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TranscriptomicsStaphylococcus epidermidis biofilms transcriptome alterations upon incubation with whole human blood
The ability of S. epidermidis to withstand the high bactericidal activity of the hostM-bM-^@M-^Ys blood is crucial for its systemic dissemination. Hence, in order to identify genes and pathways involved in the bacteriumM-bM-^@M-^Ys survival in human blood, we have characterized the transcriptome of ...
ORGANISM(S): Staphylococcus epidermidis 
2014-08-29 | E-GEOD-52111 | biostudies-arrayexpress
Genomicsblood metagenome
Sequencing of bacterial pathogens from blood cultures
PRJNA890573 | ENA
MetabolomicsBiochemical Profiling of the Brain and Blood Metabolome in a Mouse Model of Prodromal Parkinson’s Disease Reveals Distinct Metabolic Profiles (MS assays)
Parkinson’s disease is the second most common neurodegenerative disease. In the vast majority of cases the origin is not genetic and the cause is not well understood, although progressive accumulation of α-synuclein aggregates appears central to the pathogenesis. Currently, treatments that slow dise...
2019-02-07 | MTBLS674 | MetaboLights
TranscriptomicsInduction of adaptive changes in the Streptococcus agalactiae transcriptome by human blood
In the present investigation, we conducted a bacterial transcriptome dynamics analysis during GBS incubation with human blood. We observed a large modification in the expression of genes involved in transcriptional regulation and in the metabolism of carbohydrates, purins/pyrimidins and inorganic io...
ORGANISM(S): Streptococcus agalactiae 
2008-10-31 | E-GEOD-11705 | biostudies-arrayexpress
ProteomicsRapid detection of beta-lactam, aminoglycoside and fluoroquinolone resistance mechanisms in blood cultures positive for E. coli or K. pneumoniae using targeted LC-MS/MS
New and rapid antimicrobial susceptibility/resistance testing methods are required for bacteria from positive blood cultures. In the current study we developed and evaluated a targeted LC-MS/MS assay for the detection of beta-lactam, aminoglycoside and fluoroquinolone resistance mechanisms in blood ...
ORGANISM(S): Klebsiella pneumoniae JH1 Klebsiella variicola At-22 Acinetobacter sp. PM-14 Escherichia coli 
2022-07-01 | PXD025365 | Pride
Blood cultures Gyra E. coli Liquid chromatography-mass spectrometry Sepsis Qnr proteins Parallel reaction monitoring Aminoglycoside modifying enzymes K. pneumoniae 16s ribosomal rna methyltransferases Beta-lactamases Antimicrobial resistance 
MetabolomicsBiochemical Profiling of the Brain and Blood Metabolome in a Mouse Model of Prodromal Parkinson’s Disease Reveals Distinct Metabolic Profiles (NMR assay)
Parkinson’s disease is the second most common neurodegenerative disease. In the vast majority of cases the origin is not genetic and the cause is not well understood, although progressive accumulation of α-synuclein aggregates appears central to the pathogenesis. Currently, treatments that slow dise...
2019-02-07 | MTBLS640 | MetaboLights
TranscriptomicsCulture induced changes in Blood-Brain Barrier transcriptome: implications for amino acid transporters in vivo
Tight homeostatic control of brain amino acids (AA) depends on transport via solute family carrier proteins expressed by the Blood-Brain Barrier (BBB) microvascular endothelial cells (BMEC). To characterize the mouse BMEC transcriptome and probe culture-induced changes microarray analyses of PECAM-1...
ORGANISM(S): Mus musculus 
2010-05-18 | E-GEOD-14375 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human differentiating cord blood derived megakaryocytes
Ex vivo differentiation of megakaryocytes (Mk) was carried out using human cord blood (CB) CD34+ cells under the stimulation of recombinant human interleukin-3, stem cell factor, and thrombopoietin for 7 days, followed by thrombopoietin treatment alone for further 3 days. Total cellular RNA was extr...
ORGANISM(S): Homo sapiens 
2009-03-25 | E-MEXP-1546 | biostudies-arrayexpress
TranscriptomicsComparison of M. tuberculosis and M. bovis BCG in diluted whole blood cultures
Despite wide scale vaccination with Mycobacterium bovis BCG, the prevalence of tuberculosis remains high, reflecting the global variable efficacy of this vaccine against adult pulmonary TB. Characterisation of different immune responses to M. tuberculosis and M. bovis BCG would increase understandi...
ORGANISM(S): Homo sapiens 
2015-09-10 | E-GEOD-45386 | biostudies-arrayexpress
TranscriptomicsDifferential Streptococcus agalactiae gene expression in human blood according to the blood donors
In the present investigation, we conducted a bacterial transcriptome dynamics analysis during GBS incubation with human blood. We observed large modification in the expression of numerous genes, but GBS transcriptome was different with the blood of one donor. More genes were up-regulated and less do...
ORGANISM(S): Streptococcus agalactiae 
2009-06-01 | E-GEOD-12201 | biostudies-arrayexpress
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