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ModelsBaker(2022) - Immunometabolic Model
Novel computational modeling of bioenergetic mechanisms that modulate CD4+ T cell effector and regulatory functions ABSTRACT We built a novel computational model of complex mechanisms at the intersection of immunity and metabolism that regulate CD4+ T cell effector and regulatory functions by usin...
2022-12-02 | MODEL2211070001 | BioModels
MetabolomicsGrowth control of the eukaryote cell: a systems biology study in yeast
Metabolic control analysis is being exploited in a systems biology study of the eukaryotic cell. Using chemostat culture, we have measured the impact of changes in flux (growth rate) on the transcriptome, proteome, endometabolome and exometabolome of the yeast Saccharomyces cerevisiae. Each function...
2012-04-19 | MTBLS8 | MetaboLights
ProteomicsTranscriptomic and proteomic analyses show minimal role for mast cell ST2 in primary Heligmosomoides polygyrus bakeri infection
The IL-33/ST2 pathway is important as part of the type 2 immune response against helminth infections. Mast cells express the highest levels of the IL-33 receptor subunit ST2 of any immune cell, and mast cells can mediate type 2 immune inflammation, however the role of IL-33-driven mast cell respo...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-06 | PXD074451 | Pride
Interleukin-33  il-33  st2  mast cell  heligmosomoides polygyrus bakeri  proteomics  transcriptomics 
UnknownA mathematical framework for the emergence of winners and losers in cell competition.
Not available
S-EPMC7618079 | biostudies-literature
TranscriptomicsTranscription profiling by array of yeast desiccation stress response to dessication in a time series
Response of Saccharomyces cerevisiae strain BY4741 to desiccation
ORGANISM(S): Saccharomyces cerevisiae 
2010-07-16 | E-MEXP-2818 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of the effect of ppGpp, cdiAMP, and cdiGMP on Saccharomyces cerevisiae
Apart from the induction of host immune responses, any influence mediated by the presence of bacterial signalling molecules inside host cells on the latter’s physiology remains poorly defined. To determine the effects of the presence of ppGpp, cdiAMP and cdiGMP in the cytosol on the functioning of...
ORGANISM(S): Saccharomyces cerevisiae 
2017-07-26 | E-MTAB-5128 | biostudies-arrayexpress
UnknownAn automatic adaptive method to combine summary statistics in approximate Bayesian computation.
Not available
S-EPMC7410215 | biostudies-literature
TranscriptomicsTranscription profiling of Xenopus laevis gastrula ventral and dorsal halves at NF stages 10 and 11.5 injected with noggin and dkk-1 plasmid
Studies of the Xenopus organizer have laid the foundation for our understanding of the conserved signaling pathways that pattern vertebrate embryos during gastrulation. Here, we use this wealth of knowledge as leverage in the design and analysis of a genomic visualization of organizer-related gene ...
ORGANISM(S): Xenopus laevis 
2007-10-05 | E-GEOD-3368 | biostudies-arrayexpress
ProteomicsPhosphoproteomics reveals malaria parasite Protein Kinase G as a signalling hub regulating egress and invasion
Our understanding of the key phosphorylation-dependent signalling pathways in the human malaria parasite, Plasmodium falciparum, remains rudimentary. Here we address this issue for the essential cGMP-dependent protein kinase, PfPKG. By employing chemical and genetic tools in combination with quantit...
ORGANISM(S): Plasmodium falciparum 
2017-09-22 | PXD002266 | Pride
Malaria Quantitation Signalling Phosphorylation Parasite Invasion Protein kinase g Tandem mass tags 
TranscriptomicsCryptic Transcription in a set2∆ in Saccharomyces cerevisiae
In cells lacking the histone methyltransferase Set2, initiation of RNA polymerase II transcription occurs inappropriately within the protein-coding regions of genes, rather than being restricted to the proximal promoter. Here, we mapped the transcripts produced in an S. cerevisiae strain lacking Set...
ORGANISM(S): Saccharomyces cerevisiae 
2010-05-17 | E-GEOD-13310 | biostudies-arrayexpress
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