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ProteomicsSites of aspirin-mediated lysine acetylation in HeLa cells, part 2
Aspirin, or acetylsalicylic acid is widely used to control pain, inflammation and fever. Important to this function is its ability to irreversibly acetylate cyclooxygenases at active site serines. Aspirin has the potential to acetylate other amino-acid side-chains, leading to speculation that aspiri...
ORGANISM(S): Homo sapiens (Human) 
2016-12-24 | PXD004995 | Pride
Lysine acetylation Aspirin Hela 
ProteomicsSites of aspirin-mediated lysine acetylation in HeLa cells
Aspirin, or acetylsalicylic acid is widely used to control pain, inflammation and fever. Important to this function is its ability to irreversibly acetylate cyclooxygenases at active site serines. Aspirin has the potential to acetylate other amino-acid side-chains, leading to speculation that aspiri...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080778 | MassIVE
ProteomicsSites of aspirin-mediated lysine acetylation in HeLa cells, part 2
Aspirin, or acetylsalicylic acid is widely used to control pain, inflammation and fever. Important to this function is its ability to irreversibly acetylate cyclooxygenases at active site serines. Aspirin has the potential to acetylate other amino-acid side-chains, leading to speculation that aspiri...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080852 | MassIVE
ProteomicsSites of aspirin-mediated lysine acetylation in HeLa cells
Aspirin, or acetylsalicylic acid is widely used to control pain, inflammation and fever. Important to this function is its ability to irreversibly acetylate cyclooxygenases at active site serines. Aspirin has the potential to acetylate other amino-acid side-chains, leading to speculation that aspiri...
ORGANISM(S): Homo sapiens (Human) 
2017-01-10 | PXD003530 | Pride
Lysine acetylation Aspirin Hela 
ProteomicsHalf-lives of aspirin-mediated lysine acetylations
Aspirin, or acetylsalicylic acid is widely used to control pain, inflammation and fever. An important property of aspirin is its ability to acetylate multiple cellular proteins with some pharmacological functions explicable by the irreversible acetylation of cyclooxygenases at active site serine res...
ORGANISM(S): Homo sapiens (Human) 
2019-03-05 | PXD003655 | Pride
Aspirin Acetylation Lysine 
ProteomicsHuman Platelets PRM - A high glucose level is associated with decreased aspirin-mediated acetylation of platelet cyclooxygenase (COX)-1 at serine 529: A pilot study
The main aim of this study is to decipher the mutual impact that high glucose levels and diabetes have on aspirin-mediated acetylation of COX-1 through a targeted parallel reaction monitoring MS approach.
ORGANISM(S): Homo sapiens (Human) 
2018-10-10 | PXD011204 | Pride
Human Prm Diabetes Aspirin-acetylation Platelets 
ProteomicsHuman platelet proteome LC-MS/MS
This study aims to elucidate the extent of ex-vivo aspirin-induced acetylation on human platelet proteome from poorly controlled diabetic patients through a shotgun proteomic approach.
ORGANISM(S): Homo sapiens (Human) 
2018-12-19 | PXD011582 | Pride
Human Platelets Aspirin-mediated acetylation 
UnknownBeclin 1 acetylation impairs the anticancer effect of aspirin in colorectal cancer cells.
Not available
S-EPMC5650378 | biostudies-literature
UnknownAspirin-Mediated Acetylation of SIRT1 Maintains Intestinal Immune Homeostasis.
Not available
S-EPMC11109641 | biostudies-literature
ProteomicsAspirin reshapes acetylomes in inflammatory and cancer cells via CoA-dependent and –independent pathways
We used a deuterium-labeled aspirin (D-aspirin) together with mass spectrometry-based acetylomic analysis, termed “DAcMS”, to investigate the landscape of protein acetylation induced by aspirin. And we further demonstrated that aspirin acetylates proteins through both acetyl-CoA-dependent and -indep...
ORGANISM(S): Homo Sapiens Mus Musculus 
2020-01-21 | PXD017220 |
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