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ProteomicsEpigenetic inactivation of the autophagy-lysosomal system in the Parkinson’s disease appendix
The gastrointestinal tract may be a site of origin for α-synuclein (α-syn) pathology in idiopathic Parkinson’s disease (PD), and an abundance of aggregated α-syn has recently been demonstrated in both the healthy and PD appendix. However, the molecular changes that enable gut α-syn aggregates to con...
ORGANISM(S): Homo sapiens (Human) 
2021-07-06 | PXD021757 | Pride
Autophagy-lysosomal system Appendix Parkinson's disease 
GenomicsSpinster homolog 1 (spns1)-dependent endocardial autophagy-lysosomal pathway drives valve morphogenesis through the control of Notch1 signaling.
Spinster homolog 1 (spns1)-dependent endocardial autophagy-lysosomal pathway drives valve morphogenesis through the control of Notch1 signaling.
PRJNA1034995 | ENA
UnknownSystems biology of the autophagy-lysosomal pathway.
Not available
S-EPMC3127210 | biostudies-literature
GenomicsSTAT3 enhances sensitivity of glioblastoma to drug-induced autophagy-dependent lysosomal cell death
STAT3 enhances sensitivity of glioblastoma to drug-induced autophagy-dependent lysosomal cell death
PRJNA681849 | ENA
UnknownImpairment of the autophagy-lysosomal pathway in Alzheimer's diseases: Pathogenic mechanisms and therapeutic potential.
Not available
S-EPMC9069408 | biostudies-literature
UnknownCalpain1 inhibition enhances autophagy-lysosomal pathway and ameliorates tubulointerstitial fibrosis in Nephronophthisis.
Not available
S-EPMC12049798 | biostudies-literature
UnknownATM loss disrupts the autophagy-lysosomal pathway.
Not available
S-EPMC8386711 | biostudies-literature
ProteomicsProteomic analysis links truncated tau to lysosome motility, autophagy and endo-lysosomal dysfunction
Tauopathies are characterized by the progressive accumulation of abnormal tau species, which disrupt the autophagy-lysosomal pathway (ALP), a critical system for degrading intracellular macromolecules and aggregated proteins, causing toxicity and cell death. This study investigates the impact of the...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-22 | PXD062128 | Pride
Tauopathies Toxicity Proteomics Mass spectrometry Autosomal 
GenomicsEpigenetic inactivation of the autophagy-lysosomal system in the Parkinson’s disease appendix (2: PD_RNASeq)
Epigenetic inactivation of the autophagy-lysosomal system in the Parkinson’s disease appendix (2: PD_RNASeq)
PRJNA559913 | ENA
GenomicsEpigenetic inactivation of the autophagy-lysosomal system in the Parkinson’s disease appendix (5: OFB)
Epigenetic inactivation of the autophagy-lysosomal system in the Parkinson’s disease appendix (5: OFB)
PRJNA559917 | ENA
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