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TranscriptomicsHEK293 stably expressing Autoimmune regulator protein
Auto Immune REgulator (AIRE) protein expression in HEK293 cells Three cell-lines where used in the study: HEK293-NC; control cell-line expressing yellow fluorescent protein (YFP) HEK-AIRE1, HEK-AIRE2; two different clone-derived Autoimmune regulator protein expressing cell-lines HEK-AIRE-D312A; c...
ORGANISM(S): Homo sapiens 
2010-05-05 | E-GEOD-16877 | biostudies-arrayexpress
ProteomicsProteome profiling of GC1-spg cells over-expressing Autoimmune Regulator (AIRE)
This project was aimed at evaluating the influence of Autoimmune Regulator in gene expression in GC1-spg cells.
ORGANISM(S): Mus musculus (Mouse) 
2016-06-14 | PXD002511 | Pride
Testis Spermatogonia Autoimmune regulator Gc1-spg 
TranscriptomicsTranscriptome profiling of a backcross between experimental autoimmune encephalomyelitis (EAE)-susceptible DA and EAE-resistant PVG rat strains to identify expression quantitative trait loci.
The aim of the experiment is to characterize the genetics and mechanisms of the inflammatory response after induction of experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis, by studying the genome wide expression in the spleen in late disease. A backcross was created betwe...
ORGANISM(S): Rattus norvegicus 
2013-08-10 | E-MTAB-784 | biostudies-arrayexpress
ProteomicsProtein microarray-based autoantibody screening in 51 APS1 patients and 21 healthy controls
Autoimmune polyendocrine syndrome type 1 (APS1) is a monogenic disorder that features multiple autoimmune disease manifestations. It is caused by mutations in the Autoimmune regulator (AIRE) gene, which promote thymic display of thousands of peripheral tissue antigens in a process critical for estab...
ORGANISM(S): Homo sapiens 
2019-06-27 | E-MTAB-8097 | biostudies-arrayexpress
TranscriptomicsGenetically-driven target tissue over-expression of CD40: A novel mechanism in autoimmune disease
The CD40 gene, an important immune regulatory gene, is also expressed and functional on non-myeloid derived cells, many of which are targets for tissue specific autoimmune diseases, including d thyroid follicular cells in Graves’ disease (GD). Whether target tissue CD40 expression plays a role in au...
ORGANISM(S): Mus musculus 
2012-10-03 | E-GEOD-39081 | biostudies-arrayexpress
TranscriptomicsSex Bias in CNS Autoimmune Disease Mediated by Androgen Control of Autoimmune Regulator
Male gender is protective against multiple sclerosis and other T cell-mediated autoimmune diseases. This protection may be due, in part, to higher androgen levels in males. Androgen binds to the androgen receptor (AR) to regulate gene expression, but how androgen protects against autoimmunity is not...
ORGANISM(S): Mus musculus 
2016-03-09 | E-GEOD-79014 | biostudies-arrayexpress
TranscriptomicsThe effect of the Autoimmune regulator (Aire) gene on mRNA and lncRNA transcriptional profile of mTEC 3.10 cell line
In this study, we used the murine (Mus musculus) medullary thymic epithelial cell line (mTEC 3.10 cell line) co-cultured with fresh thymocytes as a functional assay for mTEC-thymocyte adhesion. Then we analyzed the differential transcriptional profile of this cell line, by means of Agilent oligo mic...
ORGANISM(S): Mus musculus 
2021-12-31 | E-MTAB-6541 | biostudies-arrayexpress
TranscriptomicsscRNA-seq of lymph node of mice where Cip2a locus has been disrupted and wild-type control mice at the peak of Experimental Autoimmune Encephalomyelis
We induced EAE in mice carrying a gene-trap disruption of Cip2a (hereafter referred to as knockout [KO] mice) and wild-type (WT) control C57BL/6J male and female mice, aged 8-12 weeks. We performed scRNA-seq analysis of lymph node cells from five WT and five KO mice at the peak of EAE. The goal was ...
ORGANISM(S): Mus musculus 
2026-09-30 | E-MTAB-17644 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of wild type and aire -/- murine meduallary thymic epithelial cells to study the immunological roles of aire protein in thymus.
Mice used were B6/129 F2's, 3-5 weeks of age, either wild type or with both copies of the autoimmune regulator gene (aire, GenBank #AF079536) disrupted. Thymi from five of these mice of both sexes were removed and pooled. After collagenase/dispase digestion, density gradient fractionation, and fluo...
ORGANISM(S): Mus musculus 
2007-12-15 | E-GEOD-85 | biostudies-arrayexpress
GenomicsHomo sapiens
HEK293 stably expressing Autoimmune regulator protein
PRJNA117587 | ENA
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