Antisense oligonucleotide (aso)

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HF liver: Control vs. Plin2-ASO treated

Transcriptional profiling of mouse liver comparing control, scrambled-oligonucleotides (Cont)-treated mice with Perilipin 2-antisense oligonucleotides (Plin2-ASO)-treated mice. C57BL/6 mice on a high-fat diet were treated with oligonucleotides in vivo. The goal was to determine the effects of Plin2 ...

ORGANISM(S): Mus musculus

2012-12-05 | E-GEOD-37011 | biostudies-arrayexpress

Antisense oligonucleotide activity in tumour cells is influenced by intracellular LBPA distribution and 6 extracellular vesicles recycling

Next generation modified antisense oligonucleotides (ASOs) are commercially approved new therapeutic modalities, yet poor productive uptake and endosomal entrapment in tumour cells limit their broad application. We compared intracellular traffic of anti KRAS antisense oligonucleotide (AZD4785) in go...

ORGANISM(S): Homo sapiens (Human)

2021-11-10 | PXD027804 | Pride

Antisense oligonucletides Lc-ms/ms

Sex-Dependent effects of Sortilin antisense oligonucleotide on Ldlr-/- mice

We evaluated the therapeutic potential of silencing sortilin expression in vivo using antisense oligonucleotide (ASO-Sort1) to reduce atherosclerosis and associated calcification. Male and female Ldl (low-density lipoprotein) receptor deficient mice were fed a high-fat diet and treated with ASO-Sort...