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ProteomicsApplicability of chromatographic co-elution for antibiotic research
Identification of the molecular target is crucial for evaluating novel antibiotics. To support target identification, a label-free method based on chromatographic co-elution (TICC) has been developed previously. In TICC, an alteration in the elution profile of the target-bound drug compared to free ...
ORGANISM(S): Bacillus subtilis subsp. subtilis str. 168 
2020-10-01 | PXD017640 | Pride
Essential proteins Bacillus subtilis Protein complexes Protein-protein interaction 
ProteomicsMultiple solvent elution, a method to counter the effects of Co-Elution and Ion Suppression of peptides in LC-MS analysis.
The abundance of proteins in the cellular proteome ranges from millions of copies to one copy per cell. This wide dynamic range represents a major challenge in proteomic analysis. On average, any human cell type expresses up to approximately 10.000 different protein coding genes that are used to syn...
ORGANISM(S): Homo sapiens (Human) 
2019-06-28 | PXD011908 | Pride
Proteome coverage Co-elution Lc-ms Proteomics Solvents Ion suppression 
ProteomicsEvaluation of tumor interstitial fluid-extraction methods for proteome analysis: comparison of biopsy elution versus centrifugation
The analysis of Tumor Interstitial Fluid (TIF) composition is a valuable procedure to identify anti-metastatic targets, and different laboratories have set up techniques for TIF isolation and proteomic analyses. However, those methods had never been compared in samples from the same tumor and patien...
ORGANISM(S): Homo sapiens (Human) 
2020-05-06 | PXD016261 | Pride
Cutaneous squamous cell carcinoma Skin cancer Tumor interstitial fluid Spin Proteome Centrifugation Elution 
UnknownImproved elution conditions for native co-immunoprecipitation.
Not available
S-EPMC3063181 | biostudies-literature
UnknownDeterminants of protein elution rates from preparative ion-exchange adsorbents.
Not available
S-EPMC4795180 | biostudies-literature
ProteomicsMHC immunopeptidome of JY cells analysed by EThcD at Orbitrap Fusion after mild acid elution
To understand and treat immunology-related diseases, a comprehensive, unbiased characterization of major histocompatibility complex (MHC) peptide ligands is of key importance. Preceding the analysis by mass spectrometry, MHC peptide ligands are typically isolated by MHC immunoaffinity chromatography...
ORGANISM(S): Homo sapiens (Human) 
2020-11-11 | PXD012498 | Pride
Post-translational modification Ethcd Hla ligandome Mild acid elution Cysteinylation Mhc bound peptides 
UnknownDevelopment of an elution device for ViroCap virus filters.
Not available
S-EPMC5648745 | biostudies-literature
ProteomicsMHC immunopeptidome of JY cells analysed by EThcD or HCD at Orbitrap Fusion after mild acid elution
To understand and treat immunology-related diseases, a comprehensive, unbiased characterization of major histocompatibility complex (MHC) peptide ligands is of key importance. Preceding the analysis by mass spectrometry, MHC peptide ligands are typically isolated by MHC immunoaffinity chromatography...
ORGANISM(S): Homo sapiens (Human) 
2020-11-11 | PXD012437 | Pride
Post-translational modification Ethcd Hcd Hla ligandome Mild acid elution Cysteinylation Mhc bound peptides 
UnknownComposite Bone Cements with Enhanced Drug Elution.
Not available
S-EPMC10535863 | biostudies-literature
UnknownA rapid and accurate approach for prediction of interactomes from co-elution data (PrInCE).
Not available
S-EPMC5654062 | biostudies-literature
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