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ProteomicsAnalysis of the apical secretome of Calu-3 and NHBE cells in 3D models of the human bronchial epithelium
The mucus secreted by airway epithelial cells plays a key role in the protection against and clearance of particles and pathogens. In this project, a 3D model of the bronchial epithelium was established using Calu-3 cells grown on porous inserts at the air-liquid interface. The secreted proteins wer...
ORGANISM(S): Homo sapiens (Human) 
2021-03-26 | PXD024242 | Pride
Human Lc-msms Calu-3 Nhbe Apical secretome Epithelial cells 
ProteomicsThe secretome profiling of a pediatric airway epithelium infected with hRSV identified aberrant apical/basolateral trafficking and novel immune modulating (CXCL6, CXCL16, CSF3) and antiviral (CEACAM1) proteins.
The respiratory epithelium comprises polarized cells at the interface between the environment and airway tissues. Polarized apical and basolateral protein secretions are a feature of airway epithelium homeostasis. Human respiratory syncytial virus (hRSV) is a major human pathogen that primarily targ...
ORGANISM(S): Homo sapiens (Human) 
2020-02-25 | PXD013661 | Pride
Cxcl16 Secretome directionality Respiratory syncytial virus Well-differentiated pediatric bronchial epithelial cells (wd-pbecs) Ceacam1 Quantitative proteomics Cxcl6 Csf3 
ProteomicsSecretome profiling of human airway epithelial cultures infected with respiratory syncytial virus
The respiratory epithelium is a polarised layer at the interface between the outside environment and deeper lung structures, overlaid by the epithelial lining fluid (ELF). This provides a mechanical and immunological barrier to inhaled particulates, such as viruses. Human respiratory syncytial virus...
ORGANISM(S): Homo sapiens (Human) 
2022-03-01 | PXD004430 | Pride
Human respiratory syncytial virus Human airway epithelial model Secretome Lc-ms/ms 
ProteomicsSecretome and Proteome of WT and CFTR-KO pancreatic duct epithelial cells
Loss of CFTR function in the pancreatic duct leads to dysregulated luminal pH causing premature activation of digestive enzymes and tissue necrosis. Drastic alterations in pancreatic tissue architecture and cellular composition changes the microenvironment of the islets. Given that CFTR is expressed...
ORGANISM(S): Mustela putorius furo (European domestic ferret) (Mustela furo) 
2021-05-27 | PXD025126 | Pride
Pancreas Cystic fibrosis Cystic fibrosis related diabetes Ductal cells Proteome Secretome 
UnknownThe Secretome Profiling of a Pediatric Airway Epithelium Infected with hRSV Identified Aberrant Apical/Basolateral Trafficking and Novel Immune Modulating (CXCL6, CXCL16, CSF3) and Antiviral (CEACAM1) Proteins.
Not available
S-EPMC7196588 | biostudies-literature
ProteomicsProteome analysis of adipose-derived stem cells cultured under clinically relevant conditions in a wound healing perspective
There is a large body of evidence supporting the beneficial role of adipose-derived stem cells (ASCs) in tissue repair and regeneration. These effects appear to be mainly mediated by paracrine signaling pathways and enhanced during hypoxia. Mass spectrometry (MS) represents a valuable tool for prote...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-04-01 | MSV000080858 | MassIVE
GenomicsThe human dental apical papilla promotes spinal cord repair through a paracrine mechanism
The human dental apical papilla promotes spinal cord repair through a paracrine mechanism
PRJNA789866 | ENA
UnknownQuantitative proteomics reveals an altered cystic fibrosis in vitro bronchial epithelial secretome.
Not available
S-EPMC4566109 | biostudies-literature
UnknownMolecular spectrum of secretome regulates the relative hepatogenic potential of mesenchymal stem cells from bone marrow and dental tissue.
Not available
S-EPMC5678086 | biostudies-literature
UnknownThe human dental apical papilla promotes spinal cord repair through a paracrine mechanism.
Not available
S-EPMC11072347 | biostudies-literature
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