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ProteomicsCharacterizing Peptidase Activity of Barley Endoprotease B in Complex Technical Matrices of the Beer Brewing Process
Barley cysteine endoprotease B (HvEPB) is an important enzyme in plant biology and food production. Pilot-scale fed-batch fermentation with Komagataella phaffii in minimal FM22 medium enabled controlled recombinant HvEPB (r-HvEPB) secretion. Peptidomics across four technological brewing matrices - r...
ORGANISM(S): Komagataella phaffii Hordeum vulgare subsp. vulgare 
2026-07-28 | PXD067323 | Pride
Beer Endoprotease b Epb Proteolysis Peptidases Gluten 
ProteomicsHigher induction temperatures and the native secretion signal peptide promote rye prolamin 75k γ-secalin production in Komagataella phaffii
Background: Gluten proteins from wheat, rye, and barley play a substantial role in human nutrition. At the same time, they can trigger several different immune reactions. This, together with their influence on the quality of grain products and their emerging role as biomaterials, makes them an inter...
ORGANISM(S): Komagataella phaffii Secale cereale 
2025-09-09 | PXD062119 | Pride
Secretion signal peptides Prolamin Komagataella phaffii Erad Secale cereale Upr Gluten 
ProteomicsIdentification of allergenomic signatures in allergic and well-tolerated apple genotypes using LC-MS/MS
The apple fruit (Malus domestica L. Borkh) is one of the most popular fruits worldwide. Beyond their beneficial properties, apples contain proteins that trigger allergic reactions in susceptible consumers. Mal d1 to 4 are allergens present in a variety of different isoforms in apples, with Mal d1 an...
ORGANISM(S): Malus domestica 
2022-05-24 | PXD027753 | Pride
Mal d proteins Proteomics Apple breeding Malus domestica Hypoallergenic Lc-ms/ms 
ProteomicsCharacterization of clumpy adhesion of Escherichia coli to human cells and associated factors influencing antibiotic sensitivity
Escherichia coli intestinal infection pathotypes are characterized by distinct adhesion patterns including the recently described clumpy adhesion phenotype. Here we identify and characterize genetic factors contributing to clumpy adhesion of E. coli strain 4972. In this strain, the transcriptome and...
ORGANISM(S): Escherichia coli 
2024-04-09 | PXD042731 | Pride
Escherichia coli Clumpy adhesion Motility Stress Antibiotic tolerance 
ProteomicsDietary intervention improves health metrics and life expectancy of the genetically obese Titan mouse
Suitable animal models are essential for translational research, especially in the case of complex, multifactorial conditions, such as obesity. The non-inbred mouse (Mus musculus) line Titan, also known as DU6, is one of the world’s longest selection experiments for high body mass and was previously...
ORGANISM(S): Mus musculus (Mouse) 
2022-05-04 | PXD019030 | Pride
Acetylome Shotgun proteomics Titan mouse model Metabolic syndrome 
ProteomicsMigExpress discovers essential cell migration control genes in non-small cell lung cancer
Cell migration is an essential process in health and disease - especially in cancer metastasis. The difficulty to assess migration in high throughput presents a methodological hurdle - hence, only very few screens revealed factors controlling this important process. Here, we introduce MigExpress as...
ORGANISM(S): Homo sapiens (Human) 
2021-04-20 | PXD022146 | Pride
Proteomics Isobaric labeling Tandem mass tags (tmt) Non-small cell lung cancer (nsclc) Transcriptomics Cell migration 
TranscriptomicsHigh-throughput sequencing of matched colorectal normal, tumor and metastasis tissues and proof-of principal bioinformatics modeling of therapeutic consequences of miRNA applications
MiRNAs are discussed as diagnostic and therapeutic molecules. However, effective miRNA drug treatments with miRNAs are so far hampered by the complexity of the miRNA networks. To identify potential miRNA drugs in colorectal cancer, we profiled miRNA and mRNA expression in matching normal, tumor and ...
ORGANISM(S): Homo sapiens 
2013-09-18 | E-GEOD-46622 | biostudies-arrayexpress
UnknownSafety and Efficacy of Combination SARS-CoV-2 Neutralizing Monoclonal Antibodies Amubarvimab Plus Romlusevimab in Nonhospitalized Patients With COVID-19.
Not available
S-EPMC10150320 | biostudies-literature
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