiratory complex I
Regulation of the turnover of complex I (CI), the largest mitochondrial respiratory chain complex remains enigmatic, despite huge advancement in understanding its structure and the assembly steps in recent years. Although some studies indicated that CI might be remodelled in response to various stim...
ORGANISM(S): Mus musculus (Mouse) 
2020-03-05 | PXD014897 | Pride
Mitochondrial respiratory complex i  proteolytic control  salvage pathway  respiratory deficiency  clpxp protease 
UnknownA splendid molecular factory: De- and reconstruction of the mammalian respiratory chain.
Not available
S-EPMC11962478 | biostudies-literature
ProteomicsMitochondrial microproteins link metabolic cues to respiratory chain biogenesis
Electron transport chain (ETC) biogenesis is tightly coupled to energy levels and availability of ETC subunits. Coenzyme Q: cytochrome c oxidoreductase (complex III or CIII) occupies a central position in the ETC, receiving electrons from diverse fuel sources to control the ubiquinol:ubiquinone (CoQ...
ORGANISM(S): Mus musculus (Mouse) 
2022-09-25 | PXD030258 | Pride
Metabolism Sep Mitochondria Oxphos Micropeptides 
UnknownNuclear respiratory factor 1 controls myocyte enhancer factor 2A transcription to provide a mechanism for coordinate expression of respiratory chain subunits.
Not available
S-EPMC2335360 | biostudies-literature
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