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ProteomicsSerum and bile proteomics reveal candidates for new noninvasive serum markers of primary sclerosing cholangitis and of risk of disease progression and biliary neoplasia (BILE)
Primary sclerosing cholangitis (PSC) is a chronic liver disease characterized by biliary strictures, cholestasis, and an increased risk of cholangiocarcinoma (CCA). Here, we have used label-free quantitative proteomics to analyze serum and bile samples from non-PSC controls and PSC patients, as well...
ORGANISM(S): Homo sapiens (Human) 
2022-08-03 | PXD026694 | Pride
Human Bile. psc. mass spectrometry 
ProteomicsSerum and bile proteomics reveal candidates for new noninvasive serum markers of primary sclerosing cholangitis and of risk of disease progression and biliary neoplasia.
Primary sclerosing cholangitis (PSC) is a chronic liver disease characterized by biliary strictures, cholestasis, and an increased risk of cholangiocarcinoma (CCA). Here, we have used label-free quantitative proteomics to analyze serum and bile samples from non-PSC controls and PSC patients, as well...
ORGANISM(S): Homo sapiens (Human) 
2022-08-03 | PXD026693 | Pride
Human Bile Mass spectrometry Neoplasia Psc 
TranscriptomicsEffect of pharmacological inhibition of ASBT on bile composition and sclerosing cholangitis in mdr2 knockout mice
We report the effect of a potent pharmacological inhibition of ASBT in mdr2 -/- mice, compared to genetic and treatment controls using RNA-sequencing. Through quantification of mRNA in liver samples, we found significant upregulation of anti-inflammatory and anti-fibrotic gene signatures in mdr2-/-...
ORGANISM(S): Mus musculus 
2016-02-17 | E-GEOD-66231 | biostudies-arrayexpress
ProteomicsBile Proteome Analysis by High Precision Mass Spectrometry to Explore Novel Biomarkers of Primary Sclerosing Cholangitis
Primary sclerosing cholangitis is a chronic inflammatory disease of unknown cause, and the diagnosis is made mainly by imaging findings, with no useful biomarkers. In this study, we aimed to evaluate the usefulness of bile proteome analysis using a high-sensitivity mass spectrometer in comprehensive...
ORGANISM(S): Homo Sapiens (human) 
2023-08-26 | PXD036312 | JPOST Repository
ProteomicsBile Proteome Analysis by High Precision Mass Spectrometry to Explore Novel Biomarkers of Primary Sclerosing Cholangitis
Primary sclerosing cholangitis is a chronic inflammatory disease of unknown cause, and the diagnosis is made mainly by imaging findings, with no useful biomarkers. In this study, we aimed to evaluate the usefulness of bile proteome analysis using a high-sensitivity mass spectrometer in comprehensive...
ORGANISM(S): Homo Sapiens (human) 
2023-08-30 | PXD036391 | JPOST Repository
UnknownBile Acid Profiles in Primary Sclerosing Cholangitis and Their Ability to Predict Hepatic Decompensation.
Not available
S-EPMC8141059 | biostudies-literature
UnknownCytoskeleton Remodeling-Related Proteins Represent a Specific Salivary Signature in PSC Patients.
Not available
S-EPMC11643721 | biostudies-literature
UnknownQuantitative bile and serum proteomics for the screening and differential diagnosis of primary sclerosing cholangitis.
Not available
S-EPMC9409575 | biostudies-literature
UnknownBile and urine peptide marker profiles: access keys to molecular pathways and biological processes in cholangiocarcinoma.
Not available
S-EPMC6941325 | biostudies-literature
UnknownEnvironmental chemicals and endogenous metabolites in bile of USA and Norway patients with primary sclerosing cholangitis.
Not available
S-EPMC9853141 | biostudies-literature
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