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ProteomicsProteolytic processing of CD99
The adhesion molecule CD99 is essential for transendothelial migration (TEM) of leukocytes. Here we demonstrate by biochemical and cellular assays that CD99 undergoes ectodomain shedding by the metalloprotease meprin ? and subsequent intramembrane proteolysis by ?-secretase. The cleavage site in CD9...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080746 | MassIVE
ProteomicsCell surface processing of CD109 by meprin β leads to the release of soluble fragments and reduced expression on extracellular vesicles
Cluster of differentiation 109 (CD109) is a glycosylphosphatidylinositol (GPI) anchored protein expressed on primitive hematopoietic stem cells, activated platelets, CD4+ and CD8+ T-cells and keratinocytes. In recent years CD109 was also associated with different tumor entities and identified as a p...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2021-01-28 | PXD023727 | Pride
Cd109  macroglobulin  meprin β  exosomes  extracellular vesicles  tem  tep1r 
UnknownFinancial toxicity in cancer patients treated with radiotherapy in Germany-a cross-sectional study.
Not available
S-EPMC9700565 | biostudies-literature
UnknownFactors associated with reduction in quality of life after SARS-CoV-2 infection.
Not available
S-EPMC11861590 | biostudies-literature
GenomicsRapid High-Resolution Functional Mapping of Yeast Genomes by Saturated Transposition
The yeast Saccharomyces cerevisiae is a highly powerful model for systems genetics. While the advent of ordered deletion libraries has considerably facilitated yeast screening, it has also narrowed the diversity of screenable variants and precluded the exploration of the non-coding genome. Here, we ...
ORGANISM(S): Saccharomyces cerevisiae 
2017-05-11 | E-MTAB-4885 | biostudies-arrayexpress
UnknownNovel endoscopic scoring system for immune mediated colitis: a multicenter retrospective study of 674 patients.
Not available
S-EPMC11832009 | biostudies-literature
TranscriptomicsAcetyl-CoA metabolism by ACSS2 regulates neuronal histone acetylation and long-term memory [RNA-seq]
Metabolic production of acetyl-CoA has been linked to histone acetylation and gene regulation, however the mechanisms are largely unknown. We show that the metabolic enzyme acetyl-CoA synthetase 2 (ACSS2) is a critical and direct regulator of histone acetylation in neurons and of long-term mammalian...
ORGANISM(S): Mus musculus 
2017-05-01 | E-GEOD-76853 | biostudies-arrayexpress
GenomicsAcetyl-CoA metabolism by ACSS2 regulates neuronal histone acetylation and long-term memory [ChIP-seq]
Metabolic production of acetyl-CoA has been linked to histone acetylation and gene regulation, however the mechanisms are largely unknown. We show that the metabolic enzyme acetyl-CoA synthetase 2 (ACSS2) is a critical and directchum regulator of histone acetylation in neurons and of long-term mamma...
ORGANISM(S): Mus musculus 
2017-05-01 | E-GEOD-76850 | biostudies-arrayexpress
ProteomicsCommensal Clostridiales strains mediate effective anti-cancer immune response against solid tumors
We identified certain members of the gut microbiota associated with a lower tumor burden in mouse models of colorectal cancer (CRC). Orally applied, a mix of four Clostridiales strains (CC4) prevented and even successfully treated CRC as a stand-alone therapy.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2021-06-15 | MSV000087624 | MassIVE
UnknownEGFL7 enhances surface expression of integrin ?
Not available
S-SCDT-EMM-2017-08420 | biostudies-other
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