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ProteomicshnRNP R promotes O-GlcNAcylation of eIF4G to facilitate axonal protein synthesis
Motoneurons critically depend on precise spatial and temporal control of translation for axon growth and the establishment and maintenance of neuromuscular connections. While defects in local translation have been implicated in the pathogenesis of motoneuron disorders, little is known about mechanis...
ORGANISM(S): Mus musculus (Mouse) 
2024-08-22 | PXD052115 | Pride
Rl2 Axonal translation Ogt Interactome Motoneuron 
GenomicshnRNP R promotes O-GlcNAcylation of eIF4G and facilitates axonal protein synthesis
hnRNP R promotes O-GlcNAcylation of eIF4G and facilitates axonal protein synthesis
PRJNA1011234 | ENA
TranscriptomicsChanges of axonal transcriptomes in response to local Abeta
We report that local application of Abeta(1-42) for 24h triggers changes in the localized transcriptome, while the transcriptome in cell bodies remains largely unchanged. Axonal and somatic mRNA profiles of rat embryonic hippocampal neurons grown in microfluidic chambers were generated by RNA-Seq in...
ORGANISM(S): Rattus norvegicus 
2015-07-14 | E-GEOD-70860 | biostudies-arrayexpress
TranscriptomicsAxonal mRNA in human embryonic stem cell derived neurons
The identification of axonal mRNAs in model organisms has led to the discovery of many axonally translated proteins required for axon guidance and injury response. The extent to which these axonal mRNAs are conserved in humans is unknown. Here we report on the axonal transcriptome of glutamatergic n...
ORGANISM(S): Homo sapiens 
2016-07-29 | E-GEOD-84975 | biostudies-arrayexpress
ProteomicsProNGF elicits retrograde axonal degeneration of basal forebrain neurons via p75NTR and induction of APP
Basal forebrain cholinergic neurons (BFCNs) extend long projections to multiple targets in the brain to regulate cognitive functions, and are compromised in numerous neurodegenerative disorders. Our previous study showed that injury to the target region of these neurons affects their viability in vi...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-05-06 | PXD043846 | Pride
Key words: proneurotrophin Axon degeneration P75ntr Axonal protein synthesis 
ProteomicsAxonal TDP-43 Drives NMJ Disruption through Inhibition of Local Protein Synthesis
Mislocalization of the predominantly nuclear RNA/DNA binding protein, TDP-43, occurs in motor neurons of ~95% of ALS patients, but the contribution of axonal TDP-43 to this fatal neurodegenerative disease is unclear. Here, we find TDP-43 accumulation in the axons of intra-muscular nerves from ALS pa...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-04 | PXD021876 | Pride
Lc-ms/ms Mouse Nmj Als Tdp-43 Neurodegeneration 
TranscriptomicsGlobal transcriptome analysis reveals differences between embryonic and adult dorsal root ganglion axonal mRNAs that are implicated in axonal growth and pain
Local protein synthesis in sensory neuron axons is necessary for axonal regeneration with the efficiency of regeneration decreasing with age. Because the full repertoire of transcripts in embryonic and adult rat sensory axons is unknown we asked how the pool of mRNAs dynamically changes during age...
ORGANISM(S): Rattus norvegicus 
2010-11-23 | E-GEOD-22638 | biostudies-arrayexpress
ProteomicshnRNP R Knock-out affects the axonal and somatic proteome
We grew neurons in microchambers to separate axons and soma in different compartments which could be independently harvested for proteomic analysis. Using this model system, we studied the effect of the knock-out of hnRNP R on the axonal and somatic proteome.
ORGANISM(S): Mus musculus (Mouse) 
2024-08-22 | PXD038368 | Pride
Hnrnp r Axon Proteome 
TranscriptomicshnRNP R promotes O-GlcNAcylation of eIF4G and facilitates axonal protein synthesis
Motoneurons critically depend on precise spatial and temporal control of translation for axon growth and the establishment and maintenance of neuromuscular connections. While defects in local translation have been implicated in the pathogenesis of motoneuron disorders, little is known about the mech...
ORGANISM(S): Mus musculus 
2024-07-24 | GSE242027 | GEO
UnknownTargeting axonal protein synthesis in neuroregeneration and degeneration.
Not available
S-EPMC4322063 | biostudies-literature
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