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ProteomicsCardiac Atrial Compartmentalisation Proteomics: A Modified Density Gradient Method to Analyse Endo-lysosomal Proteins
Evidence that lysosomes are important in cardiac physiology and pathology is now emerging. We describe a label-free method suitable for small cardiac tissue biopsies based on a density-separated fractionation protocol, which allows us to study endo-lysosomal (EL) proteins in guinea pig atria. The t...
ORGANISM(S): Cavia porcellus (Guinea pig) 
2021-09-09 | PXD021277 | Pride
Cardiac Rab proteins Lysosome Guinea-pig Lysosome storage disease Atria 
UnknownProtocol for endolysosomal proteomics in goat atrial tissue using a refined density-gradient approach.
Not available
S-EPMC12741452 | biostudies-literature
UnknownThe relationship between alcohol use and long-term cognitive decline in middle and late life: a longitudinal analysis using UK Biobank.
Not available
S-EPMC6051452 | biostudies-literature
ModelsDupont1991_CaOscillation
This model is according to the paper Signal-induced Ca2+ oscillations: Properties of a model based on Ca2+-induced Ca2+ release. Figure4B in the paper has been reproduced by RoadRunner and MathSBML. Damped Ca2+ oscillations elicited by a transient pulse of InsP3 applied intracellularl...
2024-09-02 | BIOMD0000000117 | BioModels
UnknownA modified density gradient proteomic-based method to analyze endolysosomal proteins in cardiac tissue.
Not available
S-EPMC8384914 | biostudies-literature
ProteomicsSerum autoantibodies to the glutamate receptor delta 2 in paediatric opsoclonus myoclonus ataxia syndrome
Abstract Objective: To identify neuronal surface antibodies in opsoclonus myoclonus ataxia syndrome (OMAS) with contemporary antigen discovery methodology. Methods: OMAS patient serum IgG immunohistochemistry using age-equivalent rat cerebellar tissue was followed by immunoprecipitation, gel electro...
ORGANISM(S): Homo sapiens (Human) Rattus norvegicus (Rat) 
2018-07-30 | PXD009578 | Pride
Autoimmune  cerebellum  encephalitis  glud2  immunotherapy  opsoclonus myoclonus ataxia syndrome (omas)  neuroblastoma  paraneoplastic 
UnknownTumor Imaging Using Radiolabeled Matrix Metalloproteinase-Activated Anthrax Proteins.
Not available
S-EPMC6785798 | biostudies-literature
ProteomicsA TFEB nuclear export signal integrates amino acid supply and glucose availability
How cells coordinate the response to fluctuating carbon and nitrogen availability required to maintain effective homeostasis is a key issue. Amino acid limitation that inactivates mTORC1 promotes de-phosphorylation and nuclear translocation of Transcription Factor EB (TFEB), a key transcriptional re...
ORGANISM(S): Homo sapiens (Human) 
2018-10-18 | PXD009677 | Pride
Glucose lysosome biogenesis running header: tfeb nuclear export Gsk3 Tfeb Nuclear export signal Mtor 
ProteomicsRegulation of CYLD activity and specificity by phosphorylation and ubiquitin-binding CAP-Gly domains
Non-degradative ubiquitin chains and phosphorylation events govern signaling responses by innate immune receptors. The deubiquitinase CYLD in complex with SPATA2 is recruited to receptor signaling complexes by the ubiquitin ligase LUBAC and regulates Met1- and Lys63-linked polyubiquitin and receptor...
ORGANISM(S): Homo sapiens (Human) 
2021-11-02 | PXD026791 | Pride
Cyld phosphorylation and ub-binding 
UnknownAntitumor activity of bis-indole derivatives.
Not available
S-EPMC2754042 | biostudies-literature
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