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MetabolomicsGut Microbiota–Derived Ergothioneine Alleviates Antipsychotic-Induced Synaptic and Cognitive Impairments

Background: Chronic use of antipsychotic drugs is associated with neuronal damage and cognitive impairment, potentially mediated by alterations in gut microbiota metabolites, although the specific metabolite involved remains unknown.

Objective: To identify the key metabolite responsible for...

2026-04-08 | MTBLS12751 | MetaboLights
TranscriptomicsA gene co-expression network in whole blood of schizophrenia patients is independent of antipsychotic-use and enriched for brain-expressed genes
This SuperSeries is composed of the following subset Series: GSE38481: A gene co-expression network in whole blood of schizophrenia patients is independent of antipsychotic-use and enriched for brain-expressed genes [HumanRef-8 v3.0] GSE38484: A gene co-expression network in whole blood of schizophr...
ORGANISM(S): Homo sapiens 
2012-07-08 | E-GEOD-38485 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse frontal cortex after treatment with zntipsychotic drugs
Antipsychotic drugs are classified as typical and atypical based on extrapyramidal effects. However, since the frontal cortex is one of the most important regions for antipsychotic actions, this study attempted to classify antipsychotic drugs based on gene expression in the frontal cortex. Chlorprom...
ORGANISM(S): Mus musculus 
2008-06-12 | E-GEOD-1501 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of brain samples from human control and schizophrenia patients who were treated with either typical, atypical or no antipsychotic medication
Multiple studies have shown that brain gene expression is disturbed in subjects suffering from schizophrenia. However, disentangling disease effects from alterations caused by neuroleptics is a challenging task.
To address the issues of disease heterogeneity and the effect of antipsychotic medi...
ORGANISM(S): Homo sapiens 
2007-12-06 | E-MEXP-857 | biostudies-arrayexpress
TranscriptomicsA gene co-expression network in whole blood of schizophrenia patients is independent of antipsychotic-use and enriched for brain-expressed genes [HumanRef-8 v3.0]
Gene expression analyses in whole blood reveal a network of genes related to schizophrenia Weighted gene co-expression analyses applied to human whole blood gene expression data of schizophrenia cases and healthy controls
ORGANISM(S): Homo sapiens 
2012-07-08 | E-GEOD-38481 | biostudies-arrayexpress
TranscriptomicsA gene co-expression network in whole blood of schizophrenia patients is independent of antipsychotic-use and enriched for brain-expressed genes [HumanHT-12 V3.0]
Gene expression analyses in whole blood reveal a network of genes related to schizophrenia Weighted gene co-expression analyses applied to human whole blood gene expression data of schizophrenia cases and healthy controls
ORGANISM(S): Homo sapiens 
2012-07-08 | E-GEOD-38484 | biostudies-arrayexpress
TranscriptomicsUnderstanding pharmaco-epigenomic response of antipsychotic drugs using genome-wide microRNA expression profile in liver cell line
The study is directed to understand the impact of antipsychotic drugs on miRNA expression in liver cell line model
ORGANISM(S): Homo sapiens 
2022-02-08 | E-MTAB-11458 | biostudies-arrayexpress
TranscriptomicsEffects of an antipsychotic (Olanzapine) involves alterations in gene specific DNA methylation
Antipsychotic drugs are commonly used to treat psychosis, mood disorders, and anxiety. While there is indirect evidence that some component of the antipsychotic effect of these drugs may involve modulation of dopamine transmission, their mechanism of action is poorly understood. We hypothesized that...
ORGANISM(S): Rattus norvegicus 
2013-11-22 | E-GEOD-52615 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse brain after twelve week treatment with the antipsychotics Clozapine and Haloperidol
Atypical antipsychotic Clozapine has a superior antipsychotic and antimanic effects compared to other antisphicotics. Its widespread use was limited by the side effects of agranulocytosis, cardiomyopathy and metabolic anomalies such as weight gain, and diabetes. Very little is known about mechanisms...
ORGANISM(S): Mus musculus 
2009-02-07 | E-GEOD-6467 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse brain from animals treated for 4 weeks with the antipsychotics Clozapine and Haloperidol
Atypical antipsychotic Clozapine has a superior antipsychotic and antimanic effects compared to other antisphicotics. Its widespread use was limited by the side effects of agranulocytosis, cardiomyopathy and metabolic anomalies such as weight gain, and diabetes. Very little is known about mechanisms...
ORGANISM(S): Mus musculus 
2009-04-30 | E-GEOD-6511 | biostudies-arrayexpress
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