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Metabolomics3,4-Dihydroxybenzaldehyde exerts anti-Alzheimer's effects by inhibiting Aβ protofibril assembly and activating antioxidant defense mechanisms

Broad-spectrum metabolomic analyses reveal that DBD markedly modulates the nematode’s metabolic profile. DBD enhances the activation of transcription factors DAF-16/FOXO and SKN-1/Nrf2, increasing resistance to oxidative and thermal stress. These findings suggest that DBD possesses multi-target t...

2025-12-24 | MTBLS13568 | MetaboLights
MetabolomicsOvothiol A is the Main Antioxidant in Fish Lens
Tissue protection from oxidative stress by antioxidants is of vital importance for cellular metabolism. The lens mostly consists of fiber cells lacking nuclei and organelles, having minimal metabolic activity; therefore, the defense of the lens tissue from the oxidative stress strongly relies on met...
2019-07-30 | MTBLS806 | MetaboLights
MetabolomicsHow Does the Seed Pre-germinative Metabolism Fight against Imbibition Damage? Emerging Roles of Fatty Acid Cohort and Antioxidant Defence

During seed imbibition, lipids are engaged in membrane reorganization while facing free radical-mediated oxidative injury. In the present work, we explored changes in lipid components at different timepoints of imbibition (0.5, 2, 4, 6, and 8 h) in the legume Medicago truncatula, by combining bio...

2019-10-14 | MTBLS181 | MetaboLights
MetabolomicsA Metabolic Profiling Strategy for the Dissection of Plant Defense against Fungal Pathogens (DI-MS assays)
Here we present a metabolic profiling strategy employing direct infusion Orbitrap mass spectrometry (MS) and gas chromatography-mass spectrometry (GC/MS) for the monitoring of soybean's (Glycine max L.) global metabolism regulation in response to Rhizoctonia solani infection in a time-course. Key el...
2014-11-15 | MTBLS117 | MetaboLights
MetabolomicsA Metabolic Profiling Strategy for the Dissection of Plant Defense against Fungal Pathogens (GC-MS assay)
Here we present a metabolic profiling strategy employing direct infusion Orbitrap mass spectrometry (MS) and gas chromatography-mass spectrometry (GC/MS) for the monitoring of soybean's (Glycine max L.) global metabolism regulation in response to Rhizoctonia solani infection in a time-course. Key el...
2014-11-15 | MTBLS118 | MetaboLights
MetabolomicsAcute response to a high-saturated, high-refined carbohydrate meal in healthy young men shows novel perturbation of multiple metabolic and defense pathways

Regular consumption of fat and refined carbohydrates induces metabolic stress, increasing chronic metabolic disease risk. In healthy volunteers, we characterised the response to a high-fat/high-carbohydrate meal (HFHCM), typical of an ultra-processed food, by proteomic and metabolomics analyses, ...

2026-04-02 | MTBLS10972 | MetaboLights
MetabolomicsAntioxidant Activity, Phytochemical Profiling by UPLC-QTOF-MS, and In Silico Targeting of the RNA-Binding Protein DRBD18 of Trypanosoma brucei by Bioactive Compounds from Tetradenia riparia and Tetracera poggei
Oxidative stress plays a key role in the pathogenesis of African trypanosomiasis, and plant-derived antioxidants represent a promising source of dual-action compounds capable of both scavenging reactive oxygen species and interfering with parasite survival. The present study investigates the antioxi...
2026-09-10 | MTBLS15597 | MetaboLights
ProteomicsChios Mastic Gum Extract Enhances Antioxidant Defense in Zebrafish
Chios mastic gum (CMG), derived from the resin of the Pistacia lentiscus has long been considered a natural remedy in the Mediterranean region. Its anti-inflammatory and an-tioxidant properties have garnered increasing attention from scientists and consumers over recent decades. While substantial ev...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2025-12-22 | PXD070358 | Pride
Chios mastic gum  zebrafish  proteomics  copper-zinc superoxide dismutase  thioredox-in-disulfide reductase  catalase 
ProteomicsHypoxia reveals the new function of Foxn1 in keratinocytes antioxidant defense system
Skin exposed to environmental threats including injuries and oxidative stress developed an efficient but not fully recognized systems of repair and antioxidant protection. In this project we provide evidence that Foxn1 in keratinocytes regulates elements of electron transport chain and participates ...
ORGANISM(S): Mus musculus (Mouse) 
2022-07-08 | PXD031125 | Pride
Thioredoxin system Skin Foxn1 Keratinosytes Hypoxia 
TranscriptomicsTranscription profiling of human blood taken from individuals fed an antioxidant-rich diet or a diet containing kiwi-fruit to evaluate the effect on gene expression with emphasis on stress and repair related processes
Plant-based diets rich in fruit and vegetables can prevent development of several chronic age-related diseases such as cancer and cardiovascular diseases. The mechanisms behind this protective effect is not elucidated. We have studied whether a specially designed antioxidant-rich food diet and a kiw...
ORGANISM(S): Homo sapiens 
2010-02-02 | E-MEXP-2030 | biostudies-arrayexpress
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