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MetabolomicsEmerging mechanisms and promising approaches in pancreatic cancer metabolism.

Pancreatic cancer is an aggressive cancer with a poor prognosis. Metabolic abnormalities are one of the hallmarks of pancreatic cancer, and pancreatic cancer cells can adapt to biosynthesis, energy intake and redox needs through metabolic reprogramming to tolerate nutrient deficiency and hypoxic ...

2025-03-26 | MTBLS12204 | MetaboLights
MetabolomicsIntegrated metabolomic and transcriptomic analysis reveals the neurotoxicity and mechanisms of Shengfu Pian

Background: The mechanisms underlying neurological toxicity are complex. Shengfu Pian (SFP), a traditional Chinese medicine, has drawn increasing attention due to its potential neurotoxic effects.

Methods: To investigate the neurotoxic mechanisms of SFP, we first applied non-targeted serum ...

2025-10-11 | MTBLS13086 | MetaboLights
MetabolomicsMechanisms of hepatic steatosis in chickens: integrated analysis of the host genome, molecular phenomes and gut microbiome

Hepatic steatosis is the initial manifestation of abnormal liver functions and often leads to liver diseases such as non-alcoholic fatty liver disease in humans and fatty liver syndrome in animals. In this study, we conducted a comprehensive analysis of a large chicken population consisting of 70...

2023-07-24 | MTBLS7808 | MetaboLights
MetabolomicsElucidating the molecular mechanisms of Daifu decoction in ulcerative colitis treatment through a multi-omics framework and experimental verification

Background: Ulcerative colitis (UC) is a significant and challenging condition in the digestive system, necessitating the development of effective therapeutic interventions. The Daifu decoction (DFD) is derived from the Lizhong decoction, a classic traditional Chinese Medicine (TCM) formula used ...

2026-03-18 | MTBLS13973 | MetaboLights
MetabolomicsTranscriptomic and Metabolomic Joint Analysis to Explore the Molecular Mechanisms of Different Resistant Poplar Varieties in Response to the Feeding Damage of Anoplophora glabripennis

In China, Asian longhorned beetle (ALB) infestations severely threaten poplar resources, the primary species used for shelterbelt afforestation. Two fast-growing poplar hybrids, Populus alba × (P. alba × P. glandulosa) ...

2026-03-11 | MTBLS14028 | MetaboLights
ProteomicsIntricate coupling between the transactivation and basic-leucine zipper domains governs the CK2-dependent phosphorylation of ATF4
Most transcription factors possess at least one long intrinsically disordered transactivation domain that binds to a variety of co-activators and co-repressors and plays a key role in modulating the transcriptional activity. Despite the crucial importance of these mechanisms, the structural and func...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD029704 | Pride
Atf4 Intrinsically disordered domain Phosphorylation Lc-msms 
UnknownAutophagy and cancer: Basic mechanisms and inhibitor development.
Not available
S-EPMC10323110 | biostudies-literature
UnknownPsychological Contract Violation or Basic Need Frustration? Psychological Mechanisms Behind the Effects of Workplace Bullying.
Not available
S-EPMC8062865 | biostudies-literature
UnknownCircadian rhythms: from basic mechanisms to the intensive care unit.
Not available
S-EPMC3977926 | biostudies-literature
UnknownMolecular basis of normal and pathological puberty: from basic mechanisms to clinical implications.
Not available
S-EPMC10198266 | biostudies-literature
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