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ProteomicsGram negative promiscuous lipoproteins keep surface topology when transplanted from one species to another and can deliver foreign polypeptides to the bacterial surface
In Gram negative bacteria outer membrane-associated lipoproteins caneither face the periplasm orprotrude out of the bacterial surface. The mechanisms involved in lipoprotein transport through the outer membrane are not fully elucidated. A group of lipoproteins reach the surface by using species-spec...
ORGANISM(S): Escherichia coli 
2017-05-11 | PXD005732 | Pride
Escherichia coli Proteomics Omv Mass spectrometry 2d-page 
ProteomicsProtein Extraction methods suitable for muscle tissue proteomic analysis
• Evaluation of two methods for protein extraction from muscle tissues. • Two different extraction methods showed distinct patterns of protein abundance; • Two-dimensional electrophoresis revealed 131 spots with different volumes; • SDS-based buffer (method A) mostly extracted proteins of high MW r...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD053117 | Pride
Mass spectrometry Protein denaturation Muscle tissue Two-dimensional electrophoresis Myopathies. 
ProteomicsMolecular Insights into Central Core Disease: Proteomic Signatures and Potential Therapeutic Biomarkers in RYR1 I4895T Mice
Central Core Disease (CCD) is a congenital myopathy, predominantly caused by mutations in the gene encoding for ryanodine receptor type-1(RYR1), the intracellular Ca2+ release channel embedded in skeletal muscle sarcoplasmic reticulum membrane. One of the most common RYR1 mutations associated to CCD...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-22 | PXD069980 | Pride
Oxidative phosphorylation Myosin fragments Central core disease Glycolysis Pgc1α 
ProteomicsTHE PROTEOME SPECIATION OF AN IMMORTALIZED CYSTIC FIBROSIS CELL LINE: NEW PERSPECTIVES ON THE PATHOPHYSIOLOGY OF THE DISEASE.
Cystic Fibrosis (CF) is a recessively inherited disease caused by mutations in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene. CFTR has a pivotal role in the onset of CF, and several proteins are directly or indirectly involved in its homeostasis. To study these CFTR interactors...
ORGANISM(S): Homo sapiens (Human) 
2022-03-01 | PXD006933 | Pride
Cftr Cystic fibrosis Laminopathies 2d-dige Lc-ms/ms 
ProteomicsDepletion of the RNA binding protein HNRNPD impairs homologous recombination by inhibiting DNA-end resection and inducing R-loop accumulation
DNA double strand break (DSB) repair through homologous recombination (HR) is crucial to maintain genome stability. DSB resection generates a single strand DNA intermediate, which is crucial for the HR process. We used a synthetic DNA structure, mimicking a resection intermediate, as a bait to ident...
ORGANISM(S): Homo sapiens (Human) 
2019-02-26 | PXD012045 | Pride
Rna binding proteins  hnrnpd  dna damage  dna end resection  rna binding proteins  r-loop 
ProteomicsHypothyroidism symptoms in LT4-euthyroid thyroidectomized patients reflect an alteration of the serum proteome
In patients undergoing thyroidectomy one of the goals of post-surgical follow-up is the correct maintenance of thyroid hormone (TH) levels by replacement therapy with levo-thyroxine (LT4). Nevertheless, some patients complain of symptoms of hypothyroidism (memory loss, weight gain, fatigue, depressi...
ORGANISM(S): Homo sapiens (Human) 
2022-04-04 | PXD028378 | Pride
Quality of life Lt4 Hypothyroidism Proteomics Reduced ft3 
ProteomicsBAL proteomic signature of lung adenocarcinoma in IPF patients and its transposition in serum samples for less invasive diagnostic procedures
Idiopathic pulmonary fibrosis (IPF) is a form of chronic and irreversible fibrosing interstitial pneumonia of unknown aetiology, with an average survival time of 3-5 years after diagnosis. Emerging evidence suggests that IPF increases the risk of lung carcinogenesis. Both diseases show similarities ...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD037720 | Pride
Ipf Lung cancer Proteomics Apolipoprotein e Nampt Calgranulin b Biomarkers Bal Profilin 1 Apolipoprotein a1 
ProteomicsProteome characterization of BALF extracellular vesicles in Idiopathic Pulmonary Fibrosis: unveiling undercover molecular pathways.
In the longtime challenge of identifying specific, easily-detectable and reliable biomarkers of interstitial lung diseases (ILDs), alternative biofluids, such as bronchoalveolar lavage fluid (BALF), have been extensively studied. In particular, BALF proteomics is gaining momentum and providing inter...
ORGANISM(S): Homo sapiens (Human) 
2021-08-06 | PXD025590 | Pride
Balf  extracellular vesicles  ipf  fibrosis  shotgun  proteomics 
ProteomicsSerum proteomic profile of asthmatic patients after 6 months of Benralizumab and Mepolizumab treatment
Severe eosinophilic asthma is characterized by chronic airway inflammation, oxidative stress and elevated proinflammatory cytokines, especially IL-5. Mepolizumab and benralizumab are both humanized IgG antibodies directed against IL-5 signaling, directly acting on eosinophils count. Together with th...
ORGANISM(S): Homo sapiens (Human) 
2022-04-01 | PXD029793 | Pride
Apoc Severe eosinophilic asthma. Mepolizumab  benralizumab  ceruloplasmin  plasminogen  apoa1 
ProteomicsFIRST ATTEMPT TO COUPLE PROTEOMIC WITH AhR REPORTER GENE BIOASSAY IN SOIL POLLUTION MONITORING AND ASSESSMENT
A topsoil sample obtained from a highly industrialized area was tested on CALUX® cell line and exposed cells processed with proteomic and bioinformatics analyses. GC-MS/MS analysis of topsoil extracts was also performed to confirm PCDD, PCDF and dl-PCBs presence. CALUX® and GC-MS/MS data confirmed ...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-02-17 | PXD027074 | Pride
Dr-calux  proteomics  polychlorinated dibenzo-p-dioxins  polychlorinated dibenzofurans  dioxin-like polychlorinated biphenyls. 
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