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Polarized vesicular trafficking directs specific receptors and ion channels to cilia, but the underlying mechanisms are poorly understood. Here we describe a role for DLG1, a core component of the Scribble polarity complex, in regulating ciliary protein trafficking in kidney epithelial cells. Condit...
ORGANISM(S): Homo sapiens (Human) 
2024-05-14 | PXD051912 | Pride
Polarized vesicular trafficking directs specific receptors and ion channels to cilia, but the underlying mechanisms are poorly understood. Here we describe a role for DLG1, a core component of the Scribble polarity complex, in regulating ciliary protein trafficking in kidney epithelial cells. Condit...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD051906 | Pride
The mechanisms underlying recessive Mendelian diseases and the interplay between genotype and phenotype still need to be better understood. It is therefore necessary to characterise the functional effects of missense mutations at the protein level. Here we focus on missense mutations in the intrafla...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD044186 | Pride
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