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ProteomicsThe Bloom Syndrome Complex Senses RPA-Coated Single-Stranded DNA to Restart Stalled Replication Forks
The Bloom syndrome helicase BLM interacts with topoisomerase IIIa (TOP3A), RMI1 and RMI2 to form the BTR complex, which dissolves double Holliday junctions to produce non-crossover products during homologous recombination (HR). BLM also promotes DNA-end resection and stalled replication fork restart...
ORGANISM(S): Homo sapiens (Human) 
2021-01-05 | PXD018322 | Pride
Bloom syndrome Dna damage response Blm Rpa Homologous recombination Replication stress 
TranscriptomicsBloom syndrome protein modulates protein-coding gene and miRNA expression as a function of G4 DNA content
Bloom syndrome is a rare autosomal recessive genetic instability and cancer predisposition syndrome caused by loss of function mutations in the BLM RECQ helicase gene. To ask if some of the distinctive pathological features of Bloom syndrome might reflect altered gene expression, we analyzed global ...
ORGANISM(S): Homo sapiens 
2014-06-12 | E-GEOD-54502 | biostudies-arrayexpress
ProteomicsBLM complex composition in unperturbed cells
The Bloom syndrome DNA helicase BLM contributes to chromosome stability through its roles in double-strand break repair by homologous recombination and DNA replication fork restart during the replication stress response. Loss of BLM activity leads to Bloom syndrome, which is characterized by extraor...
ORGANISM(S): Homo sapiens (Human) 
2022-02-15 | PXD018823 | Pride
Gm00637 Q exactive plus Human 
ProteomicsThe Bloom’s syndrome helicase BLM functions as a homodimer within the Bloom’s complex
Homologous recombination (HR) is an essential and highly regulated cellular process. Unintended HR in somatic cells is potentially deleterious; it can result in translocations and/or somatic cell loss of heterozygosity. This is suppressed by the BLM protein in combination with topoisomerase III, RM...
ORGANISM(S): Homo sapiens (Human) 
2022-01-17 | PXD011078 | Pride
Blm Crosslinking ms Structural proteomics Bloom’s syndrome 
UnknownMechanism of Bloom syndrome complex assembly required for double Holliday junction dissolution and genome stability.
Not available
S-EPMC8832983 | biostudies-literature
TranscriptomicsMetatranscriptomes of phytoplankton blooms from an ocean acidification mesocosm experiment
Sequencing the metatranscriptome can provide information about the response of organisms to varying environmental conditions. We present a methodology for obtaining random whole-community mRNA from a complex microbial assemblage using Pyrosequencing. The metatranscriptome had, with minimum contamina...
ORGANISM(S): marine metagenome 
2008-02-08 | E-GEOD-10119 | biostudies-arrayexpress
ProteomicsMechanistic basis for the spatiotemporal assembly of the Bloom Syndrome complex on ultrafine DNA bridges
The BTRR (BLM/TOP3A/RMI1/RMI2) complex resolves DNA replication and recombination intermediates, as well as mitotic DNA intertwinements, yet how its diverse activities are regulated remains unclear. Here, we identify key determinants of stable assembly of the BTRR complex on ultrafine DNA bridges (U...
ORGANISM(S): Homo sapiens (Human) 
2026-07-30 | PXD081930 | Pride
Bloom syndrome complex Ultrafine dna bridges 
UnknownKNO1-mediated autophagic degradation of the Bloom syndrome complex component RMI1 promotes homologous recombination.
Not available
S-EPMC10183828 | biostudies-literature
UnknownThe Bloom syndrome complex senses RPA-coated single-stranded DNA to restart stalled replication forks.
Not available
S-EPMC7838300 | biostudies-literature
UnknownStructure and cellular roles of the RMI core complex from the bloom syndrome dissolvasome.
Not available
S-EPMC2937010 | biostudies-literature
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