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TranscriptomicsRegulation of filamentation in the human fungal pathogen Candida tropicalis
The yeast-filament transition is essential for the virulence of a variety of fungi that are pathogenic to humans. N-acetylglucosamine (GlcNAc), a ubiquitous molecule in both the environment and host, is one of the most potent inducers of filamentation in Candida albicans and thermally dimorphic fung...
ORGANISM(S): Candida tropicalis MYA-3404 
2016-07-01 | E-GEOD-73340 | biostudies-arrayexpress
ProteomicsCx37 Phosphorylation and cell cycle regulation
Using alanine and aspartate substitutions to mimic dephosphorylated and phosphorylated Cx37, respectively, we showed that induced expression of Cx37 in rat insulinoma cells could arrest cell cycle progression, support cell cycle progression or cause cell death in a phosphosite specific manner. In th...
ORGANISM(S): Mus musculus (Mouse) 
2019-02-13 | PXD012191 | Pride
Gap junction  growth arrest  proliferation  cell death  differential phosphorylation 
ProteomicsComparative exo-proteomic analysis of Trichoderma antagonists induced by oomycete mycelium highlights diverse antagonism strategies
Plant-beneficial fungi from the genus Trichoderma (Hypocreales, Ascomycota) can control oomyceteous plant-pathogenic Pythium myriotylum (Peronosporales, Oomycota) and thus serve as bioeffectors for the eco-friendly products of crop protection. However, the underlying mechanisms of microbe-microbe in...
ORGANISM(S): Trichoderma asperellum CBS 433.97 Trichoderma virens Gv29-8 Hypocrea jecorina (strain QM6a) (Trichoderma reesei) Trichoderma atroviride IMI 206040 Trichoderma parepimyces Trichoderma guizhouense 
2024-07-19 | PXD051895 | Pride
Trichoderma Exo-proteins Hydrolyase Antagonism 
ProteomicsLC/MS Analysis of Myc-Affinity Captured, on-Beads Crosslinked, and on-Beads Digested S. cerevisiae SCC2 subunit of cohesin loading factor
Myc-Affinity Capture and on-Beads Crosslinking For each Saccharomyces cerevisiae strain (C-terminally myc-tagged Scc2 subunit of the cohesin loading factor complex or wild-type BY4741), 2x 3 L YPD medium (add 300 ml 20% Glucose to each 3 L of YPD before using) were separately inoculated in a 5L flas...
ORGANISM(S): Saccharomyces Cerevisiae (ncbitaxon:4932) 
2020-10-20 | MSV000086339 | MassIVE
TranscriptomicsTranscriptomic profiling of clobetasol propionate-induced immunosuppression in challenged zebrafish embryos
The aim of this experiment was to develop an approach for the assessment of immunotoxicity in zebrafish embryos (Danio rerio) using transcriptomic profiling. Clobetasol propionate, a highly potent synthetic corticosteroid, which is known to have immunosuppressive effects on vertebrates including zeb...
ORGANISM(S): Danio rerio 
2022-02-25 | E-MTAB-11092 | biostudies-arrayexpress
ProteomicsProteomic identification of cysteine cathepsin substrates shed from the surface of cancer cells
Extracellular cysteine cathepsins are known to drive cancer progression, but besides degradation of extracellular matrix proteins little is known about their physiological substrates and thus the molecular mechanisms they deploy. One of the major mechanisms used by other extracellular proteases to f...
ORGANISM(S): Homo sapiens (Human) 
2015-06-23 | PXD002192 | Pride
Cancer Substrates Degradomics Shedding Proteases Cathepsins 
ProteomicsQuantitative proteomic comparison between wild type Col and acinus-2 pinin-1 mutant using 15N metabolic labeling
ACINUS and PININ genes regulate transcription and alternative splicing (Bi et al., 2021) and we hypothesize that some proteins should have altered expression in the double mutant. Therefore, MS experiments were designed to identify these altered proteins on a global scale using 15N metabolic labeli...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2022-02-04 | PXD030081 | Pride
Arabidopsis Acinus Quantification 15n metabolic labeling Protein prospector Pinin 
ProteomicsRelative quantification of 15N labeled acinus-2 pinin-1 and 14N labeled Col through Data Dependent Acquisition to obtain peptide information for targeted Parallel Reaction Monitoring experiment
To examine the properties of 14N and 15N labeled peptides using Parallel Reaction Monitoring (PRM) on a high resolution, high accuracy mass spectrometer we first set up this DDA experiment. The purpose of this experiment was to choose peptides that are good candidates for targeted quantification. Th...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2022-06-09 | PXD030098 | Pride
Arabidopsis Quantification Data dependent acquisition 15n metabolic labeling Relative quantification Silac Protein prospector 
MetabolomicsUncovering the Complexity of the Yeast Lipidome by Means of nLC/NSI-MS/MS
Saccharomyces cerevisiae is a eukaryotic model organism widely used for the investigation of fundamental cellular processes and disease mechanisms. Consequently, the lipid landscape of yeast has been extensively investigated and up to this day the lipidome is considered as rather basic. Here, we use...
2021-01-08 | MTBLS2119 | MetaboLights
ProteomicsQuantitative proteomic comparison between wild type Col and sec-5 mutant using 15N metabolic labeling
SECRET AGENT (SEC) is an O-GlcNAc transferase involved in O-GlcNAcylation of many proteins. However, sec-5 null allele mutant phenotype is very subtle. To examine if there are proteins that show altered expression in the sec-5 mutant compared to wild-type Col, we designed MS experiments to identify ...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2022-02-04 | PXD030575 | Pride
Arabidopsis Quantification 15n metabolic labeling Protein prospector Secret agent (sec) 
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