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ProteomicsPhosphodiesterase beta controls cAMP signalling during malaria parasite erythrocyte invasion
Cyclic nucleotide signalling is a major regulator of malaria parasite differentiation. Specific phosphodiesterase (PDE) enzymes are known to control cGMP levels in the parasite, but the mechanisms by with cAMP is regulated remain enigmatic. Here we show that P. falciparum PDEbeta translocates via th...
ORGANISM(S): Homo sapiens (Human) Plasmodium falciparum Mad71/Papua New Guinea 
2019-02-27 | PXD009157 | Pride
Phosphoproteomics Camp Malaria Tmt Pka Orbitrap 
ProteomicsA Protein Kinase G-interacting protein regulates critical calcium signals in malaria parasites (phosphoproteomic)
In malaria parasites, cGMP signalling is mediated by a single cGMP-dependent protein kinase (PKG). One of the major functions of PKG is to control calcium signals essential for the parasite to exit red blood cells or for the transmission of the gametocyte stages to the mosquito. However, how PKG con...
ORGANISM(S): Plasmodium berghei ANKA 
2021-01-25 | PXD020189 | Pride
Gametocytes Lc-msms Plasmodium Phosphoproteomic 
ProteomicsA multipass membrane protein interacts with the cGMP-dependent protein kinase to regulate critical calcium signals in malaria parasites
In malaria parasites, all cGMP-dependent signalling is mediated through a single cGMP-dependent protein kinase (PKG). A major function of PKG is to control calcium signals essential for the parasite to exit red blood cells or for transmission to the mosquito vector. However, how PKG controls these s...
ORGANISM(S): Plasmodium falciparum (isolate 3D7) 
2021-02-10 | PXD020381 | Pride
Transporter Plasmodium falciparum Calcium regulation Plasmodium berghei Phosphoproteomics Cgmp-dependent protein kinase (pkg) 
ProteomicsA Protein Kinase G -interacting protein regulates critical calcium signals in malaria parasites (Co-IP)
In malaria parasites, cGMP signalling is mediated by a single cGMP-dependent protein kinase (PKG) . One of the major functions of PKG is to control calcium signals essential for the parasite to exit red blood cells or for the transmission of the gametocyte stages to the mosquito . However, how PKG c...
ORGANISM(S): Plasmodium berghei ANKA 
2021-01-25 | PXD020210 | Pride
Gametocytes Lc-msms Plasmodium Co-ip 
UnknownCommunity-based health literacy focused intervention for cervical cancer control among Black women living with human immunodeficiency virus: A randomized pilot trial.
Not available
S-EPMC9854322 | biostudies-literature
ProteomicsPlasmodium PKG interacts with ICM1, a multi-pass membrane protein, in both asexual and sexual stages
In malaria parasites, all cGMP-dependent signalling is mediated through a single cGMP-dependent protein kinase (PKG). A major function of PKG is to control calcium signals essential for the parasite to exit red blood cells or for transmission to the mosquito vector. However, how PKG controls these s...
ORGANISM(S): Plasmodium falciparum (isolate 3D7) 
2021-02-10 | PXD020447 | Pride
Lc-msms Malaria Cell signalling Calcium homeostasis Protein kinase g Orbitrap Plasmodium falciparum 
ProteomicsCyclic AMP signalling controls key components of malaria parasite host cell invasion machinery
Cyclic nucleotides are important signalling molecules across evolution, but their roles in malaria parasites are poorly understood. We have investigated the role of cAMP in asexual blood stage development of Plasmodium falciparum through conditional disruption of adenylyl cyclase (ACβ) and its downs...
ORGANISM(S): Homo sapiens (Human) Plasmodium falciparum (isolate 3D7) 
2019-05-14 | PXD012143 | Pride
Host cell invasion Malaria Camp‐dependent protein kinase Adenylyl cyclase β Orbitrap fusion lumos Cyclic nucleotide signalling Ama1 Plasmodium falciparum 
UnknownCircular-SWAT for deep learning based diagnostic classification of Alzheimer's disease: application to metabolome data.
Not available
S-EPMC10579282 | biostudies-literature
UnknownCa2+ signals critical for egress and gametogenesis in malaria parasites depend on a multipass membrane protein that interacts with PKG.
Not available
S-EPMC7990342 | biostudies-literature
UnknownA scalable computational approach to assessing response to name in toddlers with autism.
Not available
S-EPMC8397798 | biostudies-literature
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