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TranscriptomicsTesticular lumicrine factors regulate ERK, STAT and NFKB pathways in the initial segment of the rat epididymis to prevent apoptosis
The initial segment of the epididymis is vital for male fertility, therefore, it is important to understand the mechanisms that regulate this important region. Deprival of testicular luminal fluid factors/lumicrine factors from epididymis, a subset of cells within the initial segment undergo apoptos...
ORGANISM(S): Rattus norvegicus 
2011-03-11 | E-GEOD-21806 | biostudies-arrayexpress
ProteomicsImmunoproximity biotinylation reveals the axon initial segment proteome
The axon initial segment (AIS) is a specialized neuronal compartment required for action potential generation and neuronal polarity. However, understanding the mechanisms regulating AIS structure and function has been hindered by an incomplete knowledge of its molecular composition. Here, using immu...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-01-02 | PXD045921 | Pride
Axon initial segment Neuron Proteomics Proximity labeling Scrib Ankyring 
TranscriptomicsRNA-Seq of Drosophila melanogaster Cdk12-null mutants versus control
In a forward genetic screen, we have previously identified a null mutant of Cdk12 that results in alterations in actin dynamics, the axon initial segment and electrophysiology in Drosophila melanogaster. To decipher how Cdk12 may be having these effects, we extracted RNA from pooled Drosophila heads...
ORGANISM(S): Drosophila melanogaster 
2023-01-01 | E-MTAB-12090 | biostudies-arrayexpress
ProteomicsTRIM46 Kinase Assay
Phosphoproteomic analysis of recombinant TRIM46 reacted with CDK5 kinase in vitro.
ORGANISM(S): Mus Musculus (mouse) 
2019-08-29 | PXD014109 | JPOST Repository
ProteomicsKAP3 kinase assay
Phosphoproteomic analysis of recombinant KAP3 reacted with MARK2 kinase in vitro.
ORGANISM(S): Mus Musculus (mouse) 
2019-08-29 | PXD014110 | JPOST Repository
ProteomicsMapping Axon Initial Segment Structure and Function by Iterative Proximity Biotinylation
We constructed AIS-targeted biotin ligase by generating fusion proteins of BirA* with NF186, Ndel1, and Trim46; these chimeras mapped the molecular organization of intracellular membrane, cytosolic, and microtubule compartments of the AIS, respectively
ORGANISM(S): Rattus norvegicus (Rat) 
2020-01-13 | PXD016272 | Pride
Bioid Axon initial segments 
UnknownAlterations of the axon initial segment in multiple sclerosis grey matter.
Not available
S-EPMC9700164 | biostudies-literature
ProteomicsTotal and synaptosomal proteomic analysis
Autism spectrum disorders (ASD) represent neurodevelopmental disorders characterized by social deficits, repetitive behaviors, and various comorbidities, including epilepsy. ANK2, which encodes a neuronal scaffolding protein, is frequently mutated in ASD, but its in vivo functions and disease-relate...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-03-19 | MSV000091510 | MassIVE
GenomicsChanges in the primary cilia in Alzheimer’s disease early development is associated with alterations in the axon initial segment.
Changes in the primary cilia in Alzheimer’s disease early development is associated with alterations in the axon initial segment.
PRJNA1045993 | ENA
UnknownTRIM46 Organizes Microtubule Fasciculation in the Axon Initial Segment.
Not available
S-EPMC6670255 | biostudies-literature
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