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ProteomicsSILAC-based phosphoproteomics reveals new PP2A-Cdc55-regulated processes in budding yeast.
Protein phosphatase 2A (PP2A) is a family of conserved serine/threonine phosphatases involved in several essential aspects of cell growth and proliferation. PP2ACdc55 phosphatase has been extensively related to cell cycle events in budding yeast, however few PP2ACdc55 substrates have been identified...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2018-04-16 | PXD007613 | Pride
Pkc1 Mob1. Mitotic exit network (men) Pp2acdc55 phosphatase Cla4 
ProteomicsDiscovery, characterization and quantification of bioactive peptides contained in Palbio porcine intestinal mucosa hy-drolysate products.
Porcine intestinal mucosa hydrolysates (PIMH) are a by-product of heparin production obtained through a specific enzymatic hydrolysis process which can theoretically generate bioactive pep-tides (BAPs). This study aimed to identify, characterize and quantify BAPs in two Palbio products manufactured ...
ORGANISM(S): Sus scrofa (Pig) 
2025-08-04 | PXD063531 | Pride
Bioactive peptides  antimicrobial peptides  sustainable processing  porcine intestinal mucosa hydrolysate  porcine digestible peptides  bio-compound valorization  animal by-products 
ProteomicsEvaluation of tumor interstitial fluid-extraction methods for proteome analysis: comparison of biopsy elution versus centrifugation
The analysis of Tumor Interstitial Fluid (TIF) composition is a valuable procedure to identify anti-metastatic targets, and different laboratories have set up techniques for TIF isolation and proteomic analyses. However, those methods had never been compared in samples from the same tumor and patien...
ORGANISM(S): Homo sapiens (Human) 
2020-05-06 | PXD016261 | Pride
Cutaneous squamous cell carcinoma Skin cancer Tumor interstitial fluid Spin Proteome Centrifugation Elution 
ProteomicsInhibition of CBP synergizes with the RNA-dependent mechanisms of azacitidine by limiting protein translation
The nucleotide analogue azacitidine (AZA) interferes with RNA and DNA metabolism and is currently the best treatment option for a subset of patients with high-risk myelodysplastic syndromes. However, only half of treated patients respond and almost all patients that initially respond eventually rela...
ORGANISM(S): Homo sapiens (Human) 
2021-09-22 | PXD021738 | Pride
Hypomethylating agents  azacitidine  epigenetic regulation  lysine acetyl tranferase inhibitors  creb binding protein / cbp / p300  shrna screen  protein synthesis Clonal hematopoietic disorders Myelodysplastic syndromes  secondary acute myeloid leukemia 
ProteomicsExploring Diverse Clinical Presentations in COVID-19 through Circulating Extracellular Vesicle Proteomics Analysis
Extracellular vesicles (EVs) released by virus-infected cells are susceptible to incorporate viral peptides. Here, we hypothesized that the molecular characterization of EVs obtained from COVID-19 patients will reveal novel immunogenic viral peptides. Blood from COVID-19 patients with severe (G1), m...
ORGANISM(S): Homo sapiens (Human) Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 
2024-09-25 | PXD041931 | Pride
Proteomics profiling Covid-19 patients Clinical data Ganglioside-capture(siglec-1) Antibody response Extracellular vesicles Size-exclusion chromatography(sec) Tandem mass tag(tmt) Immunocapture(cd9) 
ProteomicsSIRT1 regulates DNA damage signaling through PP4 phosphatase complex
The Sirtuin family of NAD+-dependent enzymes play an important role in the maintenance of genome stability upon stress. Several mammalian Sirtuins have been linked directly or indirectly to the regulation of DNA damage during replication through Homologous recombination (HR). The role of one of them...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2023-06-15 | PXD036905 | Pride
Label free proteomics Pp4 phosphatase complex H2ax Sirt1 Dna damage response 
ProteomicsPlitidepsin is a broad-spectrum antiviral that transiently inhibits viral 1 protein translation and shapes a protective proteostatic cellular response
Plitidepsin is a safe antiviral for COVID-19 patients that impairs SARS-CoV-2 replication by targeting host factors implicated in protein translation. Here we used deep quantitative proteomics coupled to infectious assays and transmission electron microscopy to dissect its antiviral activity. Plitid...
ORGANISM(S): Chlorocebus 
2024-12-19 | PXD041854 | Pride
Plitidepsin Tmt Orbitrap eclipse Sars-cov-2 Covid-19 
ProteomicsCharacterization of secretomes from brain microvascular endothelial cells after ischemia
The human immortalized brain endothelial cell line hCMEC/D3 is considered an in vitro model of the blood-brain-barrier. We aimed to characterize changes in the secretome of hCMEC/D3 subjected to oxygen and glucose deprivation (OGD) by SILAC, in order to identify new proteins involved in ischemia-tri...
ORGANISM(S): Homo sapiens (Human) 
2016-01-21 | PXD002292 | Pride
Hcmec/d3 Endothelial cells Oxygen and glucose deprivation Silac Secretome 
ProteomicsChr16-HPP. Shotgun Analysis improvement. JPR HPP Special issue 2013. MCF7 Cell line.
The Chromosome 16 Consortium is integrated in the Human Proteome Project that aims to develop an entire map of the proteins encoded by the human genome following a gene-centric strategy (C-HPP) to make progress in the understanding of human biology in health and disease (B/D-HPP). To do this study f...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-06-12 | MSV000083962 | MassIVE
ProteomicsChr16-HPP. Shotgun Analysis improvement. JPR HPP Special issue 2013. CCD18 Cell line.
The Chromosome 16 Consortium is integrated in the Human Proteome Project that aims to develop an entire map of the proteins encoded by the human genome following a gene-centric strategy (C-HPP) to make progress in the understanding of human biology in health and disease (B/D-HPP). To do this study f...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-06-12 | MSV000083961 | MassIVE
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