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TranscriptomicsStrand-specific RNA-seq reveals ordered patterns of sense and antisense transcription in Bacillus anthracis
Although genome-wide transcriptional analysis has been used for many years to study bacterial gene expression, many aspects of the bacterial transcriptome remain undefined. A prominent example is antisense transcription, which has been observed in a number of bacteria, though the function of antise...
ORGANISM(S): Bacillus anthracis 
2012-03-15 | E-GEOD-36506 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of expression and DNA methylation at CpG-island-associated sense-antisense transcript loci in mouse
Sense-antisense transcript (SAT) pairs are pairs of transcripts that fully or partially overlap but are transcribed in opposite directions. Although SAT expression occurs in various species, most SAT pairs have not been examined in detail. Because our previous studies revealed some tissue specificit...
ORGANISM(S): Mus musculus 
2010-08-26 | E-GEOD-14392 | biostudies-arrayexpress
TranscriptomicsEffects of AβPP Antisense Treatment on Hippocampal Gene Expression in Adult Mice with Memory Deficits
The purpose of this study was to determine the effect of peripheral (IV) administration of AβPP antisense on hippocampal gene expression as well as on learning and memory as measured by T-maze in adult male mice aged 12 months. The AβPP antisense treatment reversed learning and memory deficits and ...
ORGANISM(S): Mus musculus 
2015-02-13 | E-GEOD-65877 | biostudies-arrayexpress
TranscriptomicsTranscriptional analysis of select CfMNPV genes and some antisense transcripts by an oligonucleotide microarray
The temporal expression of the 23 CfMNPV genes representing all four temporal classes including its 7 unique genes were determined by a modified oligonucleotide-based two-channel DNA microarray. Transcription of the non-coding (antisense) strands of some of the CfMNPV select genes including the poly...
ORGANISM(S): Choristoneura fumiferana MNPV 
2007-05-01 | E-GEOD-4783 | biostudies-arrayexpress
GenomicsAntisense oligonucleotide therapy for calmodulinopathy
Antisense oligonucleotide therapy for calmodulinopathy
PRJNA1030420 | ENA
TranscriptomicsRho and NusG suppress pervasive antisense transcription in Escherichia coli [RNA-seq].
Despite the prevalence of antisense transcripts in bacterial transcriptomes, little is known about how their synthesis is controlled. We report that a major function of the Escherichia coli termination factor Rho and its co-factor NusG is suppression of ubiquitous antisense transcription genome-wide...
ORGANISM(S): Escherichia coli K-12 
2012-11-01 | E-GEOD-41939 | biostudies-arrayexpress
TranscriptomicsHepatic gene expression changes following antisense oligonucleotide-based inhibition of miR-29a
Adult BALB/c female mice were injected intraperitoneally with a single dose at 20 mg per kg of antisense oligonucleotide either against miR-29a (5’-TAACCGATTTCAGATGGTGCTA-3’) or against a scrambled sequence (5’-TCATTGGCATGTACCATGCAGCT-3’ Antisense oligonucleotides contained 2’-O-methoxyethyl (2’-MOE...
ORGANISM(S): Mus musculus 
2012-08-22 | E-GEOD-40261 | biostudies-arrayexpress
ProteomicsSex-Dependent effects of Sortilin antisense oligonucleotide on Ldlr-/- mice
We evaluated the therapeutic potential of silencing sortilin expression in vivo using antisense oligonucleotide (ASO-Sort1) to reduce atherosclerosis and associated calcification. Male and female Ldl (low-density lipoprotein) receptor deficient mice were fed a high-fat diet and treated with ASO-Sort...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-15 | PXD048883 | Pride
Sortilin Mouse Sex Ldlr Aortic arch Atherosclerosis 
TranscriptomicsAntisense Expression of Annotated Genes
Contains a row for each annotated gene in each sample, indicating whether our analysis called the region antisense to the coding region of the gene "present" or "absent" in the sample. Gene names and coordinates refer to version 3 of the TIGR annotation as submitted to GenBank (GI numbers 22330780, ...
ORGANISM(S): Arabidopsis thaliana 
2010-06-05 | E-GEOD-637 | biostudies-arrayexpress
TranscriptomicsThe effect of temperature on Natural Antisense Transcript (NAT) expression in Aspergillus flavus
Naturally occurring Antisense Transcripts (NATs) compose an emerging group of regulatory RNAs. These regulatory elements appear in all organisms examined, but little is known about global expression of NATs in fungi. Analysis of currently available EST sequences suggests that 352 cis NATs are pres...
ORGANISM(S): Aspergillus flavus 
2010-06-21 | E-GEOD-12594 | biostudies-arrayexpress
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