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ProteomicsNsp1 guides ribosomal start site selection to promote SARS-CoV-2 infection
Host-directed antivirals remain a promising therapeutic approach for many viruses, including SARS-CoV-2 (CoV2), but development of such interventions requires a deeper understanding of virus-host interactions. Here, we use subcellular proteomics to detect CoV2-induced changes in host protein synthes...
ORGANISM(S): Cercopithecus aethiops (Green monkey) (Grivet) 
2024-01-12 | PXD039981 | Pride
Sars-cov-2 Ribosomes Proteostasis Lc-ms/ms Translation 
ProteomicsProteomic analysis of mitochondria from Huntington's Disease patient iPSC-derived neurons
Huntington's disease is caused by an expanded CAG repeat in the huntingtin gene, yeilding a Huntingtin protein with an expanded polyglutamine tract. Patient-derived induced pluripotent stem cells (iPSCs) can help understand disease; however, defining pathological biomarkers in challanging. Here we u...
ORGANISM(S): Homo sapiens (Human) 
2023-02-10 | PXD037526 | Pride
Lc-ms/ms Huntington's disease Mitochondria Neurodegeneration 
ProteomicsProteomic analysis of polysomes isolated from human cells infected with polio, zika or dengue viruses
Viral pathogens are an ongoing threat to public health worldwide. Dissecting their dependence on host biosynthetic pathways could lead to effective antiviral therapies. To define how entero- and flaviviruses redirect host ribosomes to synthesize viral proteins and disable host protein production, we...
ORGANISM(S): Homo sapiens (Human) 
2021-08-17 | PXD024546 | Pride
Lc-ms/ms Ribosomes Viruses Polysomes Human Infection Protein synthesis Proteostasis Protein folding Translation 
ProteomicsPolyglutamine-mediated ribotoxicity disrupts proteostasis and stress responses in Huntington’s Disease
Huntington’s disease (HD) is a neurodegenerative disorder caused by expansion of a CAG trinucleotide repeat in the Huntingtin (HTT) gene, encoding a homopolymeric polyglutamine (polyQ) tract. Although mutant HTT (mHTT) protein is known to aggregate, the links between aggregation and neurotoxicity re...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2024-03-13 | PXD026012 | Pride
Eif5a Ribosome collision Ribosome stalling Huntington's disease Translation Aggregation 
ProteomicsUncovering hidden layers of cell cycle regulation through integrative multi-omic analysis
Studying the complex relationship between transcription, translation and protein degradation is essential to our understanding of biological processes in health and disease. The limited correlations observed between mRNA and protein abundance suggest pervasive regulation of post-transcriptional step...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080771 | MassIVE
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