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TranscriptomicsTranscription profiling of human HeLa cells follwing siRNA mediated knock down of the arginine methyltransferases CARM1 and/or PRMT1
siRNA mediated knockdown of the arginine methyltransferases CARM1 and/or PRMT1 in HeLa cells
ORGANISM(S): Homo sapiens 
2007-08-30 | E-MEXP-1173 | biostudies-arrayexpress
ProteomicsHuman Arginine Methylome
Identification of arginine methylation sites in human HEK293 cells, yielding a total of >8.000 high-confident modification sites on >3.300 proteins
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080836 | MassIVE
MetabolomicsThe ULK3 kinase is a key determinant of keratinocyte self-renewal and tumorigenesis targeting the arginine methylome
Epigenetic mechanisms oversee epidermal homeostasis and oncogenesis. The identification of kinases controlling these processes has direct therapeutic implications. We show that ULK3 is a nuclear kinase with elevated expression levels in squamous cell carcinomas (SCCs) arising in multiple body sites,...
2022-11-14 | MTBLS5155 | MetaboLights
ProteomicsMS-based arginine monomethylation study in Jurkat PRMT7 KO cells
Effects of Prmt7 genetic deletion to arginine monomethylation in Jurkat T-ALL cell line. Analysis was made using two different Prmt7 KO and one control cell lines.
ORGANISM(S): Homo Sapiens (human) 
2022-03-28 | PXD032819 | JPOST Repository
TranscriptomicsSuv4-20h Histone Methyltransferases Promote Neuroectodermal Differentiation by Silencing the Pluripotency-Associated Oct-25 Gene
Post-translational modifications (PTMs) of histones exert fundamental roles in regulating gene expression. During development, groups of PTMs are constrained by unknown mechanisms into combinatorial patterns, which facilitate transitions from uncommitted embryonic cells into differentiated somatic c...
ORGANISM(S): Xenopus laevis 
2013-02-06 | E-GEOD-41256 | biostudies-arrayexpress
ProteomicsLeishmania braziliensis Protein Arginine Methyltransferases interactomes
We functionally characterized the five predicted PRMTs in Leishmania braziliensis by gene knockout and endogenous protein HA tagging using CRISPR/Cas9 gene editing. We report that R-methylation profiles vary among Leishmania species and across L. braziliensis lifecycle stages, with the peak PRMT exp...
ORGANISM(S): Leishmania braziliensis 
2022-03-03 | PXD031057 | Pride
Leishmania braziliensis Prmt Protein arginine methyltransferase Gene knockout Crispr/cas9 
ProteomicsTrypanosome ZFP3 arginine residues are subject to modification by multiple methyltransferases and essential for transcriptome regulation
The overall goal of this study was to identify methylated arginine residues on the Trypanosoma brucei RNA binding protein, ZFP3, and determine their functions in transcriptome regulation. We expressed Ty-tagged ZFP3 in procyclic form T. brucei, immunoprecipitated triplicate samples with anti-Ty anti...
ORGANISM(S): Trypanosoma brucei 
2021-05-25 | PXD025153 | Pride
Zfp3 Arginine methylation Trypanosoma brucei Methyltransferases 
TranscriptomicsGenome-wide analysis of the prmt5 and prmt4a;4b mutant transcriptomes
The goal of this study was to compare the transcriptional profile (RNA-seq) of prmt5 and prmt4a;4b Arabidopsis mutants with their respective wild type plants grown under continous light conditions WT, prmt5 and prmt4a;4b mutant plants were grown together with their respective wild type plants for tw...
ORGANISM(S): Arabidopsis thaliana 
2015-04-03 | E-GEOD-62024 | biostudies-arrayexpress
ProteomicsSzewczyk_InhibitionOfPRMT7_P36_2020
This dataset consists of 16 raw MS files, acquired on Orbitrap Fusion Lumos Tribrid mass spectrometer operated in Data Dependent Acquisition (DDA) mode for the 8 input files and DDA with simultaneous parallel reaction monitoring (targeted masses; 599.33, 604.33, 608.23, 606.33, 407.89, 403.22, 651.3...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-01-08 | MSV000084773 | MassIVE
ProteomicsChanges in protein arginine methylation by GSK3368712
Type I Protein Arginine Methyltransferases (PRMTs) catalyze asymmetric dimethylation of arginine residues on numerous proteins. Type I PRMTs and their substrates have been implicated in human cancers, suggesting that inhibiting Type I PRMT activity offers a tractable approach for therapeutic interve...
ORGANISM(S): Homo sapiens (Human) 
2019-09-10 | PXD012747 | Pride
Lc-msms Human Arginine methyltransferases Cancer cell lines Immunoproteomic Antibody Type i prmt Methylscan 
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