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UnknownExploration and pharmacokinetic profiling of phenylalanine based carbamates as novel substance p 1-7 analogues.
Not available
S-EPMC4265825 | biostudies-literature
UnknownIntracellular drug bioavailability: a new predictor of system dependent drug disposition.
Not available
S-EPMC5320532 | biostudies-literature
UnknownGlobal Proteome Changes in Liver Tissue 6 Weeks after FOLFOX Treatment of Colorectal Cancer Liver Metastases.
Not available
S-EPMC5260963 | biostudies-literature
UnknownCadmium Transport in a Model of Neonatal Intestinal Cells Correlates to MRP1 and Not DMT1 or FPN1.
Not available
S-EPMC3658413 | biostudies-literature
ProteomicsHuman liver homogenate, liver microsomes, low-speed centrifugation pellet and hepatocytes LC-MS/MS from 15 matched donors
LC-MS/MS-based label-free proteomics of human liver homogenate, human liver microsomes, and human hepatocytes from 15 matched donors used to compare and understand differences in two major in vitro systems used for drug metabolism studies
ORGANISM(S): Homo sapiens (Human) 
2021-03-29 | PXD014131 | Pride
Human Low-speed centrifugation pellet Hepatocytes Liver Liver microsomes Lc-ms/ms 
ProteomicsLiver zonation patterns and cell size variability in isolated human hepatocytes
Human hepatocytes differ in gene expression and function across the hexagonal lobules of the tissue microarchitecture, a phenomenon referred to as liver zonation. Hepatocytes also display intra-lobular differences in cell size, but to what extent zonal expression and function correlate with cell siz...
ORGANISM(S): Homo sapiens (Human) 
2021-01-26 | PXD013142 | Pride
Human Hepatocytes Cell size variability Liver Zonation 
UnknownImproved predictions of time-dependent drug-drug interactions by determination of cytosolic drug concentrations.
Not available
S-EPMC6458156 | biostudies-literature
ProteomicsConditions for maintenance of hepatocyte differentiation and function in 3D cultures
3D spheroid cultures of primary human hepatocytes (PHH) are used in studies of hepatic drug metabolism and toxicity. However, the 3D spheroids are maintained under different conditions, with possible cofounding results. Here we performed an in-depth analysis of how various culture conditions influen...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD024632 | Pride
Primary human hepatocyte culture Lc-ms/ms 
ProteomicsIlluminating the Function of the Orphan Transporter, SLC22A10 in Humans and Other Primates
HEK293 Flp-In cells were transfected transiently with various SLC22A10 orthologs, including human, chimpanzee, and the mutations to proline or leucine at position 220. After 72 hours of transfection, cell pellets were collected. The quantification was performed on both HEK293 cells and HEK293cells e...
ORGANISM(S): Homo sapiens (Human) 
2024-04-09 | PXD047102 | Pride
Hek293 Slc22a10 Lc-ms/ms 
ProteomicsThe intracellular free concentration of EDCs enables successful translation between cell-free and cell-based estrogenic activity assays
Many environmental toxicants can activate the estrogen receptor α (ERα), contributing to disruption of normal endocrine function. Although these activities are known from in silico, in vitro and in vivo models, transferring the active concentrations between the different models is often challenging....
ORGANISM(S): Homo sapiens (Human) 
2025-07-31 | PXD059544 | Pride
In vitro Endocrine-disrupting chemicals Estrogenic chemicals Intracellular free concentration 
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