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TranscriptomicsBudding yeast RNA polymerase II CTD phosphorylation and transcription termination factor localization
Whole genome analysis of total RNA pol II, Ser2-, Ser5- and Ser7-phosphorylated RNA pol II, in WT and mutants of the C-terminal domain (CTD) kinases Ctk1 and Kin28, and localization of the termination factors Pcf11, Nrd1 and Rat1. ChIP-chip using ligation-mediated PCR-amplified material hybridized t...
ORGANISM(S): Saccharomyces cerevisiae 
2010-09-15 | E-GEOD-23960 | biostudies-arrayexpress
TranscriptomicsBudding yeast mRNA export and processing factors
This SuperSeries is composed of the following subset Series: GSE30703: Budding yeast mRNA poly( A) site mapping GSE30705: Budding yeast mRNA export and processing factor localization Refer to individual Series
ORGANISM(S): Saccharomyces cerevisiae 
2011-09-24 | E-GEOD-30706 | biostudies-arrayexpress
TranscriptomicsBudding yeast mRNA export and processing factor localization
The yeast mRNA export adaptor Yra1 binds the Pcf11 subunit of cleavage-polyadenylation factor CF1A linking export to 3'-end formation. We found a surprising consequence of this interaction is that Yra1 influences cleavage-polyadenylation. Yra1 competes with the CF1A subunit, Clp1, for binding to Pcf...
ORGANISM(S): Saccharomyces cerevisiae 
2011-09-24 | E-GEOD-30705 | biostudies-arrayexpress
TranscriptomicsBudding yeast mRNA poly(A) site mapping
The yeast mRNA export adaptor Yra1 binds the Pcf11 subunit of cleavage-polyadenylation factor CF1A linking export to 3'-end formation. We found a surprising consequence of this interaction is that Yra1 influences cleavage-polyadenylation. Yra1 competes with the CF1A subunit, Clp1, for binding to Pcf...
ORGANISM(S): Saccharomyces cerevisiae 
2011-09-24 | E-GEOD-30703 | biostudies-arrayexpress
GenomicsEffect of splicing on histone H3 K36 methylation
Histone H3 K36me3 and RNA pol II were localized by ChIP before and after inhibition of splicing by spliceostatin for 12 hr. Total matched reads for the control and SSA treated Hela samples were 11.6 and 8.2 million for anti-H3K36me3 and 6.6 and 5.0 million for anti-pol II. ChIP-seq of histone H3 K36...
ORGANISM(S): Homo sapiens 
2011-09-05 | E-GEOD-30895 | biostudies-arrayexpress
ProteomicsPP1/PNUTS phosphatase binds the restrictor complex and stimulates RNA pol II transcription termination
The restrictor, ZC3H4/WDR82, terminates antisense transcription from bidirectional promoters, but its mechanism is poorly understood. We report that ZC3H4/WDR82 immunoprecipitate with PP1 phosphatase and its nuclear targeting subunit, PNUTS, which binds to WDR82. AlphaFold predicts a complex of PP1/...
ORGANISM(S): Homo sapiens (Human) 
2025-04-06 | PXD061598 | Pride
Pp1 phosphatase Ctd dephosphorylation Zc3h4 Pol ii ctd ser5 phosphorylation Restrictor Wdr82 Transcription termination Transcription elongation 
TranscriptomicsComparative genomic hybridization of Clostridium sporogenes and Clostridium botulinum strains
Clostridium botulinum is a heterogeneous Gram-positive species that comprises four genetically and physiologically distinct groups of bacteria that share the ability to produce botulinum neurotoxin, the most poisonous toxin known to man, and the causative agent of botulism, a severe disease of human...
ORGANISM(S): Clostridium botulinum 
2007-05-23 | E-TABM-264 | biostudies-arrayexpress
UnknownBrief Report: Whole-Exome Sequencing to Identify Rare Variants and Gene Networks That Increase Susceptibility to Scleroderma in African Americans.
Not available
S-EPMC6160338 | biostudies-literature
UnknownHLA and autoantibodies define scleroderma subtypes and risk in African and European Americans and suggest a role for molecular mimicry.
Not available
S-EPMC6955366 | biostudies-literature
UnknownIntegrating de novo and inherited variants in 42,607 autism cases identifies mutations in new moderate-risk genes.
Not available
S-EPMC9470534 | biostudies-literature
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