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ProteomicsDietary restriction transforms the mammalian protein sulfhydrome in a tissue-specific and cystathionine γ-lyase-dependent manner
Hydrogen sulfide (H2S) is a cytoprotective redox-active metabolite that signals through protein persulfidation (R-SSnH). Despite the known importance of persulfidation on relatively few identified proteins, tissue-specific sulfhydrome profiles and their associated functions are not well characterize...
ORGANISM(S): Mus musculus (Mouse) 
2021-01-25 | PXD022956 | Pride
Persulfidation Longevity Dietary restriction (dr) Redox metabolism Cth) Cysteine Every other day (eod) fasting Biotin thiol assay (bta) Cse Cystathionine γ-lyase (cgl Sulfhydrome Hydrogen sulfide (h2s) Sulfhydration 
ProteomicsPeripubertal Bisphenol A Exposure Imparts Detrimental Acute and Aging-Related Changes in Body Composition, Cognition, and H2S Production and Signaling
Peripubertal endocrine disruption has immediate and lifelong consequences on health, cognition, and lifespan. Disruption comes from dietary, environmental, and pharmaceutical sources. The plasticizer Bisphenol A (BPA) is one such endocrine disrupting chemical (EDC). However, it’s unclear if peripube...
ORGANISM(S): Mus musculus (Mouse) 
2021-05-25 | PXD025746 | Pride
Endocrine disruption Bisphenol a (bpa) Cognition H2s Peripubertal Persulfidation Aging 
ProteomicsDietary restriction transforms the mammalian protein sulfhydrome in a tissue-specific and cystathionine γ-lyase-dependent manner
Hydrogen sulfide (H2S) is a cytoprotective redox-active metabolite that signals through protein persulfidation (R-SSnH). Despite the known importance of persulfidation on relatively few identified proteins, tissue-specific sulfhydrome profiles and their associated functions are not well characterize...
ORGANISM(S): Mus musculus (Mouse) 
2021-01-25 | PXD022954 | Pride
Persulfidation Longevity Dietary restriction (dr) Redox metabolism Cth) Cysteine Every other day (eod) fasting Biotin thiol assay (bta) Cse Cystathionine γ-lyase (cgl Sulfhydrome Hydrogen sulfide (h2s) Sulfhydration 
ProteomicsDietary restriction transforms the mammalian protein sulfhydrome in a tissue-specific and cystathionine γ-lyase-dependent manner
Hydrogen sulfide (H2S) is a cytoprotective redox-active metabolite that signals through protein persulfidation (R-SSnH). Despite the known importance of persulfidation on relatively few identified proteins, tissue-specific sulfhydrome profiles and their associated functions are not well characterize...
ORGANISM(S): Mus musculus (Mouse) 
2021-01-25 | PXD022888 | Pride
Persulfidation Longevity Dietary restriction (dr) Redox metabolism Cth) Cysteine Every other day (eod) fasting Biotin thiol assay (bta) Cse Cystathionine γ-lyase (cgl Sulfhydrome Hydrogen sulfide (h2s) Sulfhydration 
ProteomicsSEVERE CONSEQUENCES OF A HIGH-LIPID DIET INCLUDE HYDROGEN SULFIDE DYSFUNCTION AND DISEASE AGGRESSION IN GLIOBLASTOMA
Glioblastoma (GBM) remains among the deadliest of human malignancies, and the emergence of the cancer stem cell (CSC) phenotype represents a major challenge to durable treatment response. Because the environmental and lifestyle factors that impact CSC populations are not clear, we sought to underst...
ORGANISM(S): Mus musculus (Mouse) 
2021-05-25 | PXD025902 | Pride
Metabolism Glioblastoma Diet Cancer stem cells Hydrogen sulfide 
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