Sort   by:  
 Page size 
TranscriptomicsTranscription profiling of mouse hypomorphic for ATG16L1 (implicated in Crohns disease) protein expression reveals a key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells
Susceptibility to Crohn's disease, a complex inflammatory disease involving the small intestine, is controlled by over 30 loci. One Crohn's disease risk allele is in ATG16L1, a gene homologous to the essential yeast autophagy gene ATG16 (ref. 2). It is not known how ATG16L1 or autophagy contributes ...
ORGANISM(S): Mus musculus 
2008-11-15 | E-GEOD-13512 | biostudies-arrayexpress
TranscriptomicsImpact of conditional autophagy knockout on cytotoxic CD8 T cells at day 7 and day 8 after influenza infection
To investigate the role of autophagy on cytotoxic CD8 T cells, we developed a new mouse that expresses an Atg5 gene with loxP sites up- and downstream of the exon 3, Cre-recombinase, T cell receptor specific for the OVA peptide SIINFEKL and the congenic marker Thy1.1. These cells were adoptively tra...
ORGANISM(S): Mus musculus 
2015-04-23 | E-GEOD-49254 | biostudies-arrayexpress
UnknownSpatiotemporal dynamics of autophagy receptors in selective mitophagy.
Not available
S-EPMC5079667 | biostudies-literature
ProteomicsQuantitative proteomics reveals the selectivity of ubiquitin-binding autophagy receptors in the turnover of damaged lysosomes by lysophagy
Removal of damaged organelles via the process of selective autophagy constitutes a major form of cellular quality control. Damaged organelles are recognized by a dedicated surveillance machinery, leading to the assembly of an autophagosome around the damaged organelle, prior to fusion with ...
ORGANISM(S): Homo sapiens (Human) 
2021-09-23 | PXD027476 | Pride
Interaction proteomics Selective autophagy Organelle proteomics Tax1bp1 Lysophagy 
UnknownUbiquitin-coated nanodiamonds bind to autophagy receptors for entry into the selective autophagy pathway.
Not available
S-EPMC5240834 | biostudies-literature
GenomicsMetabolic enzymes moonlight as selective autophagy receptors to protect plants against viral induced cellular damage
Metabolic enzymes moonlight as selective autophagy receptors to protect plants against viral induced cellular damage
PRJNA1103879 | ENA
UnknownMolecular determinants regulating selective binding of autophagy adapters and receptors to ATG8 proteins.
Not available
S-EPMC6499816 | biostudies-literature
ProteomicsABIN1 is an signal-induced autophagy adaptor counteracting LUBAC-mediated linear ubiquitination
ABIN1 KO RAW264.7 cells and stably reconstituted with 3×FLAG-ABIN1 WT or D485N were subjected to mass spectrometric analysis. Three biological replicates were prepared for each condition. Cells were stimulated for 3 hours with 100 ng/ml LPS. ABIN1 was immunoprecipitated with 30 uL anti-FLAG M2 Magne...
ORGANISM(S): Mus Musculus (mouse) 
2022-02-17 | PXD024864 | JPOST Repository
ProteomicsQuantitative mapping of autophagic cargo during nutrient stress reveals YIPF3 - YIPF4 as membrane receptors for Golgiphagy_part2_neurons
During nutrient stress, macroautophagy is employed to degrade cellular macromolecules, thereby providing biosynthetic building blocks while simultaneously remodeling the proteome. While the machinery responsible for initiation of macroautophagy is well characterized, our understanding of the extent ...
ORGANISM(S): Homo sapiens (Human) 
2023-09-13 | PXD043923 | Pride
Human Autophagy Ineurons 
UnknownIdentification and functional analysis of Joka2, a tobacco member of the family of selective autophagy cargo receptors.
Not available
S-EPMC3242614 | biostudies-literature
Sort   by:  
 Page size