Sort   by:  
 Page size 
MetabolomicsSpermine is a natural suppressor of AR signaling in castration-resistant prostate cancer
In castration-resistant prostate cancer (CRPC), clinical response to androgen receptor (AR) antagonists is limited mainly due to AR-variants expression and restored AR signaling. The metabolite spermine is most abundant in prostate and it decreases as prostate cancer progresses, but its functions re...
2023-10-11 | MTBLS8034 | MetaboLights
ProteomicsThe effects of enzalutamide on androgen-dependent and androgen-independent prostate cancer cells.
To investigate the mechanisms of drug resistance and castration resistance in prostate cancer, we performed proteomic sequencing on androgen-dependent prostate cancer cells (LNCaP) and androgen-independent cells (AI) treated with enzalutamide.
ORGANISM(S): Homo Sapiens 
2024-11-26 | PXD058261 |
TranscriptomicsIdentification of novel androgen-responsive genes by sequencing of LongSAGE libraries
Background: The development and maintenance of the prostate is dependent on androgens and the androgen receptor. The androgen pathway continues to be important in prostate cancer. Here, we evaluated the transcriptome of prostate cancer cells in response to androgen using long serial analysis of gene...
ORGANISM(S): Homo sapiens 
2009-10-20 | E-GEOD-18401 | biostudies-arrayexpress
TranscriptomicsElk1 Directs a Critical Component of Growth Signaling by the Androgen Receptor in Prostate Cancer
Elk1 directs selective gene induction that is a substantial and critical component of growth signaling by AR in PC cells. Gene expression in LNCaP cells was determined in androgen-depleted medium in response to R1881 in ELK1 knock down (via AR shRNA) or in cells treated with control shRNA.
ORGANISM(S): Homo sapiens 
2013-05-02 | E-GEOD-34589 | biostudies-arrayexpress
ProteomicsAn androgen signaling axis uses a writer and a reader of ADP-ribosylation to control protein complex assembly
Androgen signaling through the androgen receptor (AR) regulates multiple pathways in both normal and prostate cancer cells. Androgen regulates diverse aspects of the AR life cycle, including its post-translational modification, but understanding how specific modifications influence AR activity has b...
ORGANISM(S): Homo sapiens (Human) 
2021-04-23 | PXD025195 | Pride
Human Lc-ms Androgen receptor Mono-adp ribosyltransferase 
ProteomicsAn androgen signaling axis uses a writer and a reader of ADP-ribosylation to control protein complex assembly
Androgen signaling through the androgen receptor (AR) regulates multiple pathways in both normal and prostate cancer cells. Androgen regulates diverse aspects of the AR life cycle, including its post-translational modification, but understanding how specific modifications influence AR activity has b...
ORGANISM(S): Homo sapiens (Human) 
2021-05-28 | PXD018811 | Pride
Mono-adp-ribosyltransferase Parp7 Parp9 Macrodomain Tiparp Dtx3l Androgen receptor Olaparib 
GenomicsDual Role of FoxA1 in Androgen Receptor Binding to Chromatin, Androgen Signaling and Prostate Cancer [ChIP_seq, DHS_seq]
We report the dual role of FoxA1 in androgen receptor recruitment to the chromatin of androgen responsive prostate cancer cell line LNCaP-1F5 using ChIP-sequencing. Depletion of FoxA1 reprograms both androgen and glucocorticoid receptor recruitment and subsequent gene expression. The ChIP-seq has be...
ORGANISM(S): Homo sapiens 
2011-09-14 | E-GEOD-30623 | biostudies-arrayexpress
TranscriptomicsIdentification of an SRF- and androgen-dependent gene signature in prostate cancer
The androgen receptor (AR) is the principal target for treatment of non-organ confined prostate cancer (PCa). Systems and bioinformatics approaches suggest that considerable variation exists in the mechanisms by which AR regulates expression of effector genes and point towards a role for secondary ...
ORGANISM(S): Homo sapiens 
2011-02-28 | E-GEOD-22606 | biostudies-arrayexpress
GenomicsPersistent androgen receptor-mediated transcription in castration-resistant prostate cancer under androgen-deprived conditions
The androgen receptor (AR) is a ligand-inducible transcription factor that mediates androgen action in target tissues. Upon ligand binding, the AR binds to thousands of genomic loci and activates a cell-type specific gene program. Prostate cancer growth and progression depend on androgen-induced AR ...
ORGANISM(S): Homo sapiens 
2012-10-02 | E-GEOD-40050 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human prostate samples LNCaP cell gene expression during 12 months of androgen deprivation, time series
Following androgen ablation therapy (AAT), the vast majority of prostate cancer patients develop treatment resistance with a median time of 18-24 months to disease progression. To identify molecular targets that aid in prostate cancer cell survival and contribute to the androgen independent phenotyp...
ORGANISM(S): Homo sapiens 
2008-04-07 | E-GEOD-8702 | biostudies-arrayexpress
Sort   by:  
 Page size