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MetabolomicsInsights into the stereochemical mechanism of the B12-dependent radical SAM glutamine C- methyltransferases QCMT
Methyl-coenzyme M reductase (MCR) is a crucial enzyme for methanogenesis and harbors several unusual post-translational modifications. Recent studies have identified glutamine C-methyltransferase (QCMT), as a B12-dependent radical SAM enzyme responsible for methylating a glutamine residue within the...
2026-04-28 | MTBLS14287 | MetaboLights
TranscriptomicsSuv4-20h Histone Methyltransferases Promote Neuroectodermal Differentiation by Silencing the Pluripotency-Associated Oct-25 Gene
Post-translational modifications (PTMs) of histones exert fundamental roles in regulating gene expression. During development, groups of PTMs are constrained by unknown mechanisms into combinatorial patterns, which facilitate transitions from uncommitted embryonic cells into differentiated somatic c...
ORGANISM(S): Xenopus laevis 
2013-02-06 | E-GEOD-41256 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human HeLa cells follwing siRNA mediated knock down of the arginine methyltransferases CARM1 and/or PRMT1
siRNA mediated knockdown of the arginine methyltransferases CARM1 and/or PRMT1 in HeLa cells
ORGANISM(S): Homo sapiens 
2007-08-30 | E-MEXP-1173 | biostudies-arrayexpress
GenomicsGenomic profiling of DNA methyltransferases reveals a role for DNMT3B in genic methylation
This SuperSeries is composed of the SubSeries listed below. DNA methylation is an epigenetic modification associated with transcriptional repression of promoters and is essential for mammalian development. Establishment of DNA methylation is mediated by the de novo DNA methyltransferases DNMT3A and...
ORGANISM(S): Mus musculus 
2015-01-22 | E-GEOD-57413 | biostudies-arrayexpress
GenomicsGenomic profiling of DNA methyltransferases reveals a role for DNMT3B in genic methylation
DNA methylation is an epigenetic modification associated with transcriptional repression of promoters and is essential for mammalian development. Establishment of DNA methylation is mediated by the de novo DNA methyltransferases DNMT3A and DNMT3B, whereas DNMT1 ensures maintenance of methylation thr...
ORGANISM(S): Mus musculus 
2015-01-20 | E-GEOD-57411 | biostudies-arrayexpress
GenomicsGenomic profiling of DNA methyltransferases reveals a role for DNMT3B in genic methylation
DNA methylation is an epigenetic modification associated with transcriptional repression of promoters and is essential for mammalian development. Establishment of DNA methylation is mediated by the de novo DNA methyltransferases DNMT3A and DNMT3B, whereas DNMT1 ensures maintenance of methylation thr...
ORGANISM(S): Mus musculus 
2015-01-20 | E-GEOD-57412 | biostudies-arrayexpress
TranscriptomicsCharacterisation of two in vivo expressed methyltransferases of the Mycobacterium tuberculosis complex: antigenicity and genetic regulation
Genome sequencing of Mycobacterium tuberculosis complex members has accelerated the search for new disease control tools. Antigen mining is one area that has benefited enormously from access to genome data. Here genes that were identified by transcriptome analysis as upregulated in response to an in...
ORGANISM(S): Mycobacterium tuberculosis 
2008-01-09 | E-BUGS-59 | biostudies-arrayexpress
ProteomicsComparative proteomic analysis for proteins regulated by overexpression of two DNA methyltransferases in Xanthomonas campestris pv. vesicatoria strain 85-10.
- Identification of proteins whose abundance was altered by two DNA methyltransferases (XvDMT1 and XvDMT2) in Xanthomonas campestris pv. vesicatoria strain 85-10. - Shotgun proteomic analysis was used - Three strains were used with three biological replicates (total 9 samples). W+V: the wild-type s...
ORGANISM(S): Xanthomonas campestris pv. vesicatoria str. 85-10 
2021-03-23 | PXD019554 | Pride
Lc-ms/ms Dna methyltransferases Xanthomonas campestris pv. vesicatoria 
ProteomicsNovel N-terminal and lysine methyltransferases that target translation elongation factor 1A in yeast and human
Eukaryotic elongation factor 1A (eEF1A) is an essential, highly methylated protein that facilitates translational elongation by delivering aminoacyl-tRNAs to ribosomes. Here we report a new eukaryotic protein N-terminal methyltransferase, Saccharomyces cerevisiae YLR285W, which methylates eEF1A at a...
ORGANISM(S): Homo sapiens (Human) Saccharomyces cerevisiae (Baker's yeast) 
2015-11-10 | PXD002941 | Pride
Post-translational modifications N-terminus Lysine Methylation Methyltransferases 
ProteomicsProfiling proteins regulated by putative methyltransferases in Xanthomonas axonopodis pv. glycines str. 8ra
- Identification of proteins whose expression was affected by three putative methyltransferases in Xanthomonas axonopodis pv. glycines str. 8ra - Shotgun proteomic analysis was used - Four strains were used with three biological replicates (total 12 samples). One is the wildtype carrying an empty ve...
ORGANISM(S): Xanthomonas axonopodis pv. glycines str. 8ra 
2019-11-11 | PXD012590 | Pride
Xanthomonas axonopodis pv. glycines Label-free shotgun proteomics Methyltransferase 
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