Astrocyte activation

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Organisms

Mus musculus (229)
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Organisms

Mus musculus (132)
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Mus (2)
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Repository

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geo (198)
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Tissue

Brain (21)
Astrocyte (13)
Cell culture (12)
Microglial cell (6)
Neuron (3)
Permanent cell line cell (3)
Astrocyte of the cerebral cortex (2)
Cerebrospinal fluid (2)
Mature astrocyte (2)
Blood plasma (2)
Astrocyte of the forebrain (1)
Spinal cord motor neuron (1)
Immature microglial cell (1)
Ganglionic layer of retina (1)
Brain microvascular endothelial cell (1)
Primary cerebral cortical neuronï¿½ (1)
Neuron of cerebral cortex (1)
Glutamatergic neuron (1)
Retina (1)
Cerebral cortex neuron (1)
Cerebral cortex endothelial cell (1)
Kidney epithelial cell (1)
Stem cell (1)
Primary cell (1)
Epithelial cell (1)
Kidney (1)
Blood cell (1)
Blood (1)

Disease

Alzheimer's disease (3)
Amyotrophic lateral sclerosis (3)
Glaucoma (2)
HIV-associated dementia (1)
Normal (1)
Bacterial meningitis (1)
Relapsing-remitting multiple sclerosis (1)
Multiple sclerosis (1)
Neurodegenerative disease (1)
Brain glioblastoma multiforme (1)
Huntington Disease (1)
Brain cancer (1)
Glioblastoma (1)
Trypanosomiasis (1)

Technology Type

Mass Spectrometry (40)
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Bottom-up proteomics (13)
Gel-based experiment (6)
Data-dependent acquisition (6)
Mass spectrometry (4)
SWATH MS (4)
Data-independent acquisition (4)
Affinity purification coupled with mass spectrometry proteomics (2)
Mass spectrometry assay (1)
SRM/MRM (1)
Top-down proteomics (1)

Instrument Platform

Illumina NovaSeq 6000 (5)
NextSeq 500 (4)
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Orbitrap Exploris 480 (3)
Illumina HiSeq 2000 (2)
TripleTOF 5600 (2)
Q Exactive (2)
Liquid Chromatography MS - positive - reverse phase (2)
Liquid Chromatography MS - negative - reverse phase (2)
Qubit 4.0 and TapeStation (1)
Element AVITI (1)
Not applicable (1)
Illumina NovaSeq X (1)
NextSeq 2000 (1)
NextSeq 550 (1)
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Q-Exactive (Thermo Fisher) (1)
Orbitrap Astral (1)
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TimsTOF Pro (1)
Q Exactive HF-X (1)
Gas Chromatography MS - positive (1)
Liquid Chromatography MS - positive (1)
Liquid Chromatography MS - alternating - reverse phase (1)
Liquid Chromatography MS - positive - reverse-phase (1)
Liquid Chromatography MS - negative - reverse-phase (1)

Publication Date

2026 (51)
2025 (51)
2012 (36)
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2024 (32)
2013 (24)
2010 (24)
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2022 (23)
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2011 (20)
2020 (17)
2016 (17)
2008 (16)
2018 (14)
2014 (13)
2009 (11)
2007 (11)
2017 (10)
2019 (9)
2006 (5)
2005 (1)

CHEBI ID

CHEBI:16765 (2)
CHEBI:28747 (2)
CHEBI:17697 (2)
CHEBI:10072 (2)
CHEBI:27823 (2)
CHEBI:18344 (2)
CHEBI:185598 (1)
CHEBI:188430 (1)
CHEBI:79785 (1)
CHEBI:190859 (1)
CHEBI:113547 (1)
CHEBI:60458 (1)
CHEBI:194565 (1)
CHEBI:63448 (1)
CHEBI:82120 (1)
CHEBI:143432 (1)
CHEBI:86598 (1)
CHEBI:7716 (1)
CHEBI:110184 (1)
CHEBI:193252 (1)
CHEBI:32144 (1)
CHEBI:194609 (1)
CHEBI:186665 (1)
CHEBI:185171 (1)
CHEBI:34875 (1)
CHEBI:17056 (1)
CHEBI:20408 (1)
CHEBI:81916 (1)
CHEBI:168748 (1)
CHEBI:36151 (1)

Metabolite Name

L-Tryptophan (3)
L-Tyrosine (3)
Erythrulose 1-phosphate (2)
4-Amino-2-hydroxylamino-6-nitrotoluene (2)
2-Pyrone-4,6-dicarboxylate (2)
D-myo-Inositol 1,4-bisphosphate (2)
Sevoflurane (2)
Nitroglycerin (2)
Coniferyl alcohol (2)
Hexafluoroisopropanol (2)
Oxidized glutathione (2)
Picolinic acid (2)
L-Lysine (2)
Tryptamine (2)
5-Hydroxyindoleacetic acid (2)
D-Erythrose 4-phosphate (2)
L-Histidine (2)
L-Glutamic acid (2)
Taurine (2)
Genipin (2)
2-Heptylbenzothiazole (2)
Tyramine (2)
Histamine (2)
Palmitic acid (2)
L-Glutamine (2)
Glycerol 3-phosphate (2)
Uric acid (2)
Hippuric acid (2)
Selenite ion (1)
2,5-dichloro-2,5-cyclohexadiene-1,4-diol (1)

First Public Date

2025 (57)
2026 (42)
2023 (29)
2024 (25)
2020 (22)
2022 (16)
2021 (15)
2014 (12)
2018 (9)
2019 (5)
2017 (5)
2015 (4)

Modification

4-tetrahydrothiazine-3-carboxylic acid (1)

Study type

Transcription profiling by array (151)
RNA-seq of coding RNA (19)
ChIP-seq (7)
Transcription profiling by RT-PCR (5)
Other (4)
Unknown experiment type (3)
Genotyping by array (3)
RNA-seq of coding RNA from single cells (2)
MicroRNA profiling by high-throughput sequencing (1)
ChIP-chip by tiling array (1)
Comparative genomic hybridization by array (1)
Proteomic profiling by array (1)
RNA-seq of total RNA (1)

Release Date

2022 (191)
2025 (189)
2023 (159)
2021 (146)
2024 (135)
2020 (109)
2018 (98)
2019 (96)
2016 (70)
2017 (62)
2012 (62)
2015 (61)
2013 (52)
2014 (46)
2011 (44)
2026 (37)
2010 (30)
2008 (25)
2009 (22)
2007 (15)
2006 (7)
2005 (6)
2004 (4)
2003 (1)
2002 (1)
1998 (1)

Lab affiliation

First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China (2)
DZNE Munich, Neuroproteomics, Feodor-Lynen-Str. 17, 81377 München, Germany (2)
Associate Professor, Department of Neurology, Yale University School of Medicine (1)
Roskamp Institute, Neurodegenerative Disease and Proteomics Lab, Sarasota, FL (1)
The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK Department of Neuromuscular Diseases, Queen Square Institute of Neurology, University College London, London, WC1N 3BG, UK (1)
Laboratory of Experimental Hematology, Vaccine and Infectious Disease Institute (Vaxinfectio), University of Antwerp, 2610 Wilrijk, Belgium (1)
Institute of Genetics and Developmental Biology, Chinese Acadamy of Sciences (1)
Neuron Glia Biology in Health and Disease Group, iMed.Ulisboa, Faculty of pharmacy, University of Lisbon, Lisbon, Portugal (1)
Department of Mitochondrial Biology, Max Planck Institute for Biology of Ageing, 50931 Cologne, Germany Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 77 Stockholm, Sweden Max Planck Institute Biology of Ageing - Karolinska Institutet Laboratory, Karolinska Institutet, Stockholm, Sweden. (1)
Laboratoire Protéomique, Réponse Inflammatoire et Spectrométrie de Masse (PRISM) Inserm U1192, Université de Lille Sciences et Technologies, Villeneuve d'Ascq, France. (1)
Guangdong Medical University (1)
1) Department of Analytical Chemistry and Biochemisty, AGH University of Krakow 2) Laboratory of Proteomics and Mass Spectrometry, Maj Institute of Pharmacology, Polish Academy of Sciences (1)
Room 6313, Academic building, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon (1)
University Magdeburg Institute of Exptl. Internal Medicine Leipziger STr. 44 39120 Magdeburg Germany (1)
Translational Biomarker Group, University of Geneva, Geneva, Switzerland (1)
Italian National Institute of Health (1)
Laboratory of neurobiology and pathology, Department of Cellular, Computational and Integrative Biology (DeCIBIO), University of Trento, Italy (1)
CRG, UPF (1)
Department of Pharmacology Director of Proteomics Mass Spectrometry Facility (1)
Motor Neuron Disease Research Centre, Macquarie University, NSW, 2113, Australia (1)
Department of Biochemistry and Molecular Biology University of Southern Denmark Campusvej 55 DK-5230 Odense M Denmark (1)
Department of Neurology, Yale University, New Haven, CT, USA (1)
Department Functional Proteomics Medizinisches Proteom-Center Ruhr-University Bochum Building ProDi Gesundheitscampus 4 44780 Bochum Germany (1)
Department of Pharmacology, Physiology & Neuroscience School of Medicine University of South Carolina Columbia, South Carolina, 29209 USA (1)
State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei, China (1)
Department of Parasitology, Faculty of Science, Charles University in Prague, Biocev, Vestec, Prague, Czech Republic (1)
1) Department of Analytical Chemistry and Biochemistry, AGH University of Krakow, Krakow, Poland 2) Laboratory of Proteomics and Mass Spectrometry, Maj Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland (1)
Spanish National Cancer Research Center (CNIO) (1)
Institute of Biochemistry II, Goethe University Frankfurt, Germany (1)
Professor Department of Biochemistry and Molecular Biology University of Southern Denmark Campusvej 55 DK-5230 Odense M Denmark (1)

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Effects of Hsp72 on astrocyte activation following stroke in the mouse

Astrogliosis is a hallmark of the response to brain ischemia, comprised of changes in gene expression and morphology. Hsp72 protects from cerebral ischemia, and although several mechanisms of protection have been investigated, effects on astrocyte activation are unknown. To identify potential mecha...

ORGANISM(S): Mus musculus

2013-01-11 | E-GEOD-28731 | biostudies-arrayexpress

Gut microflora alleviate immune response during E.coli-induced bladder cystits via AhR/MANF activation

In recent years, with the deepening of research on intestinal microbiota, we found intestinal microbiota plays an important role in host immune regulation and barrier maintenance through cross-talk between the microbiota and the host. New evidence suggests that disruption of the fragile balance w...

2023-07-11 | MTBLS5572 | MetaboLights

Astrocyte proteome from the rat substantia nigra. Study in animal model of fluorocitrate-induced astrocyte dysfunction and microglia activation.

Dysfunction of astrocytic support for prolonged time can be harmful for nervous system. Inflammation and glia activation are among hallmarks of most neurodegenerative diseases. Therefore, astrocytes are considered as druggable targets for disease modifying strategies. Partial lesion of dopaminergic ...

ORGANISM(S): Rattus norvegicus (Rat)

2026-02-11 | PXD067265 | Pride

Astrocyte Gi signaling activation in the striatum

PRJNA487960 | ENA

Microarray analysis of the astrocyte transcriptome in the ageing brain: relationship to Alzheimer's pathology and ApoE genotype

Astrocyte dysfunction impacts their normal function, including neuronal support, thereby contributing to neurodegenerative pathologies including Alzheimer's disease (AD). Therefore to understand the role of astrocytes in the pathogenesis of age-related disorders we analysed the gene expression profi...

ORGANISM(S): Homo sapiens

2011-06-01 | E-GEOD-29652 | biostudies-arrayexpress

Time-Restricted Feeding Orchestrates Astrocytic Metabolic Reprogramming via the Wnt Pathway to Alleviate Sevoflurane-Induced Neural Injury

Perioperative neurocognitive disorders (PND) pose a significant challenge for aging surgical patients, with sevoflurane anesthesia being an identified risk factor. Time-restricted feeding (TRF), a dietary regimen, shows promise in mitigating age-related cognitive decline, but its efficacy and mec...

2026-02-17 | MTBLS13891 | MetaboLights

Corticosterone regulation of mRNAs and and corresponding RU486 antagonism in astrocytes in vitro

Analysis of mRNA gene expression changes mediated by natural glucocorticoid ligand corticosterone in mouse cortical primary astrocyte cultures; also, parallel analysis of RU486 (mifepristone) antagonism of corticosterone-mediated mRNA changes. Total RNA obtained from astrocyte cultures subjected to ...

ORGANISM(S): Mus musculus

2013-01-09 | E-GEOD-39270 | biostudies-arrayexpress

Astrocyte elevated gene-1 (AEG-1) and c-Myc cooperate to promote hepatocarcinogenesis

Double transgenic mice with hepatocyte-specific expression of AEG-1 and c-Myc show aggressive HCC compared to single transgenics. Gene expression was analyzed to understand the molecular mechanism by which AEG-1 and c-Myc cooperate to promote hepatocarcinogenesis. Livers were collected from naïve ad...

ORGANISM(S): Mus musculus

2014-09-30 | E-GEOD-61875 | biostudies-arrayexpress

Transcription profiling of rat astrocytes treated with epidermal growth factor (EGF)

Primary cultures of astrocytes from rat optic nerve heads were treated with EGFR ligand, EGF. Two cell lines from two different rat donors were used. The sister cell cultures were set as control and EGF treated groups. Experiment Overall Design: experiment #1: compared control astrocyte cultures to ...

ORGANISM(S): Rattus norvegicus

2007-11-29 | E-GEOD-5282 | biostudies-arrayexpress

Alcohol Dependence-Induced Astrocyte Immune Activation in the Nucleus Accumbens

PRJNA1333313 | ENA

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