Sort   by:  
 Page size 
ProteomicsQuantitative proteomics reveals the selectivity of ubiquitin-binding autophagy receptors in the turnover of damaged lysosomes by lysophagy
Removal of damaged organelles via the process of selective autophagy constitutes a major form of cellular quality control. Damaged organelles are recognized by a dedicated surveillance machinery, leading to the assembly of an autophagosome around the damaged organelle, prior to fusion with ...
ORGANISM(S): Homo sapiens (Human) 
2021-09-23 | PXD027476 | Pride
Interaction proteomics Selective autophagy Organelle proteomics Tax1bp1 Lysophagy 
UnknownThe TMEM192-mKeima probe specifically assays lysophagy and reveals its initial steps.
Not available
S-EPMC10558291 | biostudies-literature
ProteomicsALS-related p97 R155H mutation disrupts lysophagy in iPSC-derived motor neurons
Mutations in the AAA+ ATPase p97 cause multisystem proteinopathy 1 which includes amyotrophic-lateral sclerosis; however, the pathogenic mechanisms that contribute to motor neuron loss remain obscure. Here, we use two induced pluripotent stem cell models differentiated into spinal motor neurons to i...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2025-09-08 | PXD048185 | Pride
Ubxd1 Lysosome Human motor neurons Cb-5083 P97 
UnknownThe ubiquitin-conjugating enzyme UBE2QL1 coordinates lysophagy in response to endolysosomal damage.
Not available
S-EPMC6776906 | biostudies-literature
UnknownLysophagy protects against propagation of α-synuclein aggregation through ruptured lysosomal vesicles.
Not available
S-EPMC10769825 | biostudies-literature
ProteomicsLysosomal damage triggers a p38 MAPK-dependent phosphorylation cascade to promote lysophagy via the small heat shock protein HSP27
Maintenance of lysosomal integrity is essential for cell viability. Upon injury, lysosomes may be targeted for degradation via a form of selective autophagy known as lysophagy, in which autophagosomes engulf damaged lysosomes following the recruitment of adaptor proteins. One of these adaptors, SQST...
ORGANISM(S): Homo sapiens (Human) 
2024-10-22 | PXD051927 | Pride
Sqstm1/p62 Hsp27 Lysophagy. Phosphorylation Phase-separation Condensates 
UnknownPTP4A2 promotes lysophagy by dephosphorylation of VCP/p97 at Tyr805.
Not available
S-EPMC10240998 | biostudies-literature
UnknownA novel SO2 probe inhibits lysophagy induced by Senecavirus A infection by promoting LAMP1 Cys375 sulfenylation.
Not available
S-EPMC12875573 | biostudies-literature
UnknownQuantitative proteomics reveals the selectivity of ubiquitin-binding autophagy receptors in the turnover of damaged lysosomes by lysophagy.
Not available
S-EPMC8523161 | biostudies-literature
UnknownActivation of lysophagy by a TBK1-SCF<sup>FBXO3</sup>-TMEM192-TAX1BP1 axis in response to lysosomal damage.
Not available
S-EPMC11775327 | biostudies-literature
Sort   by:  
 Page size