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ProteomicsStage-specific proteomes from Onchocerca ochengi, sister species of the human river blindness parasite, uncovers adaptations to a nodular lifestyle
In spite of 40 years of control efforts, onchocerciasis (river blindness) remains one of the most important neglected tropical diseases, with 17 million people affected. The aetiological agent, Onchocerca volvulus, is a filarial nematode with a complex lifecycle involving several distinct stages in ...
ORGANISM(S): Onchocerca ochengi (Filarial nematode worm) 
2016-05-31 | PXD002889 | Pride
Lc-msms River blindness Onchocerca ochengi 
ProteomicsCharacterisation of a novel glycosylated glutathione transferase of Onchocerca ochengi, closest relative of the human river blindness parasite
Filarial nematodes possess glutathione transferases (GSTs), ubiquitous enzymes with potential to detoxify xenobiotic and endogenous substrates, and modulate the host immune system, which may aid worm infection establishment, maintenance and survival in the host. Here we have identified and character...
ORGANISM(S): Onchocerca ochengi (Filarial nematode worm) 
2020-05-26 | PXD013440 | Pride
Glycosylation Onchocerca Prostaglandin synthase Detoxification Glycans Immune modulation Gsts 
ProteomicsProteomic profiling of enteroid cultures skewed towards development of specific epithelial lineages
Recently, three-dimensional small intestinal organoids (enteroids) have been developed from cultures of intestinal stem cells which differentiate in vitro to generate all the differentiated epithelial cell types associated with the intestine and mimic the structural properties of the intestine obser...
ORGANISM(S): Mus musculus (Mouse) 
2019-01-11 | PXD005006 | Pride
Differentiation  mass spectrometry  gastrointestinal system  stem cells 
ProteomicsDissecting the molecular diversity and commonality of bovine and human treponemes identifies key survival and adhesion mechanisms
Here, we report the first complete genomes of three cultivable treponeme species from bovine digital dermatitis (DD) skin lesions, two comparative human treponemes and a bovine gastrointestinal (GI) isolate. Key genomic differences between bovine and human treponemes implicate microbial mechanisms t...
ORGANISM(S): Treponema sp. T19 Treponema pedis Treponema ruminis Treponema phagedenis Treponema medium Treponema sp. T320A 
2021-03-16 | PXD022419 | Pride
Bovine digital dermatitis Treponemes Shotgun lc msms 
ProteomicsEvolutionary trade-offs associated with loss of PmrB function in host-adapted Pseudomonas aeruginosa
Pseudomonas aeruginosa colonises the upper airway of cystic fibrosis (CF) patients, providing a reservoir of host-adapted genotypes that subsequently establish chronic lung infection. We previously experimentally-evolved P. aeruginosa in a murine model of respiratory tract infection and observed mut...
ORGANISM(S): Pseudomonas aeruginosa 
2018-07-11 | PXD009705 | Pride
Label free quantification Pseudomonas aeruginosa Pmrb 
ProteomicsComparative analysis of the secretome from a model filarial nematode (Litomosoides sigmodontis) reveals maximal diversity in gravid female parasites
Filarial nematodes (superfamily Filarioidea) are responsible for an annual global health burden of approximately 6.3 million disability-adjusted life-years, which represents the greatest single component of morbidity attributable to helminths affecting humans. No vaccine exists for the major filaria...
ORGANISM(S): Litomosoides sigmodontis (Filarial nematode worm) 
2014-07-22 | PXD000756 | Pride
Filarial nematode Excretory-secretory products Lc-ms/ms Litomosoides sigmodontis 
ProteomicsDetermination of the interactome of Non-Structural Protein12 from Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus with Host Cellular Proteins UsingHigh Throughput Proteomics and Identification of Hsp70 as a Critical Cellular Factor for Virus Biology
Porcine reproductive and respiratory syndrome virus (PRRSV) has caused tremendous economic losses and continues to be a serious problem to the swine industry worldwide. Although extensive research has been focused on PRRSV, the structure and function of some viral proteins like nonstructural protein...
ORGANISM(S): Homo sapiens (Human) 
2016-06-27 | PXD004003 | Pride
Label free proteomics Hp-prrsv Nsp12 Hsp70 Inhibitor study Interactome 
UnknownCardiac arrest in seronegative idiopathic inflammatory myopathy: a case report.
Not available
S-EPMC10903167 | biostudies-literature
ProteomicsMacaque models for influenza A virus
Non-human primates are the animals closest to humans for use in influenza A virus challenge studies, in terms of their phylogenetic relatedness, physiology and immune systems. Previous studies have shown that cynomolgus macaques (Macaca fascicularis) are permissive for infection with H1N1pdm influen...
ORGANISM(S): Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) Unidentified Influenza A virus (H1N1) 
2016-06-20 | PXD003803 | Pride
Label free proteomics H1n1pdm influenza virus Intra-nasal challenge 
UnknownACTB Loss-of-Function Mutations Result in a Pleiotropic Developmental Disorder.
Not available
S-EPMC5812896 | biostudies-literature
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