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TranscriptomicsChanges of axonal transcriptomes in response to local Abeta
We report that local application of Abeta(1-42) for 24h triggers changes in the localized transcriptome, while the transcriptome in cell bodies remains largely unchanged. Axonal and somatic mRNA profiles of rat embryonic hippocampal neurons grown in microfluidic chambers were generated by RNA-Seq in...
ORGANISM(S): Rattus norvegicus 
2015-07-14 | E-GEOD-70860 | biostudies-arrayexpress
ProteomicsA specific matrisome composition drives a regeneration program in peripheral axonal neuropathies
Understanding the multiple mechanisms underlying peripheral nerve regeneration in humans is crucial for developing effective therapies for peripheral axonal neuropathies. Although in vitro and in vivo studies have provided significant insights, human studies exploring the extracellular matrix (ECM) ...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD068740 | Pride
Extracellular matrix remodelling Peripheral nerve regeneration Protein modulation. Axonal neuropathy 
ProteomicsHDAC6 inhibition restores TDP-43 pathology and axonal transport defects in human motor neurons with TARDBP mutations
TDP-43 is the major component of pathological inclusions in most ALS patients and in up to 50% of patients with frontotemporal dementia (FTD). Heterozygous missense mutations in TARDBP, the gene encoding TDP-43, are one of the common causes of familial ALS. In this study, we investigate TDP-43 prote...
ORGANISM(S): Homo sapiens (Human) 
2021-03-15 | PXD023852 | Pride
Induced pluripotent stem cells Axonal transport Tdp-43 Als Tardpb mutation Hdac6 Interactome 
ProteomicsATP-Citrate lyase fuels axonal transport across species
Microtubule (MT)-based transport is an evolutionary conserved processed finely tuned by posttranslational modifications. Among them, tubulin acetylation, which is catalyzed by the α-tubulin N-acetyltransferase 1, Atat1, facilitates the recruitment and processivity of molecular motors along MT tracks...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-16 | PXD021186 | Pride
Citrate Transport 
GenomicsMaintenance of neuronal TDP-43 expression requires axonal lysosome transport
Maintenance of neuronal TDP-43 expression requires axonal lysosome transport
PRJNA1277782 | ENA
UnknownDisruption of axonal transport in neurodegeneration.
Not available
S-EPMC10232001 | biostudies-literature
UnknownMicrotubule Organization Determines Axonal Transport Dynamics.
Not available
S-EPMC5432135 | biostudies-literature
ProteomicsAutophagy lipidation machinery regulates microtubule dynamics to maintain axonal homeostasis
Axon integrity is crucial for neuronal function. To maintain axonal homeostasis neurons have evolved a unique organization of the microtubule (MT) cytoskeleton, which supports axonal morphology and provides tracks for intracellular transport. Although abnormal MT-based trafficking highlights the pat...
ORGANISM(S): Mus musculus (Mouse) 
2020-03-25 | PXD011279 | Pride
Microtubule dynamics Neuron Autophagy Lc3 Axonal homoeostasis 
UnknownEfficient axonal transport of endolysosomes relies on the balanced ratio of microtubule tyrosination and detyrosination.
Not available
S-EPMC11112122 | biostudies-literature
UnknownCryo electron tomography of herpes simplex virus during axonal transport and secondary envelopment in primary neurons.
Not available
S-EPMC3240593 | biostudies-literature
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