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TranscriptomicsTranscription profiling by array of human B cells from patients with chronic lymphocytic leukemia after co-culture with nurse-like cells
In the marrow and lymphatic tissues, chronic lymphocytic leukemia (CLL) cells interact with accessory cells that constitute the leukemia microenvironment. In lymphatic tissues, CLL cells are interspersed with CD68+ nurselike cells (NLC) and T cells. However, the mechanism regulating co-localization ...
ORGANISM(S): Homo sapiens 
2009-01-13 | E-GEOD-13811 | biostudies-arrayexpress
TranscriptomicsEffect of amphotericin B on Aspergillus fumigatus
Amphotericin B (AMB) is the most widely used polyene antifungal drug for the treatment of systemic fungal infections including invasive aspergillosis. We aimed to understand molecular targets of AMB in Aspergillus fumigatus (Afu) by genomic approaches. Amphotericin B (AMB) is the most widely used p...
ORGANISM(S): Aspergillus fumigatus 
2010-05-26 | E-GEOD-10505 | biostudies-arrayexpress
ProteomicsADAR1-mediated RNA editing promotes B cell lymphomagenesis.
The project aims to evaluate the contribution of ADAR1 RNA editing to B cell lymphomagenesis, specifically in diffuse large B cell lymphoma (DLBCL). Within our DLBCL cohort, RNA editing targets transcripts within known lymphoma-driving pathways such as apoptosis, p53 and NF-kB signaling, as well as ...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD041549 | Pride
Adar1 Mavs Rck8 Dlbcl 
TranscriptomicsUV-B-induced gene expression changes in Chlamydomonas reinhardtii
We analysed global gene expression changes in Chlamydomonas reinhardtii in response to 1h UV-B, applied at the same low level that was seen to promote subsequent UV-B stress tolerance, in order to elucidate the transcriptional reprogramming that leads to UV-B acclimation. mRNA profiles generated by ...
ORGANISM(S): Chlamydomonas reinhardtii 
2015-11-11 | E-GEOD-68739 | biostudies-arrayexpress
UnknownResistance of young gelatinase B-deficient mice to experimental autoimmune encephalomyelitis and necrotizing tail lesions.
Not available
S-EPMC409857 | biostudies-literature
TranscriptomicsEBV Modulates Host Cell microRNA-194 to Promote IL-10 Production and B Lymphoma Cell Survival
The purpose of this study was to investigate the effect of EBV infection on host cell miR and to characterize the miRNome in EBV+ B cell lymphomas from patients with PTLD. A qPCR array was used to measure the expression level of 377 previously identified miRs from RNA isolated from three sources: to...
ORGANISM(S): Homo sapiens 
2014-09-10 | E-GEOD-61283 | biostudies-arrayexpress
TranscriptomicsTranscriptional Corepressors HIPK1 and HIPK2 Control Angiogenesis via TGF-b-TAK1-depdendent Mechanism
Transforming growth factor-b (TGF-b) regulates various aspects of vascular development, yet the signaling mechanisms of TGF-b in the control of angiogenesis remain poorly characterized. Here we show that homeodomain interacting protein kinases, HIPK1 and HIPK2, are transcriptional corepressors that ...
ORGANISM(S): Mus musculus 
2013-06-01 | E-GEOD-39253 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Arabidopsis exposed to UV-B stress - AtGenExpress
AtGenExpress: A multinational coordinated effort to uncover the transcriptome of the multicellular model organism Arabidopsis thaliana. The activity of genes and their encoded products can be regulated in several ways, but transcription is the primary level, since all other modes of regulation (RNA ...
ORGANISM(S): Arabidopsis thaliana 
2008-06-13 | E-GEOD-5626 | biostudies-arrayexpress
TranscriptomicsB-type lamins differentially associate with specific genes during differentiation without directly affecting their expression
B-type lamins, the major structural component of the nuclear lamina, is thought to play a repressive role in the expression of many of its bound genes whose silencing are known to be critical for cell differentiation during early development. Using global mapping of lamin-B-chromatin interaction, w...
ORGANISM(S): Mus musculus 
2011-10-31 | E-GEOD-24532 | biostudies-arrayexpress
UnknownATG5 is required for B cell polarization and presentation of particulate antigens.
Not available
S-EPMC6333460 | biostudies-literature
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