Sort   by:  
 Page size 
MetabolomicsThe alpha-1A adrenergic receptor agonist A61603 reduces cardiac polyunsaturated fatty acid-Serum raw data
Not available
ORGANISM(S): Mus musculus 
ST000452 | MetabolomicsWorkbench
MetabolomicsThe alpha-1A adrenergic receptor agonist A61603 reduces cardiac polyunsaturated fatty acid-Heart raw data
Not available
ORGANISM(S): Mus musculus 
ST000451 | MetabolomicsWorkbench
ProteomicsAdrenergic Receptor Stimulation Suppresses Metabolism in the Pancreatic β Cell
Glucose-stimulated insulin secretion (GSIS) is suppressed through α-adrenergic receptor stimulation by catecholamines, epinephrine and norepinephrine, in pancreatic β-cells. Previous work has elucidated a bevy of adrenergic regulatory mechanisms beyond traditional Gi-coupled signaling including regu...
ORGANISM(S): Mus musculus (Mouse) 
2019-11-08 | PXD006330 | Pride
Pancreas Mouse Min6 Epinephrine Norepinephrine Insulin Β-cells Catecholamines 
ProteomicsUnbiased quantitative analysis of the cardiac phosphoproteome in response to acute β-adrenergic receptor stimulation in vivo
We utilised Super-SILAC mouse technology to perform an unbiased, quantitative analysis of the cardiac phosphoproteome in mice acutely treated in vivo with either saline or isoprenaline (ISO), a non-selective β-AR agonist. Using a customized mass spectrometry-based workflow (Figure 1), our study iden...
ORGANISM(S): Mus musculus (Mouse) 
2021-12-30 | PXD025569 | Pride
Phosphoproteome  mass spectrometry  β-adrenergic receptor  silac 
ProteomicsBeta-Adrenergic stimulation of breast cancer MDA-MB-231 and bone tropic MDA-MB-231-BoM 1833 cell line secretome
In this study, we aimed to study the effect of Beta-2 Adrenergic Receptor stimulation on secreted proteins in triple negative breast cancer cell lines. We also wanted to compare protein expression in parental or bone tropic metastatic cell lines and how they respond to adrenergic signaling.
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD030371 | Pride
Human Lc-msms Breast cancer Conditioned medium Secreted 
TranscriptomicsMicroarray analysis of a multiple myeloma cell line, MM1S, treated with adenosine A2A and Beta-2 Adrenergic Receptor agonists in combination with dexamethasone
We have used an agnostic approach to identify drug combinations by using combination high throughput screening (cHTS) technology and make the surprising discovery that adenosine A2A and beta-2 adrenergic receptor agonists are highly synergistic, selective and novel agents that enhance glucocorticoid...
ORGANISM(S): Homo sapiens 
2012-03-31 | E-GEOD-30644 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat heart tissue from animals aged 4 and 22 months
Myocardial aging leads to a reduction of beta-adrenergic receptor-induced metabolic and contractile responsiveness. We hypothesize that a change in the patterns of gene expression is important in these age-related events. To test this, hearts were harvested from young and aged male rats (3-4 and 20-...
ORGANISM(S): Rattus norvegicus 
2007-10-10 | E-GEOD-421 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse model of heart failure rescued by beta-adrenergic receptor kinase (betaARKct), vs heart failure and untreated samples
Numerous murine models of heart failure (HF) have been described, many of which develop progressive deterioration of cardiac function. We have recently demonstrated that several of these can be "rescued" or prevented by transgenic cardiac expression of a peptide inhibitor of the beta-adrenergic rece...
ORGANISM(S): Mus musculus 
2007-12-13 | E-GEOD-670 | biostudies-arrayexpress
MetabolomicsClenbuterol exerts antidiabetic activity through metabolic reprogramming of skeletal muscle cells
Activation of the sympathetic nervous system causes pronounced metabolic changes that are mediated by multiple adrenergic receptor subtypes. Systemic treatment with β2-adrenergic receptor agonists results in multiple beneficial metabolic effects, including improved glucose homeostasis. To...
2022-08-26 | MTBLS467 | MetaboLights
ProteomicsDual-omics reveals the different roles of α1 and β-adrenergic receptors in acute sympathetic stress-induced cardiac inflammation
Sympathetic overactivation under strong acute stresses triggers acute cardiovascular events including myocardial infarction (MI), sudden cardiac death, and stress cardiomyopathy. α1-ARs and β-ARs, two dominant subtypes of adrenergic receptors in the heart, play a significant role in the physiologica...
ORGANISM(S): Mus musculus (Mouse) 
2023-01-19 | PXD036011 | Pride
Adrenergic receptor Cardiac inflammation Acute sympathetic stress Dual-omics 
Sort   by:  
 Page size