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ProteomicsNATURAL PRODUCT DERIVED IANTHELLIFORMISAMINES INHIBIT PROTEIN TRANSLATION AND BLOCK BACTERIAL FLAGELLUM ASSEMBLY
Natural products have been a great source for novel drugs especially antibiotics. Given the current antibiotic crisis, revisiting poorly characterized antibacterial natural products may reveal novel modes of action (MoA) as inspiration for drug development. Here, we selected the natural product clas...
ORGANISM(S): Escherichia coli 
2026-05-25 | PXD070366 | Pride
Abpp E. coli k12 Orbitrap eclipse tribrid instrument 
TranscriptomicsTranscriptome analysis of the archaeon Thermoplasma acidophilum cultured under aerobic and anaerobic conditions
Investigation of whole genome gene expression level changes in Thermoplasma acidophilum cultured under aerobic and anaerobic conditions. The analysis are further described in Na Sun, Cuiping Pan, Stephan Nickell, Matthias Mann, Wolfgang Baumeister, and István Nagy, Quantitative proteome and transcri...
ORGANISM(S): Thermoplasma acidophilum DSM 1728 
2011-09-26 | E-GEOD-21956 | biostudies-arrayexpress
TranscriptomicsEngineering topology and kinetics of sucrose metabolism in Saccharomyces cerevisiae for improved ethanol yield
Sucrose is a major carbon source for industrial bioethanol production by Saccharomyces cerevisiae. In yeasts, two modes of sucrose metabolism occur: (i) extracellular hydrolysis by invertase, followed by uptake and metabolism of glucose and fructose, and (ii) uptake via sucrose-H+ symport followed b...
ORGANISM(S): Saccharomyces cerevisiae 
2011-09-05 | E-GEOD-30535 | biostudies-arrayexpress
TranscriptomicsHGPalmer-PDX-NVP-TNKS656
Strong activation of the oncogenic Wnt/beta-catenin pathway is a main mechanism of resistance to FOXO3a-induced apoptosis promoted by PI3K and AKT inhibitors in colorectal cancer (CRC). Reducing Wnt/beta-catenin activity would sensitize colorectal tumors to these inhibitors. However, no Wnt/beta-cat...
ORGANISM(S): Homo sapiens 
2015-08-10 | E-MTAB-2446 | biostudies-arrayexpress
TranscriptomicsAdrenocortical Carcinoma Gene Expression Profiling [Affymetrix]
Background: Adrenocortical carcinoma (ACC) is associated with poor survival rates. The objective of the study was to analyze ACC gene expression profiling data prognostic biomarkers and novel therapeutic targets. Methods: 44 ACC and 4 normal adrenal glands were profiled on Affymetrix U133 Plus 2 ex...
ORGANISM(S): Homo sapiens 
2013-11-21 | E-GEOD-19750 | biostudies-arrayexpress
UnknownIn vitro Analysis of O-Antigen-Specific Bacteriophage P22 Inactivation by Salmonella Outer Membrane Vesicles.
Not available
S-EPMC7541932 | biostudies-literature
TranscriptomicsIdentification of beta-cetenin/TCF4 target genes in LS174T colorectal cancer cells using gene expression arrays
Aberrant activation of WNT signaling and loss of BMP signals represent the two main alterations leading to the initiation of colorectal cancer (CRC). Here we screen for genes required for maintaining the tumor stem cell phenotype and identify the zinc-finger transcription factor GATA6 as key regulat...
ORGANISM(S): Homo sapiens 
2014-05-20 | E-GEOD-56896 | biostudies-arrayexpress
UnknownIsoforms of the Papillomavirus Major Capsid Protein Differ in Their Ability to Block Viral Spread and Tumor Formation.
Not available
S-EPMC8964102 | biostudies-literature
ProteomicsPlasma proteomics of BACE1, 2, and double KO mice
The beta-secretase BACE1 is a central drug target for Alzheimer’s disease. Clinically tested, BACE1-directed inhibitors also block the homologous protease BACE2. Yet, little is known about physiological BACE2 substrates and functions in vivo. Here, we performed glycoprotein enrichment and subsequent...
ORGANISM(S): Mus musculus (Mouse) 
2024-06-27 | PXD041577 | Pride
Bace2 Glycocapture Beta secretase Plasma 
ProteomicsPlasma proteomics of BACE2 KO mice
The beta-secretase BACE1 is a central drug target for Alzheimer’s disease. Clinically tested, BACE1-directed inhibitors also block the homologous protease BACE2. Yet, little is known about physiological BACE2 substrates and functions in vivo. Here, we performed discovery proteomics to identify subst...
ORGANISM(S): Mus musculus (Mouse) 
2024-06-27 | PXD041579 | Pride
Bace2 Beta secretase Plasma Mouse 
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