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UnknownPlasma Proenkephalin and Poor Long-Term Outcome in Renal Transplant Recipients.

Background

Proenkephalin (pro-ENK), a stable and reliable surrogate marker for unstable enkephalins, was found to be associated with acute kidney injury and chronic renal failure in previous studies. We aimed to investigate whether pro-ENK is linked to chronic kidney injury and poor long-ter...
S-EPMC5540628 | biostudies-literature
UnknownOptimal Screening for Predicting and Preventing the Risk of Heart Failure Among Adults With Diabetes Without Atherosclerotic Cardiovascular Disease: A Pooled Cohort Analysis.

Background

The optimal approach to identify individuals with diabetes who are at a high risk for developing heart failure (HF) to inform implementation of preventive therapies is unknown, especially in those without atherosclerotic cardiovascular disease (ASCVD).

Methods

Adults with d...
S-EPMC11257100 | biostudies-literature
UnknownSerum potassium and adverse outcomes across the range of kidney function: a CKD Prognosis Consortium meta-analysis.

Aims

Both hypo- and hyperkalaemia can have immediate deleterious physiological effects, and less is known about long-term risks. The objective was to determine the risks of all-cause mortality, cardiovascular mortality, and end-stage renal disease associated with potassium levels across the ...
S-EPMC5930249 | biostudies-literature
UnknownPlasma C-Peptide and Risk of Developing Type 2 Diabetes in the General Population.
C-peptide measurement may represent a better index of pancreatic β-cell function compared to insulin. While insulin is mainly cleared by liver, C-peptide is mainly metabolized by kidneys. The aim of our study was to evaluate the association between baseline plasma C-peptide level and the development...
S-EPMC7564789 | biostudies-literature
UnknownAdiposity and risk of decline in glomerular filtration rate: meta-analysis of individual participant data in a global consortium.

Objective

To evaluate the associations between adiposity measures (body mass index, waist circumference, and waist-to-height ratio) with decline in glomerular filtration rate (GFR) and with all cause mortality.

Design

Individual participant data meta-analysis.

Setting

Cohorts f...
S-EPMC6481269 | biostudies-literature
UnknownThe Relation Between Thyroid Function and Anemia: A Pooled Analysis of Individual Participant Data.

Context

Anemia and thyroid dysfunction often co-occur, and both increase with age. Human data on relationships between thyroid disease and anemia are scarce.

Objective

To investigate the cross-sectional and longitudinal associations between clinical thyroid status and anemia.

Desig...

S-EPMC6179176 | biostudies-literature
UnknownApplication of non-HDL cholesterol for population-based cardiovascular risk stratification: results from the Multinational Cardiovascular Risk Consortium.

Background

The relevance of blood lipid concentrations to long-term incidence of cardiovascular disease and the relevance of lipid-lowering therapy for cardiovascular disease outcomes is unclear. We investigated the cardiovascular disease risk associated with the full spectrum of bloodstream...
S-EPMC6913519 | biostudies-literature
UnknownSCORE2 risk prediction algorithms: new models to estimate 10-year risk of cardiovascular disease in Europe.

Aims

The aim of this study was to develop, validate, and illustrate an updated prediction model (SCORE2) to estimate 10-year fatal and non-fatal cardiovascular disease (CVD) risk in individuals without previous CVD or diabetes aged 40-69 years in Europe.

Methods and results

We derived...
S-EPMC8248998 | biostudies-literature
UnknownGenome-wide association analysis identifies ancestry-specific genetic variation associated with acute response to metformin and glipizide in SUGAR-MGH.

Aims/hypothesis

Characterisation of genetic variation that influences the response to glucose-lowering medications is instrumental to precision medicine for treatment of type 2 diabetes. The Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans (SUGAR-MG...
S-EPMC10790310 | biostudies-literature
UnknownSubclinical thyroid dysfunction and depressive symptoms: protocol for a systematic review and individual participant data meta-analysis of prospective cohort studies.

Introduction

Prospective cohort studies on the association between subclinical thyroid dysfunction and depressive symptoms have yielded conflicting findings, possibly because of differences in age, sex, thyroid-stimulating hormone cut-off levels or degree of baseline depressive symptoms. Ana...
S-EPMC6661665 | biostudies-literature
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