Fluorocitrate - OmicsDI

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1) Department of Analytical Chemistry and Biochemistry, AGH University of Krakow, Krakow, Poland 2) Laboratory of Proteomics and Mass Spectrometry, Maj Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland (1)
1) Department of Analytical Chemistry and Biochemisty, AGH University of Krakow 2) Laboratory of Proteomics and Mass Spectrometry, Maj Institute of Pharmacology, Polish Academy of Sciences (1)

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Microglia proteome from the rat substantia nigra. Study in animal model of fluorocitrate-induced astrocyte dysfunction and microglia activation.

Nervous system inflammation and microglia activation are among hallmarks of Parkinson’s disease. Partial nigrostriatal neurodegeneration can be compensated. Interaction between neurons, microglia and astrocytes could be essential for this functional adaptation and neuronal survival in long-term, but...

ORGANISM(S): Rattus norvegicus (Rat)

2026-02-11 | PXD066353 | Pride

Astrocyte proteome from the rat substantia nigra. Study in animal model of fluorocitrate-induced astrocyte dysfunction and microglia activation.

Dysfunction of astrocytic support for prolonged time can be harmful for nervous system. Inflammation and glia activation are among hallmarks of most neurodegenerative diseases. Therefore, astrocytes are considered as druggable targets for disease modifying strategies. Partial lesion of dopaminergic ...

ORGANISM(S): Rattus norvegicus (Rat)

2026-02-11 | PXD067265 | Pride

Proteomics Lc-ms Fluorocitrate Astrocyte Substantia nigra

The reaction of fluorocitrate with aconitase and the crystal structure of the enzyme-inhibitor complex.

Not available

S-EPMC19395 | biostudies-literature

Sodium fluorocitrate having protective effect on palmitate-induced beta cell death improves hyperglycemia in diabetic db/db mice.

Not available

S-EPMC5635019 | biostudies-literature

Sodium fluorocitrate having inhibitory effect on fatty acid uptake ameliorates high fat diet-induced non-alcoholic fatty liver disease in C57BL/6J mice.

Not available

S-EPMC6882787 | biostudies-literature