Sort   by:  
 Page size 
ProteomicsEffects of hypoxia on antigen presentation and T cell-based immune recognition of HPV16-transformed cells
Attempts to develop a therapeutic vaccine against human papillomavirus (HPV)-induced malignancies have not been clinically successful to date. One reason may be the hypoxic microenvironment present in most tumors, including cervical cancer. Hypoxia dysregulates the levels of human leukocyte antigen ...
ORGANISM(S): Homo sapiens (Human) 
2022-11-16 | PXD032217 | Pride
Antigen presentation machinery (apm) Cytotoxic cd8+ t cells Hpv16 
ProteomicsDeleterious knock-outs in the HLA class I antigen processing and presentation machinery induce distinct changes in the immunopeptidome
The human leukocyte antigen (HLA) processing and presentation machinery (APPM) is altered in various diseases and in response to drug treatments. Defects in the machinery may change presentation levels or alter the repertoire of presented peptides, globally or in an HLA allele restricted manner, wit...
ORGANISM(S): Homo sapiens (Human) 
2025-04-04 | PXD056426 | Pride
Immunopeptidomics Antigen presentation 
ProteomicsCT26 Proteome and Immunopeptidome treated with Ionizing Radiation
This project explored the relationship between ionizing radiation and antigen presentation using both proteomic and immunopeptidomics methodologies. We investigated the radiation-specific changes which occur in the colorectal tumor cell proteome associated with changes in dose and time after irradia...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-04 | PXD032003 | Pride
Interferon signaling Ligandomics Mhc Ionizing radiation Immunopeptidomics 
ProteomicsProteomic analysis uncovers common effects of IFN-γ and IL-27 on antigen presentation machinery components in human cancer cells
IL-27, a member of the IL-12- family of cytokines, has shown anti-tumor activity in several pre-clinical models due to anti-proliferative, anti-angiogenic and immune-enhancing effects. On the other hand, IL-27 demonstrated immune-regulatory activities and inhibition of auto-immunity in mouse models....
ORGANISM(S): Homo sapiens (Human) 
2017-05-19 | PXD004419 | Pride
Antigen presentation machinery. Il-27 Interferon gamma  proteomic analysis  hla class i  apm Interleukin-27  ifn-γ 
ProteomicsProteomic analysis of regulated dendritic cell endosomes reveals dynamic adaptation to antigen uptake and cross-presentation
MHC class I cross-presentation involves final proteolytic peptide processing by the endosomal insulin-regulated aminopeptidase (IRAP). Reasoning that analysis of the IRAP proximal proteome may inform about dynamic remodeling of a key cross-presentation compartment during antigen uptake, we developed...
ORGANISM(S): Mus musculus (Mouse) 
2026-02-09 | PXD067092 | Pride
Endosome Insulin-regulated aminopeptidase Proximity biotinylation Cross-presentation Dendritic cell 
TranscriptomicsEpigenetic regulations in the IFNM-NM-3 signalling pathway: IFNM-NM-3-mediated MHC class I upregulation on tumour cells is associated with DNA demethylation of antigen-presenting machinery genes [TC1A9_DAC]
Reversible MHC class I deficiency on tumour cells is commonly caused by coordinated silencing of antigen-presenting machinery genes and restorable by IFNM-NM-3. Here we describe association of DNA demethylation of selected antigen-presenting machinery gene regulatory regions located in the MHC geno...
ORGANISM(S): Mus musculus 
2014-12-08 | E-GEOD-53466 | biostudies-arrayexpress
TranscriptomicsEpigenetic regulations in the IFNM-NM-3 signalling pathway: IFNM-NM-3-mediated MHC class I upregulation on tumour cells is associated with DNA demethylation of antigen-presenting machinery genes [TC1A9_IFN]
Reversible MHC class I deficiency on tumour cells is commonly caused by coordinated silencing of antigen-presenting machinery genes and restorable by IFNM-NM-3. Here we describe association of DNA demethylation of selected antigen-presenting machinery gene regulatory regions located in the MHC geno...
ORGANISM(S): Mus musculus 
2014-12-08 | E-GEOD-53467 | biostudies-arrayexpress
TranscriptomicsEpigenetic regulations in the IFNM-NM-3 signalling pathway: IFNM-NM-3-mediated MHC class I upregulation on tumour cells is associated with DNA demethylation of antigen-presenting machinery genes [RVPC3_DAC]
Reversible MHC class I deficiency on tumour cells is commonly caused by coordinated silencing of antigen-presenting machinery genes and restorable by IFNM-NM-3. Here we describe association of DNA demethylation of selected antigen-presenting machinery gene regulatory regions located in the MHC geno...
ORGANISM(S): Mus musculus 
2014-12-08 | E-GEOD-53465 | biostudies-arrayexpress
GenomicsAtractylenolide I enhances responsiveness to immune checkpoint blockade therapy by activating tumor antigen presentation
Atractylenolide I enhances responsiveness to immune checkpoint blockade therapy by activating tumor antigen presentation
PRJNA718568 | ENA
GenomicsPreclinical model of anti-PDL1 Immune-checkpoint blockade (ICB) resistance in breast cancer associated to low antigen presentation machinery (APM)
Preclinical model of anti-PDL1 Immune-checkpoint blockade (ICB) resistance in breast cancer associated to low antigen presentation machinery (APM)
PRJNA736735 | ENA
Sort   by:  
 Page size